AntibioticMech

Prulifloxacin

CHEBI:32071 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

Prulifloxacin is a 6-fluoroquinolone antibiotic with a C-2 sulfur atom. It is hydrolyzed by esterases to produce the active compound Ulifloxacin. The active compound has broad spectrum activity against most Gram-negative bacteria. Prulifloxacin displays strong bactericidal activity against Pseudomonas aeruginosa biofilms and persister cells. — PMID:1667252

Classification

fluoroquinolone antibioticARO:0000001

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:86324 CHEBI:86324
• CHEBI:87211 CHEBI:87211
• ARO:0000001 ARO:0000001

Chemical structure

Computed structure properties

Molecular formula	C21H20FN3O6S
Charge	0
Average mass	461.471 Da
Monoisotopic mass	461.10568 Da
Source	ChEBI
InChIKey	PWNMXPDKBYZCOO-UHFFFAOYSA-N

SMILES

Cc1oc(=O)oc1CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)c2n3C(C)S2)CC1

InChI

InChI=1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28)

Also called

• Sword (BRAND_NAME)— chebi
• prulifloxacine (INN)— chebi
• prulifloxacino (INN)— chebi
• NM-441 (EXACT_SYNONYM)— chebi
• NM441 (EXACT_SYNONYM)— chebi
• NSC-759833 (EXACT_SYNONYM)— chebi
• Pruvel (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• ARO:3007022
• cas:123447-62-1
• drugcentral:2325
• kegg.drug:D01144
• chembl:CHEMBL422648
• pubchem.compound:65947

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:33281 CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
ARO	ARO:3007022	prulifloxacin	antibioticmech:aro-55945eb69a	2026-08-30
CHEBI	CHEBI:32071	Prulifloxacin	antibioticmech:chebi-819fc798a8	2026-08-30

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO, CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.