pleuromutilin
CHEBI:8269
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound. — PMID:23589420
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
pleuromutilin antibioticARO:3000670
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C22H34O5 |
|---|
| Charge | 0 |
|---|
| Average mass | 378.509 Da |
|---|
| Monoisotopic mass | 378.24062 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | ZRZNJUXESFHSIO-ZXVYJXQESA-N |
|---|
SMILES
[H][C@@]12C(=O)CC[C@]13CCC(C)[C@@]2(C)[C@H](OC(=O)CO)C[C@@](C)(C=C)[C@@H](O)[C@@H]3C
InChI
InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13?,14-,16+,18-,19-,20+,21-,22-/m0/s1
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3001317 |
pleuromutilin |
antibioticmech:aro-ac69007b2b |
2026-08-30 |
Resistance mechanisms
8 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_PROTECTION 6
ANTIBIOTIC_TARGET_PROTECTION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| eatAv |
ARO:3003761 |
not organism-specific |
— |
- ARO:3003761 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001317 (pleuromutilin); database assertion, not a primary citation.)
|
| lsaA |
ARO:3000300 |
not organism-specific |
— |
- ARO:3000300 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001317 (pleuromutilin); database assertion, not a primary citation.)
|
| lsaB |
ARO:3003111 |
not organism-specific |
— |
- ARO:3003111 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001317 (pleuromutilin); database assertion, not a primary citation.)
|
| lsaC |
ARO:3003112 |
not organism-specific |
— |
- ARO:3003112 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001317 (pleuromutilin); database assertion, not a primary citation.)
|
| lsaE |
ARO:3003206 |
not organism-specific |
— |
- ARO:3003206 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001317 (pleuromutilin); database assertion, not a primary citation.)
|
| tva(A) |
ARO:3004730 |
not organism-specific |
— |
- ARO:3004730 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001317 (pleuromutilin); database assertion, not a primary citation.)
|
ANTIBIOTIC_EFFLUX 1
ANTIBIOTIC_EFFLUX
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| TaeA |
ARO:3003986 |
not organism-specific |
— |
- ARO:3003986 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001317 (pleuromutilin); database assertion, not a primary citation.)
|
ANTIBIOTIC_TARGET_ALTERATION 1
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Mycoplasma gallisepticum 23S rRNA mutation conferring resistance to pleuromutilin antibiotics |
ARO:3004159 |
not organism-specific |
— |
- ARO:3004159 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001317 (pleuromutilin); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.