(S)-nadifloxacin

CHEBI:37908 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A novel broad-spectrum anti-MRSA benzoquinolizine antibiotic effective against gram-positive and gram-negative pathogens. — PMID:31920285

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

fluoroquinolone antibioticARO:0000001

Strictly broader compounds or drug classes this molecule belongs to.

nadifloxacin CHEBI:31889
fluoroquinolone antibiotic ARO:0000001

Chemical structure

Computed structure properties
Molecular formula	C19H21FN2O4
Charge	0
Average mass	360.385 Da
Monoisotopic mass	360.14854 Da
Source	ChEBI
InChIKey	JYJTVFIEFKZWCJ-JTQLQIEISA-N

SMILES

C[C@H]1CCc2c(N3CCC(O)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23

InChI

InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)/t10-/m0/s1

Also called

(5S)-9-fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

levonadifloxacinARO:3005120
beilstein:7084299
pubchem.compound:9850038

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antimicrobial agent CHEBI:33281
antibacterial drug CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3005120`	levonadifloxacin	`antibioticmech:aro-6c3d2579b5`	2026-08-30
CHEBI	`CHEBI:37908`	(S)-nadifloxacin	`antibioticmech:chebi-b0f94261f2`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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