perchlozone

antibioticmech:aro-1c565a1a6c ·ANTIBACTERIAL ·MINTED SEEDED

Perchlozone is a novel thiosemicarbazone used for the treatment of multidrug-resistant tuberculosis. It is similar to thiacetazone with only a different side chain attached to the thiosemicarbazone moiety. Perchlozone is a prodrug that is activated by ethA and inhibits the HadABC complex. — PMID:25704063

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

thiosemicarbazone antibioticARO:3007161

Strictly broader compounds or drug classes this molecule belongs to.

thiosemicarbazone antibiotic ARO:3007161

Chemical structure

Computed structure properties
Molecular formula	C7H8N4S
Charge	0
Average mass	180.23 Da
Monoisotopic mass	180.04696745 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	QTSJJDIDTYFLFC-YHYXMXQVSA-N

SMILES

C1=CN=CC=C1/C=N\NC(=S)N

InChI

InChI=1S/C7H8N4S/c8-7(12)11-10-5-6-1-3-9-4-2-6/h1-5H,(H3,8,11,12)/b10-5-

Also called

4-thioureido-iminomethylpyridinium perchlorate (EXACT_SYNONYM)— aro

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

perchlozoneARO:3005175
pubchem.compound:5374694

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3005175`	perchlozone	`antibioticmech:aro-1c565a1a6c`	2026-08-30

Resistance mechanisms

1 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 1

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Mycobacterium tuberculosis ethA mutations conferring resistance to perchlozone	ARO:3005178	not organism-specific	—	ARO:3005178 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3005175 (perchlozone); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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