quinupristin
CHEBI:8732
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis. — PMID:9746015
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
streptogramin antibioticARO:0000026
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C53H67N9O10S |
|---|
| Charge | 0 |
|---|
| Average mass | 1022.239 Da |
|---|
| Monoisotopic mass | 1021.47316 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | WTHRRGMBUAHGNI-MJWHERSYSA-N |
|---|
SMILES
[H][C@@]12CCCN1C(=O)[C@@H](CC)NC(=O)[C@@H](NC(=O)c1ncccc1O)[C@@H](C)OC(=O)[C@H](c1ccccc1)NC(=O)C1CC(=O)C(CS[C@@H]3CN4CCC3CC4)CN1C(=O)[C@H](Cc1ccc(N(C)C)cc1)N(C)C2=O
InChI
InChI=1S/C53H67N9O10S/c1-6-37-50(68)61-23-11-14-38(61)51(69)59(5)40(26-32-16-18-36(19-17-32)58(3)4)52(70)62-28-35(30-73-43-29-60-24-20-33(43)21-25-60)42(64)27-39(62)47(65)57-45(34-12-8-7-9-13-34)53(71)72-31(2)44(48(66)55-37)56-49(67)46-41(63)15-10-22-54-46/h7-10,12-13,15-19,22,31,33,35,37-40,43-45,63H,6,11,14,20-21,23-30H2,1-5H3,(H,55,66)(H,56,67)(H,57,65)/t31-,35?,37-,38+,39?,40+,43-,44+,45+/m1/s1
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3000584 |
quinupristin |
antibioticmech:aro-edd182646d |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
antibiotic sensitive peptidyl transferase (23S rRNA) NUCLEIC_ACID DIRECT_BINDING_TARGET
ARO:3000754
CARD/ARO database assertion; target organism, strain, and assay are not specified. 23S rRNA peptidyl-transferase center is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000754 (CARD/ARO asserts targeted_by_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
Resistance mechanisms
28 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 21
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Erm(33) |
ARO:3000599 |
not organism-specific |
— |
- ARO:3000599 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| Erm(34) |
ARO:3000600 |
not organism-specific |
— |
- ARO:3000600 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| Erm(35) |
ARO:3000604 |
not organism-specific |
— |
- ARO:3000604 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| Erm(36) |
ARO:3000605 |
not organism-specific |
— |
- ARO:3000605 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| Erm(37) |
ARO:3000392 |
not organism-specific |
— |
- ARO:3000392 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| Erm(38) |
ARO:3000601 |
not organism-specific |
— |
- ARO:3000601 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| Erm(39) |
ARO:3000602 |
not organism-specific |
— |
- ARO:3000602 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| Erm(41) |
ARO:3000603 |
not organism-specific |
— |
- ARO:3000603 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| Erm(47) |
ARO:3003908 |
not organism-specific |
— |
- ARO:3003908 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmA |
ARO:3000347 |
not organism-specific |
— |
- ARO:3000347 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmB |
ARO:3000375 |
not organism-specific |
— |
- ARO:3000375 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmC |
ARO:3000250 |
not organism-specific |
— |
- ARO:3000250 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmD |
ARO:3000495 |
not organism-specific |
— |
- ARO:3000495 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmE |
ARO:3000326 |
not organism-specific |
— |
- ARO:3000326 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmF |
ARO:3000498 |
not organism-specific |
— |
- ARO:3000498 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmG |
ARO:3000522 |
not organism-specific |
— |
- ARO:3000522 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmN |
ARO:3000592 |
not organism-specific |
— |
- ARO:3000592 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmQ |
ARO:3000593 |
not organism-specific |
— |
- ARO:3000593 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmR |
ARO:3000594 |
not organism-specific |
— |
- ARO:3000594 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmT |
ARO:3000595 |
not organism-specific |
— |
- ARO:3000595 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| ErmX |
ARO:3000596 |
not organism-specific |
— |
- ARO:3000596 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
ANTIBIOTIC_TARGET_PROTECTION 4
ANTIBIOTIC_TARGET_PROTECTION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| lsaA |
ARO:3000300 |
not organism-specific |
— |
- ARO:3000300 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| msrA |
ARO:3000251 |
not organism-specific |
— |
- ARO:3000251 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| msrB |
ARO:3002818 |
not organism-specific |
— |
- ARO:3002818 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| msrC |
ARO:3002819 |
not organism-specific |
— |
- ARO:3002819 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
ANTIBIOTIC_INACTIVATION 3
ANTIBIOTIC_INACTIVATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| vgbA |
ARO:3001307 |
not organism-specific |
— |
- ARO:3001307 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| vgbB |
ARO:3001308 |
not organism-specific |
— |
- ARO:3001308 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
| vgbC |
ARO:3003990 |
not organism-specific |
— |
- ARO:3003990 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000584 (quinupristin); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.