telithromycin
CHEBI:29688
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
Telithromycin is a semi-synthetic derivative of erythromycin. It is a 14-membered macrolide and is the first ketolide antibiotic to be used in clinics. Telithromycin binds the 50S subunit of the bacterial ribosome to inhibit protein synthesis. — PMID:15700954
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
macrolide antibioticARO:0000000
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C43H65N5O10 |
|---|
| Charge | 0 |
|---|
| Average mass | 812.018 Da |
|---|
| Monoisotopic mass | 811.47314 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | LJVAJPDWBABPEJ-PNUFFHFMSA-N |
|---|
SMILES
[H][C@]1(C)C(=O)O[C@H](CC)[C@@]2(C)OC(=O)N(CCCCn3cnc(-c4cccnc4)c3)[C@]2([H])[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@]2([H])O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)C1=O
InChI
InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1
Also called
- HMR-3647 (EXACT_SYNONYM)— aro
- HMR3647 (EXACT_SYNONYM)— aro
- Ketek (EXACT_SYNONYM)— aro
- Levviax (EXACT_SYNONYM)— aro
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:0000057 |
telithromycin |
antibioticmech:aro-4e703afb24 |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
50S ribosomal subunit P-site RIBOSOMAL_SUBUNIT DIRECT_BINDING_TARGET
ARO:3000757
CARD/ARO database assertion; target organism, strain, and assay are not specified. The 50S P-site is asserted as the target site. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000757 (CARD/ARO asserts targeted_by_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
Mechanism summary
- Clinical status
- APPROVED
Resistance mechanisms
30 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 22
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Erm(33) |
ARO:3000599 |
not organism-specific |
— |
- ARO:3000599 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| Erm(34) |
ARO:3000600 |
not organism-specific |
— |
- ARO:3000600 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| Erm(35) |
ARO:3000604 |
not organism-specific |
— |
- ARO:3000604 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| Erm(36) |
ARO:3000605 |
not organism-specific |
— |
- ARO:3000605 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| Erm(37) |
ARO:3000392 |
not organism-specific |
— |
- ARO:3000392 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| Erm(38) |
ARO:3000601 |
not organism-specific |
— |
- ARO:3000601 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| Erm(39) |
ARO:3000602 |
not organism-specific |
— |
- ARO:3000602 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| Erm(41) |
ARO:3000603 |
not organism-specific |
— |
- ARO:3000603 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmA |
ARO:3000347 |
not organism-specific |
— |
- ARO:3000347 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmB |
ARO:3000375 |
not organism-specific |
— |
- ARO:3000375 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmC |
ARO:3000250 |
not organism-specific |
— |
- ARO:3000250 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmD |
ARO:3000495 |
not organism-specific |
— |
- ARO:3000495 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmE |
ARO:3000326 |
not organism-specific |
— |
- ARO:3000326 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmF |
ARO:3000498 |
not organism-specific |
— |
- ARO:3000498 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmG |
ARO:3000522 |
not organism-specific |
— |
- ARO:3000522 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmN |
ARO:3000592 |
not organism-specific |
— |
- ARO:3000592 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmQ |
ARO:3000593 |
not organism-specific |
— |
- ARO:3000593 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmR |
ARO:3000594 |
not organism-specific |
— |
- ARO:3000594 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmT |
ARO:3000595 |
not organism-specific |
— |
- ARO:3000595 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| ErmX |
ARO:3000596 |
not organism-specific |
— |
- ARO:3000596 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin |
ARO:3004131 |
not organism-specific |
— |
- ARO:3004131 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics |
ARO:3004176 |
not organism-specific |
— |
- ARO:3004176 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
ANTIBIOTIC_INACTIVATION 6
ANTIBIOTIC_INACTIVATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| mphA |
ARO:3000316 |
not organism-specific |
— |
- ARO:3000316 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| mphB |
ARO:3000318 |
not organism-specific |
— |
- ARO:3000318 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| mphC |
ARO:3000319 |
not organism-specific |
— |
- ARO:3000319 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| mphI |
ARO:3003991 |
not organism-specific |
— |
- ARO:3003991 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| mphJ |
ARO:3004544 |
not organism-specific |
— |
- ARO:3004544 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
| mphK |
ARO:3004541 |
not organism-specific |
— |
- ARO:3004541 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
ANTIBIOTIC_EFFLUX 1
ANTIBIOTIC_EFFLUX
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Enterobacter cloacae rob |
ARO:3004108 |
not organism-specific |
— |
- ARO:3004108 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
ANTIBIOTIC_TARGET_PROTECTION 1
ANTIBIOTIC_TARGET_PROTECTION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| mel |
ARO:3000616 |
not organism-specific |
— |
- ARO:3000616 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000057 (telithromycin); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.