streptothricin F
CHEBI:60821
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
A streptothricin in which the peptide side-chain consists of a single unit of β-lysine. — ChEBI
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
nucleoside antibioticARO:3000034
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C19H34N8O8 |
|---|
| Charge | 0 |
|---|
| Average mass | 502.529 Da |
|---|
| Monoisotopic mass | 502.24996 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | NRAUADCLPJTGSF-VLSXYIQESA-N |
|---|
SMILES
[H][C@]12N/C(=N/[C@@H]3O[C@H](CO)[C@H](OC(N)=O)[C@@H](O)[C@H]3NC(=O)C[C@@H](N)CCCN)N[C@]1([H])[C@H](O)CNC2=O
InChI
InChI=1S/C19H34N8O8/c20-3-1-2-7(21)4-10(30)24-13-14(31)15(35-18(22)33)9(6-28)34-17(13)27-19-25-11-8(29)5-23-16(32)12(11)26-19/h7-9,11-15,17,28-29,31H,1-6,20-21H2,(H2,22,33)(H,23,32)(H,24,30)(H2,25,26,27)/t7-,8+,9+,11+,12-,13+,14-,15-,17+/m0/s1
Also called
- 4-O-carbamoyl-2-deoxy-2-{[(3S)-3,6-diaminohexanoyl]amino}-N-[(3aS,7R,7aS)-7-hydroxy-4-oxooctahydro-2H-imidazo[4,5-c]pyridin-2-ylidene]-β-D-gulopyranosylamine (EXACT_SYNONYM)— chebi
- antibiotic S 15-1A (EXACT_SYNONYM)— chebi
- racemomycin A (EXACT_SYNONYM)— chebi
- streptothricin (EXACT_SYNONYM)— chebi
- streptothricin VI (EXACT_SYNONYM)— chebi
- yazumycin A (EXACT_SYNONYM)— chebi
- nourseothricin (EXACT_SYNONYM)— aro
- racemomycin (EXACT_SYNONYM)— aro
- yazumycin (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Activity roles
Every antimicrobial role a source asserts for this compound — the
unreduced evidence behind its antimicrobial_class.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:0000012 |
streptothricin |
antibioticmech:aro-ede1146b16 |
2026-08-30 |
| CHEBI |
CHEBI:60821 |
streptothricin F |
antibioticmech:chebi-c4e9f9eac8 |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET
ARO:3000755
CARD/ARO database assertion; target organism, strain, and assay are not specified. 16S rRNA is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000755 (CARD/ARO asserts targeted_by_antibiotic ARO:0000012 (streptothricin); database assertion, not a primary citation.)
Resistance mechanisms
5 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_INACTIVATION 5
ANTIBIOTIC_INACTIVATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| SAT-2 |
ARO:3002895 |
not organism-specific |
— |
- ARO:3002895 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000012 (streptothricin); database assertion, not a primary citation.)
|
| SAT-3 |
ARO:3002898 |
not organism-specific |
— |
- ARO:3002898 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000012 (streptothricin); database assertion, not a primary citation.)
|
| SAT-4 |
ARO:3002897 |
not organism-specific |
— |
- ARO:3002897 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000012 (streptothricin); database assertion, not a primary citation.)
|
| SatA |
ARO:3005045 |
not organism-specific |
— |
- ARO:3005045 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000012 (streptothricin); database assertion, not a primary citation.)
|
| sta |
ARO:3004699 |
not organism-specific |
— |
- ARO:3004699 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000012 (streptothricin); database assertion, not a primary citation.)
|
Producer organisms
Organisms that biosynthesize this compound.
Producer organisms
| Organism | BGC | Source | Quality | Note | Evidence |
|---|
Streptomyces rochei NCBITaxon:1928
strain NBRC 12908 |
BGC0000432 |
MIBIG 4.0.1 (entry 6); reviewed |
questionable |
MIBiG active entry with a non-placeholder expert reviewer; compound 'streptothricin F' joined by exact Standard InChIKey. |
- PMID:22820420 (MIBiG's first legacy reference for the entry, inherited rather than attached to the compound. It supports that the entry exists; it is NOT established as evidence for this specific producer/compound link.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-09-03 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.