perchlozone

antibioticmech:aro-1c565a1a6c ·ANTIBACTERIAL ·MINTED SEEDED

Perchlozone is a novel thiosemicarbazone used for the treatment of multidrug-resistant tuberculosis. It is similar to thiacetazone with only a different side chain attached to the thiosemicarbazone moiety. Perchlozone is a prodrug that is activated by ethA and inhibits the HadABC complex. — PMID:25704063

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

thiosemicarbazone antibioticARO:3007161

Strictly broader compounds or drug classes this molecule belongs to.

ARO:3007161 ARO:3007161

Chemical structure

Computed structure properties
Molecular formula	C7H8N4S
Charge	0
Average mass	180.23 Da
Monoisotopic mass	180.04696745 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	QTSJJDIDTYFLFC-YHYXMXQVSA-N

SMILES

C1=CN=CC=C1/C=N\NC(=S)N

InChI

InChI=1S/C7H8N4S/c8-7(12)11-10-5-6-1-3-9-4-2-6/h1-5H,(H3,8,11,12)/b10-5-

Also called

4-thioureido-iminomethylpyridinium perchlorate (EXACT_SYNONYM)— aro

Cross-references

Equivalent identifiers for this same structure in other resources.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3005175`	perchlozone	`antibioticmech:aro-1c565a1a6c`	2026-08-30

Resistance mechanisms

1 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 1

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Mycobacterium tuberculosis ethA mutations conferring resistance to perchlozone	ARO:3005178	not organism-specific	—	ARO:3005178 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3005175 (perchlozone); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.