AntibioticMech

ribostamycin

CHEBI:45257 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-α-D-glucosyl residue attached at position 1 and a β-D-ribosyl residue attached at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus). — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

aminoglycoside antibioticARO:0000016

Strictly broader compounds or drug classes this molecule belongs to.

Chemical structure

Computed structure properties
Molecular formulaC17H34N4O10
Charge0
Average mass454.477 Da
Monoisotopic mass454.22749 Da
SourceChEBI
InChIKeyNSKGQURZWSPSBC-VVPCINPTSA-N

SMILES

[H][C@@]1(O[C@@H]2[C@@H](O)[C@H](N)C[C@H](N)[C@H]2O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N)O[C@H](CO)[C@@H](O)[C@H]1O

InChI

InChI=1S/C17H34N4O10/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17/h4-17,22-27H,1-3,18-21H2/t4-,5+,6-,7-,8-,9+,10-,11-,12-,13-,14-,15-,16-,17+/m1/s1

Also called

Cross-references

Equivalent identifiers for this same structure in other resources.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
SourceNative IDLabelMinted CURIEVersion
ARO ARO:0000021 ribostamycin antibioticmech:aro-ce5183caf1 2026-08-30
CHEBI CHEBI:45257 ribostamycin antibioticmech:chebi-9ae06cba97 2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000755

CARD/ARO database assertion; target organism, strain, and assay are not specified. 16S rRNA is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

Resistance mechanisms

14 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_INACTIVATION 13
ANTIBIOTIC_INACTIVATION
DeterminantARO IDOrganismGene familiesEvidence
AAC(6')-Va ARO:3009655 not organism-specific —
  • ARO:3009655 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-IIIa ARO:3002647 not organism-specific —
  • ARO:3002647 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-IIa ARO:3002644 not organism-specific —
  • ARO:3002644 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-IIb ARO:3002645 not organism-specific —
  • ARO:3002645 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-IIc ARO:3002646 not organism-specific —
  • ARO:3002646 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-IVa ARO:3002648 not organism-specific —
  • ARO:3002648 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-Ia ARO:3002641 not organism-specific —
  • ARO:3002641 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-Ib ARO:3002642 not organism-specific —
  • ARO:3002642 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-VIa ARO:3002652 not organism-specific —
  • ARO:3002652 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-VIb ARO:3002653 not organism-specific —
  • ARO:3002653 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-Va ARO:3002649 not organism-specific —
  • ARO:3002649 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-Vb ARO:3002650 not organism-specific —
  • ARO:3002650 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
APH(3')-Vc ARO:3002651 not organism-specific —
  • ARO:3002651 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)
ANTIBIOTIC_TARGET_ALTERATION 1
ANTIBIOTIC_TARGET_ALTERATION
DeterminantARO IDOrganismGene familiesEvidence
npmA ARO:3002665 not organism-specific —
  • ARO:3002665 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000021 (ribostamycin); database assertion, not a primary citation.)

Curation history

  1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Seeded from data/raw/ inventories (ARO, CHEBI)

  2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.