pulvomycin
CHEBI:29668
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
Pulvomycin is a polyketide antibiotic that binds elongation factor Tu (EF-Tu) to inhibit protein biosynthesis by preventing the formation of the ternary complex (EF-Tu*GTP*aa-tRNA). Phenotypically, it was shown that pulvomycin sensitivity is dominant over resistance. — PMID:16734421
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
elfamycin antibioticARO:3001219
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C47H66O13 |
|---|
| Charge | 0 |
|---|
| Average mass | 839.032 Da |
|---|
| Monoisotopic mass | 838.45034 Da |
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| Source | ChEBI |
|---|
| InChIKey | FXSFWUNCIOIMAC-YHQXOMPPSA-N |
|---|
SMILES
CO[C@@H]1[C@H](O)[C@@H](OC)[C@H](OC(C)C(O)/C=C/C=C/C=C/C(=O)C(C)C(O)C(C)C2C/C=C/C=C/C=C/C(O)C(=O)/C(C)=C/C=C/C(C)=C/C(O)/C(C)=C\CC(=O)O2)O[C@@H]1C
InChI
InChI=1S/C47H66O13/c1-29-20-19-21-31(3)42(53)38(50)24-17-11-10-12-18-25-40(60-41(52)27-26-30(2)39(51)28-29)33(5)43(54)32(4)36(48)22-15-13-14-16-23-37(49)34(6)58-47-46(57-9)44(55)45(56-8)35(7)59-47/h10-24,26,28,32-35,37-40,43-47,49-51,54-55H,25,27H2,1-9H3/b11-10+,14-13+,18-12+,20-19+,22-15+,23-16+,24-17+,29-28+,30-26-,31-21+/t32?,33?,34?,35-,37?,38?,39?,40?,43?,44+,45+,46-,47-/m1/s1
Also called
- Labilomycin (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3000586 |
pulvomycin |
antibioticmech:aro-d399f91ea7 |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
elongation factor Tu PROTEIN DIRECT_BINDING_TARGET
ARO:3000731
CARD/ARO database assertion; target organism, strain, and assay are not specified. Elongation factor Tu is asserted as the antibiotic target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000731 (CARD/ARO asserts targeted_by_antibiotic ARO:3000586 (pulvomycin); database assertion, not a primary citation.)
Resistance mechanisms
1 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 1
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin |
ARO:3003369 |
not organism-specific |
— |
- ARO:3003369 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000586 (pulvomycin); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.