ribostamycin

CHEBI:45257 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-α-D-glucosyl residue attached at position 1 and a β-D-ribosyl residue attached at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus). — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

aminoglycoside antibioticARO:0000016

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:22479
aminoglycoside antibiotic CHEBI:22507
aminoglycoside antibiotic ARO:0000016

Chemical structure

Computed structure properties
Molecular formula	C17H34N4O10
Charge	0
Average mass	454.477 Da
Monoisotopic mass	454.22749 Da
Source	ChEBI
InChIKey	NSKGQURZWSPSBC-VVPCINPTSA-N

SMILES

[H][C@@]1(O[C@@H]2[C@@H](O)[C@H](N)C[C@H](N)[C@H]2O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N)O[C@H](CO)[C@@H](O)[C@H]1O

InChI

InChI=1S/C17H34N4O10/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17/h4-17,22-27H,1-3,18-21H2/t4-,5+,6-,7-,8-,9+,10-,11-,12-,13-,14-,15-,16-,17+/m1/s1

Also called

ribostamicina (INN)— chebi
ribostamycine (INN)— chebi
ribostamycinum (INN)— chebi
(1R,2R,3R,4R,6S)-4,6-diamino-3-hydroxy-2-(β-D-ribofuranosyloxy)cyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside (EXACT_SYNONYM)— chebi
RIBOSTAMYCIN (EXACT_SYNONYM)— chebi
SF-733 (EXACT_SYNONYM)— chebi
Vistamycin (EXACT_SYNONYM)— chebi
antibiotic SF 733 (EXACT_SYNONYM)— chebi
ribostamycin A (EXACT_SYNONYM)— chebi
dekamycin IV (EXACT_SYNONYM)— aro
hetangmycin (EXACT_SYNONYM)— aro
ribastamin (EXACT_SYNONYM)— aro
vistamycin (EXACT_SYNONYM)— aro
xylostatin (EXACT_SYNONYM)— aro

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antimicrobial agent CHEBI:33281
antibacterial drug CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:0000021`	ribostamycin	`antibioticmech:aro-ce5183caf1`	2026-08-30
CHEBI	`CHEBI:45257`	ribostamycin	`antibioticmech:chebi-9ae06cba97`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000755

CARD/ARO database assertion; target organism, strain, and assay are not specified. 16S rRNA is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000755 (CARD/ARO asserts targeted_by_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)

Resistance mechanisms

14 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_INACTIVATION 13

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
AAC(6')-Va	ARO:3009655	not organism-specific	—	ARO:3009655 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-IIIa	ARO:3002647	not organism-specific	—	ARO:3002647 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-IIa	ARO:3002644	not organism-specific	—	ARO:3002644 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-IIb	ARO:3002645	not organism-specific	—	ARO:3002645 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-IIc	ARO:3002646	not organism-specific	—	ARO:3002646 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-IVa	ARO:3002648	not organism-specific	—	ARO:3002648 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-Ia	ARO:3002641	not organism-specific	—	ARO:3002641 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-Ib	ARO:3002642	not organism-specific	—	ARO:3002642 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-VIa	ARO:3002652	not organism-specific	—	ARO:3002652 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-VIb	ARO:3002653	not organism-specific	—	ARO:3002653 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-Va	ARO:3002649	not organism-specific	—	ARO:3002649 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-Vb	ARO:3002650	not organism-specific	—	ARO:3002650 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-Vc	ARO:3002651	not organism-specific	—	ARO:3002651 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_ALTERATION 1

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
npmA	ARO:3002665	not organism-specific	—	ARO:3002665 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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