pactamycin

antibioticmech:aro-8218cfc5a1 ·ANTIBACTERIAL ·MINTED SEEDED

Antibiotic produced by Streptomyces pactum, considered a universal translation inhibitor. — PMID:9398510

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

pactamycin-like antibioticARO:3007158

Strictly broader compounds or drug classes this molecule belongs to.

ARO:3007158 ARO:3007158

Chemical structure

Computed structure properties
Molecular formula	C28H38N4O8
Charge	0
Average mass	558.6 Da
Monoisotopic mass	558.26896418 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	WVIUOSJLUCTGFK-JUJPXXQGSA-N

SMILES

CC1=C(C(=CC=C1)O)C(=O)OC[C@]2([C@H]([C@@H]([C@]([C@@]2(C)O)([C@H](C)O)NC(=O)N(C)C)N)NC3=CC=CC(=C3)C(=O)C)O

InChI

InChI=1S/C28H38N4O8/c1-15-9-7-12-20(35)21(15)24(36)40-14-27(39)23(30-19-11-8-10-18(13-19)16(2)33)22(29)28(17(3)34,26(27,4)38)31-25(37)32(5)6/h7-13,17,22-23,30,34-35,38-39H,14,29H2,1-6H3,(H,31,37)/t17-,22-,23-,26-,27+,28-/m0/s1

Cross-references

Equivalent identifiers for this same structure in other resources.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3003975`	pactamycin	`antibioticmech:aro-8218cfc5a1`	2026-08-30

Resistance mechanisms

1 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 1

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Halobacterium salinarum 16S rRNA mutation conferring resistance to pactamycin	ARO:3003977	not organism-specific	—	ARO:3003977 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003975 (pactamycin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.