sulfisoxazole

CHEBI:102484 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

sulfonamide antibioticARO:3000282

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:35358
Label unavailable CHEBI:55373
sulfonamide antibiotic CHEBI:87228
sulfonamide antibiotic ARO:3000282

Chemical structure

Computed structure properties
Molecular formula	C11H13N3O3S
Charge	0
Average mass	267.31 Da
Monoisotopic mass	267.06776 Da
Source	ChEBI
InChIKey	NHUHCSRWZMLRLA-UHFFFAOYSA-N

SMILES

Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C

InChI

InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3

Also called

sulfafurazole (INN)— chebi
sulfafurazolum (INN)— chebi
4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide (EXACT_SYNONYM)— chebi
3,4-Dimethyl-5-sulfanilamidoisoxazole (EXACT_SYNONYM)— chebi
3,4-Dimethyl-5-sulfonamidoisoxazole (EXACT_SYNONYM)— chebi
3,4-Dimethyl-5-sulphanilamidoisoxazole (EXACT_SYNONYM)— chebi
3,4-Dimethyl-5-sulphonamidoisoxazole (EXACT_SYNONYM)— chebi
3,4-Dimethylisoxazole-5-sulfanilamide (EXACT_SYNONYM)— chebi
3,4-Dimethylisoxazole-5-sulphanilamide (EXACT_SYNONYM)— chebi
4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide (EXACT_SYNONYM)— chebi
4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide (EXACT_SYNONYM)— chebi
5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole (EXACT_SYNONYM)— chebi
5-(p-Aminobenzenesulfonamido)-3,4-dimethylisoxazole (EXACT_SYNONYM)— chebi
5-(p-Aminobenzenesulphonamido)-3,4-dimethylisoxazole (EXACT_SYNONYM)— chebi
5-Sulfanilamido-3,4-dimethylisoxazole (EXACT_SYNONYM)— chebi
5-Sulphanilamido-3,4-dimethyl-isoxazole (EXACT_SYNONYM)— chebi
N'-(3,4)Dimethylisoxazol-5-yl-sulphanilamide (EXACT_SYNONYM)— chebi
N1-(3,4-dimethyl-5-isoxazolyl)sulfanilamide (EXACT_SYNONYM)— chebi
N1-(3,4-dimethyl-5-isoxazolyl)sulphanilamide (EXACT_SYNONYM)— chebi
Sulfadimethylisoxazole (EXACT_SYNONYM)— chebi
Sulfafurazol (EXACT_SYNONYM)— chebi
Sulfaisoxazole (EXACT_SYNONYM)— chebi
Sulfasoxazole (EXACT_SYNONYM)— chebi
Sulfisonazole (EXACT_SYNONYM)— chebi
Sulfisoxasole (EXACT_SYNONYM)— chebi
Sulfisoxazol (EXACT_SYNONYM)— chebi
Sulfofurazole (EXACT_SYNONYM)— chebi
Sulphadimethylisoxazole (EXACT_SYNONYM)— chebi
Sulphafurazol (EXACT_SYNONYM)— chebi
Sulphafurazole (EXACT_SYNONYM)— chebi
Sulphaisoxazole (EXACT_SYNONYM)— chebi
Sulphisoxazol (EXACT_SYNONYM)— chebi
Sulphofurazole (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antimicrobial agent CHEBI:33281
antibacterial drug CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3000330`	sulfisoxazole	`antibioticmech:aro-532eb18065`	2026-08-30
CHEBI	`CHEBI:102484`	sulfisoxazole	`antibioticmech:chebi-6e3f755bcb`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive dihydropteroate synthase PROTEIN DIRECT_BINDING_TARGET

ARO:3000744

CARD/ARO database assertion; target organism, strain, and assay are not specified. Dihydropteroate synthase is asserted as the inhibited enzyme. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000744 (CARD/ARO asserts targeted_by_antibiotic ARO:3000330 (sulfisoxazole); database assertion, not a primary citation.)

Mechanism summary

Clinical status: APPROVED

Resistance mechanisms

6 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 3

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Escherichia coli folP with mutation conferring resistance to sulfonamides	ARO:3003386	not organism-specific	—	ARO:3003386 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000330 (sulfisoxazole); database assertion, not a primary citation.)
Neisseria gonorrhoeae folP with mutation conferring resistance to sulfonamides	ARO:3004873	not organism-specific	—	ARO:3004873 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000330 (sulfisoxazole); database assertion, not a primary citation.)
Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides	ARO:3003387	not organism-specific	—	ARO:3003387 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000330 (sulfisoxazole); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_REPLACEMENT 3

ANTIBIOTIC_TARGET_REPLACEMENT
Determinant	ARO ID	Organism	Gene families	Evidence
sul1	ARO:3000410	not organism-specific	—	ARO:3000410 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000330 (sulfisoxazole); database assertion, not a primary citation.)
sul2	ARO:3000412	not organism-specific	—	ARO:3000412 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000330 (sulfisoxazole); database assertion, not a primary citation.)
sul3	ARO:3000413	not organism-specific	—	ARO:3000413 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000330 (sulfisoxazole); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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