potassium clavulanate

CHEBI:85264 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A potassium salt having clavulanate as the counterion. It acts as a suicide inhibitor of bacterial β-lactamase enzymes and has only weak anitbiotic activity when administered alone. However it can be used in combination with amoxicillin trihydrate (under the trade name Augmentin) for treatment of a variety of bacterial infections, where it prevents antibiotic inactivation by microbial lactamases. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:26218 CHEBI:26218

Chemical structure

Computed structure properties
Molecular formula	C8H8NO5.K
Charge	0
Average mass	237.252 Da
Monoisotopic mass	237.00395 Da
Source	ChEBI
InChIKey	ABVRVIZBZKUTMK-JSYANWSFSA-M

SMILES

[H][C@@]12CC(=O)N1[C@@H](C(=O)[O-])/C(=C/CO)O2.[K+]

InChI

InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1

Also called

potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate (EXACT_SYNONYM)— chebi
CVA (EXACT_SYNONYM)— chebi
Clavulanate potassium (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:61177-45-5
drugbank:DB00766
kegg.drug:D02370
reaxys:4773605
wikipedia.en:Clavulanic_Acid

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281
CHEBI:36047 CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:85264`	potassium clavulanate	`antibioticmech:chebi-374e2fc32b`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.