AntibioticMech

paromomycin

CHEBI:7934 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-α-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

aminoglycoside antibioticARO:0000016

Strictly broader compounds or drug classes this molecule belongs to.

Chemical structure

Computed structure properties
Molecular formulaC23H45N5O14
Charge0
Average mass615.634 Da
Monoisotopic mass615.2963 Da
SourceChEBI
InChIKeyUOZODPSAJZTQNH-LSWIJEOBSA-N

SMILES

NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O

InChI

InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

Also called

Cross-references

Equivalent identifiers for this same structure in other resources.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
SourceNative IDLabelMinted CURIEVersion
ARO ARO:3000657 paromomycin antibioticmech:aro-7aea35b214 2026-08-30
CHEBI CHEBI:7934 paromomycin antibioticmech:chebi-c0019b6d96 2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000755

CARD/ARO database assertion; target organism, strain, and assay are not specified. 16S rRNA is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

Resistance mechanisms

16 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_INACTIVATION 15
ANTIBIOTIC_INACTIVATION
DeterminantARO IDOrganismGene familiesEvidence
AAC(3)-IIIa ARO:3002536 not organism-specific —
  • ARO:3002536 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
AAC(3)-IIIb ARO:3002537 not organism-specific —
  • ARO:3002537 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
AAC(3)-VIIa ARO:3002541 not organism-specific —
  • ARO:3002541 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-IIIa ARO:3002647 not organism-specific —
  • ARO:3002647 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-IIa ARO:3002644 not organism-specific —
  • ARO:3002644 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-IIb ARO:3002645 not organism-specific —
  • ARO:3002645 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-IIc ARO:3002646 not organism-specific —
  • ARO:3002646 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-IVa ARO:3002648 not organism-specific —
  • ARO:3002648 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-Ia ARO:3002641 not organism-specific —
  • ARO:3002641 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-Ib ARO:3002642 not organism-specific —
  • ARO:3002642 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-VIa ARO:3002652 not organism-specific —
  • ARO:3002652 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-VIb ARO:3002653 not organism-specific —
  • ARO:3002653 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-Va ARO:3002649 not organism-specific —
  • ARO:3002649 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-Vb ARO:3002650 not organism-specific —
  • ARO:3002650 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
APH(3')-Vc ARO:3002651 not organism-specific —
  • ARO:3002651 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)
ANTIBIOTIC_TARGET_ALTERATION 1
ANTIBIOTIC_TARGET_ALTERATION
DeterminantARO IDOrganismGene familiesEvidence
Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to paromomycin ARO:3003403 not organism-specific —
  • ARO:3003403 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000657 (paromomycin); database assertion, not a primary citation.)

Curation history

  1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Seeded from data/raw/ inventories (ARO, CHEBI)

  2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.