plazomicin

antibioticmech:aro-554b15fa7b ·ANTIBACTERIAL ·MINTED SEEDED

Plazomicin is a neoglycoside, or next-generation, aminoglycoside, that has been identified as a potentially useful agent to combat drug-resistant bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa. — PMID:21131322

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

aminoglycoside antibioticARO:0000016

Strictly broader compounds or drug classes this molecule belongs to.

aminoglycoside antibiotic ARO:0000016

Chemical structure

Computed structure properties
Molecular formula	C25H48N6O10
Charge	0
Average mass	592.7 Da
Monoisotopic mass	592.34319175 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	IYDYFVUFSPQPPV-PEXOCOHZSA-N

SMILES

C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H](CC=C(O3)CNCCO)N)N)NC(=O)[C@H](CCN)O)O

InChI

InChI=1S/C25H48N6O10/c1-25(37)11-38-24(18(35)21(25)29-2)41-20-15(31-22(36)16(33)5-6-26)9-14(28)19(17(20)34)40-23-13(27)4-3-12(39-23)10-30-7-8-32/h3,13-21,23-24,29-30,32-35,37H,4-11,26-28H2,1-2H3,(H,31,36)/t13-,14+,15-,16+,17+,18-,19-,20+,21-,23-,24-,25+/m1/s1

Also called

ACHN-490 (EXACT_SYNONYM)— aro

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3003675`	plazomicin	`antibioticmech:aro-554b15fa7b`	2026-08-30

Activity spectrum

Measured or curated activity against specific taxa. A number without a method is not an observation — every row here carries an assay.

3 observations · Browse all observations · Complete record (JSON.gz)

Activity observations
Organism	Activity	MIC	Disk diffusion	Assay	Strain	Sample/genome	Evidence
Klebsiella pneumoniae NCBITaxon:573	—	>8.0 mg/L	—	Broth microdilution plazomicin MIC; modal MIC reported; interpreted using FDA breakpoints per the CDC/FDA AR Isolate Bank Panel 1247 footnote.	1153	BioSample SAMN34111340	Evidence Page data (JSON.gz)
Klebsiella pneumoniae NCBITaxon:573	—	>8.0 mg/L	—	Broth microdilution plazomicin MIC; modal MIC reported; interpreted using FDA breakpoints per the CDC/FDA AR Isolate Bank Panel 1247 footnote.	1158	BioSample SAMN34111344	Evidence Page data (JSON.gz)
Klebsiella pneumoniae NCBITaxon:573	—	>8.0 mg/L	—	Broth microdilution plazomicin MIC; modal MIC reported; interpreted using FDA breakpoints per the CDC/FDA AR Isolate Bank Panel 1247 footnote.	1163	BioSample SAMN34111349	Evidence Page data (JSON.gz)

Resistance mechanisms

1 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_INACTIVATION 1

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
APH(2'')-IIa	ARO:3002635	not organism-specific	—	ARO:3002635 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003675 (plazomicin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
CURATED_RESISTANT_TAXA 2026-09-13 · codex · LLM-assisted
Added 3 stable-URL CDC/FDA AR Isolate Bank plazomicin-resistant Multi-Mechanism panel MIC observations for AR-1153, AR-1158, and AR-1163.
CURATED_RESISTANT_TAXA 2026-09-13 · codex · LLM-assisted
Corrected CDC/FDA AR Isolate Bank plazomicin activity observations to cite FDA breakpoints rather than CLSI M100 S35.
STRUCTURED_ACTIVITY_BIOSAMPLE_ACCESSIONS 2026-09-26 · codex · LLM-assisted
Structured BioSample accessions on 3 activity_spectrum observation(s) where evidence notes already named exactly one accession.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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