pactamycin

antibioticmech:aro-8218cfc5a1 ·ANTIBACTERIAL ·MINTED SEEDED

Antibiotic produced by Streptomyces pactum, considered a universal translation inhibitor. — PMID:9398510

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

pactamycin-like antibioticARO:3007158

Strictly broader compounds or drug classes this molecule belongs to.

pactamycin-like antibiotic ARO:3007158

Chemical structure

Computed structure properties
Molecular formula	C28H38N4O8
Charge	0
Average mass	558.6 Da
Monoisotopic mass	558.26896418 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	WVIUOSJLUCTGFK-JUJPXXQGSA-N

SMILES

CC1=C(C(=CC=C1)O)C(=O)OC[C@]2([C@H]([C@@H]([C@]([C@@]2(C)O)([C@H](C)O)NC(=O)N(C)C)N)NC3=CC=CC(=C3)C(=O)C)O

InChI

InChI=1S/C28H38N4O8/c1-15-9-7-12-20(35)21(15)24(36)40-14-27(39)23(30-19-11-8-10-18(13-19)16(2)33)22(29)28(17(3)34,26(27,4)38)31-25(37)32(5)6/h7-13,17,22-23,30,34-35,38-39H,14,29H2,1-6H3,(H,31,37)/t17-,22-,23-,26-,27+,28-/m0/s1

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3003975`	pactamycin	`antibioticmech:aro-8218cfc5a1`	2026-08-30

Resistance mechanisms

1 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 1

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Halobacterium salinarum 16S rRNA mutation conferring resistance to pactamycin	ARO:3003977	not organism-specific	—	ARO:3003977 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003975 (pactamycin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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