Prulifloxacin

CHEBI:32071 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

Prulifloxacin is a 6-fluoroquinolone antibiotic with a C-2 sulfur atom. It is hydrolyzed by esterases to produce the active compound Ulifloxacin. The active compound has broad spectrum activity against most Gram-negative bacteria. Prulifloxacin displays strong bactericidal activity against Pseudomonas aeruginosa biofilms and persister cells. — PMID:1667252

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

fluoroquinolone antibioticARO:0000001

Strictly broader compounds or drug classes this molecule belongs to.

quinolone antibiotic CHEBI:86324
fluoroquinolone antibiotic CHEBI:87211
fluoroquinolone antibiotic ARO:0000001

Chemical structure

Computed structure properties
Molecular formula	C21H20FN3O6S
Charge	0
Average mass	461.471 Da
Monoisotopic mass	461.10568 Da
Source	ChEBI
InChIKey	PWNMXPDKBYZCOO-UHFFFAOYSA-N

SMILES

Cc1oc(=O)oc1CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)c2n3C(C)S2)CC1

InChI

InChI=1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28)

Also called

Sword (BRAND_NAME)— chebi
prulifloxacine (INN)— chebi
prulifloxacino (INN)— chebi
NM-441 (EXACT_SYNONYM)— chebi
NM441 (EXACT_SYNONYM)— chebi
NSC-759833 (EXACT_SYNONYM)— chebi
Pruvel (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antimicrobial agent CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3007022`	prulifloxacin	`antibioticmech:aro-55945eb69a`	2026-08-30
CHEBI	`CHEBI:32071`	Prulifloxacin	`antibioticmech:chebi-819fc798a8`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

Explore across X-Mech: MediaIngredientMech (Prulifloxacin) · CultureMech · NaturalProductMech · PathwayMech · TraitMech