AntibioticMech

retapamulin

antibioticmech:aro-556deb5a30 ·ANTIBACTERIAL ·MINTED SEEDED

Retapamulin is a semi-synthetic pleuromutilin antibiotic approved for the treatment of skin infections. — PMID:17360517

Classification

pleuromutilin antibioticARO:3000670

Strictly broader compounds or drug classes this molecule belongs to.

• ARO:3000670 ARO:3000670

Chemical structure

Computed structure properties

Molecular formula	C30H47NO4S
Charge	0
Average mass	517.8 Da
Monoisotopic mass	517.32258015 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	STZYTFJPGGDRJD-FJJJPKKESA-N

SMILES

C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CSC4C[C@H]5CC[C@@H](C4)N5C)C

InChI

InChI=1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1

Cross-references

Equivalent identifiers for this same structure in other resources.

• ARO:3001314
• CHEBI:166679
• chembl:CHEMBL1658
• pubchem.compound:6918462

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
ARO	ARO:3001314	retapamulin	antibioticmech:aro-556deb5a30	2026-08-30

Resistance mechanisms

10 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_PROTECTION 10

ANTIBIOTIC_TARGET_PROTECTION

Determinant	ARO ID	Organism	Gene families	Evidence
Clostridium perfringes cplR	ARO:3007644	not organism-specific	—	ARO:3007644 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001314 (retapamulin); database assertion, not a primary citation.)
Clostridium sporogenes cplR	ARO:3007645	not organism-specific	—	ARO:3007645 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001314 (retapamulin); database assertion, not a primary citation.)
Neobacillus vireti vmlR2	ARO:3007646	not organism-specific	—	ARO:3007646 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001314 (retapamulin); database assertion, not a primary citation.)
salA	ARO:3003749	not organism-specific	—	ARO:3003749 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001314 (retapamulin); database assertion, not a primary citation.)
salB	ARO:3007026	not organism-specific	—	ARO:3007026 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001314 (retapamulin); database assertion, not a primary citation.)
salC	ARO:3007027	not organism-specific	—	ARO:3007027 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001314 (retapamulin); database assertion, not a primary citation.)
salD	ARO:3007028	not organism-specific	—	ARO:3007028 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001314 (retapamulin); database assertion, not a primary citation.)
salE	ARO:3007029	not organism-specific	—	ARO:3007029 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001314 (retapamulin); database assertion, not a primary citation.)
vga(E) Staphylococcus cohnii	ARO:3004715	not organism-specific	—	ARO:3004715 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001314 (retapamulin); database assertion, not a primary citation.)
vmlR	ARO:3004476	not organism-specific	—	ARO:3004476 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3001314 (retapamulin); database assertion, not a primary citation.)

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.