tetracycline

CHEBI:27902 ·resolve ·ANTIBACTERIAL ·EXACT REVIEWED

A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria. — ChEBI

Classification

tetracycline antibioticARO:3000050

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:139592
Label unavailable CHEBI:26895
tetracycline antibiotic ARO:3000050

Chemical structure

Computed structure properties
Molecular formula	C22H24N2O8
Charge	0
Average mass	444.44 Da
Monoisotopic mass	444.15327 Da
Source	ChEBI
InChIKey	OFVLGDICTFRJMM-WESIUVDSSA-N

SMILES

[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c1c(O)cccc1[C@@]2(C)O

InChI

InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

Also called

Achromycin (BRAND_NAME)— chebi
tetracyclinum (INN)— chebi
(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (EXACT_SYNONYM)— chebi
(4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide (EXACT_SYNONYM)— chebi
Abramycin (EXACT_SYNONYM)— chebi
Anhydrotetracycline (EXACT_SYNONYM)— chebi
Deschlorobiomycin (EXACT_SYNONYM)— chebi
Liquamycin (EXACT_SYNONYM)— chebi
TETRACYCLINE (EXACT_SYNONYM)— chebi
Tetracyclin (EXACT_SYNONYM)— chebi
Tetracycline (EXACT_SYNONYM)— chebi
Tetrazyklin (EXACT_SYNONYM)— chebi
Tsiklomitsin (EXACT_SYNONYM)— chebi
tétracycline (EXACT_SYNONYM)— chebi
Abricycline (EXACT_SYNONYM)— aro
Agromicina (EXACT_SYNONYM)— aro
Ambramicina (EXACT_SYNONYM)— aro
Ambramycin (EXACT_SYNONYM)— aro
Biocycline (EXACT_SYNONYM)— aro
Criseociclina (EXACT_SYNONYM)— aro
Enterocycline (EXACT_SYNONYM)— aro
Sumycin (EXACT_SYNONYM)— aro
Tsiklomistsin (EXACT_SYNONYM)— aro

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antimicrobial agent CHEBI:33281
antiprotozoal drug CHEBI:35820
antibacterial drug CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:0000051`	tetracycline	`antibioticmech:aro-09e5b9b202`	2026-08-30
CHEBI	`CHEBI:27902`	tetracycline	`antibioticmech:chebi-6566023480`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000755

CARD/ARO database assertion; target organism, strain, and assay are not specified. 16S rRNA is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000755 (CARD/ARO asserts targeted_by_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)

30S ribosomal subunit RIBOSOMAL_SUBUNIT DIRECT_BINDING_TARGET

Atomic structures of antibiotic-30S complexes directly localized tetracycline at discrete small-subunit binding sites and supported the functional mechanism. Evidence status: PRIMARY_EVIDENCE. Source: PRIMARY_LITERATURE 2000-12 (retrieved 2026-09-02).

PMID:11163189 (Primary tetracycline-bound 30S structural mechanism study (DOI:10.1016/S0092-8674(00)00216-6).)

Mechanism summary

Mode of action: PROTEIN_SYNTHESIS_INHIBITION host shared target — CURATOR: PMID:11163189 determined the atomic structure of tetracycline bound at discrete sites on the bacterial 30S ribosomal subunit. The observed drug-ribosome interactions support inhibition of aminoacyl-tRNA delivery and therefore bacterial protein synthesis.

Activity spectrum

Measured or curated activity against specific taxa. A number without a method is not an observation — every row here carries an assay.

20 observations · Browse all observations · Complete record (JSON.gz)

Activity observations
Organism	Activity	MIC	Disk diffusion	Assay	Strain	Sample/genome	Evidence
Escherichia coli NCBITaxon:562	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	0349	BioSample SAMN11953777	Evidence Page data (JSON.gz)
Klebsiella pneumoniae NCBITaxon:573	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	0497	BioSample SAMN11953783	Evidence Page data (JSON.gz)
Acinetobacter baumannii NCBITaxon:470	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2024 M100 S34.	0297	BioSample SAMN04901687	Evidence Page data (JSON.gz)
Escherichia coli NCBITaxon:562	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	0346	BioSample SAMN11953774	Evidence Page data (JSON.gz)
Escherichia coli NCBITaxon:562	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	1305	BioSample SAMN46941623	Evidence Page data (JSON.gz)
Klebsiella pneumoniae NCBITaxon:573	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	1149	BioSample SAMN34111336	Evidence Page data (JSON.gz)
Enterobacter cloacae complex NCBITaxon:354276	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	1151	BioSample SAMN34111338	Evidence Page data (JSON.gz)
Enterobacter cloacae complex NCBITaxon:354276	—	32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	1152	BioSample SAMN34111339	Evidence Page data (JSON.gz)
Klebsiella pneumoniae NCBITaxon:573	—	16.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	1153	BioSample SAMN34111340	Evidence Page data (JSON.gz)
Enterobacter cloacae complex NCBITaxon:354276	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	1160	BioSample SAMN34111346	Evidence Page data (JSON.gz)
Escherichia coli NCBITaxon:562	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	1162	BioSample SAMN34111348	Evidence Page data (JSON.gz)
Klebsiella pneumoniae NCBITaxon:573	—	16.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	1163	BioSample SAMN34111349	Evidence Page data (JSON.gz)
Staphylococcus aureus NCBITaxon:1280	—	>16.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	0701	BioSample SAMN11953851	Evidence Page data (JSON.gz)
Staphylococcus aureus NCBITaxon:1280	—	>16.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	0702	BioSample SAMN11953852	Evidence Page data (JSON.gz)
Neisseria gonorrhoeae NCBITaxon:485	—	2.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2026 M100 Ed36.	1280	BioSample SAMN35332250	Evidence Page data (JSON.gz)
Neisseria gonorrhoeae NCBITaxon:485	—	2.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2026 M100 Ed36.	1281	BioSample SAMN35332251	Evidence Page data (JSON.gz)
Escherichia coli NCBITaxon:562	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35.	0495	BioSample SAMN11953781	Evidence Page data (JSON.gz)
Acinetobacter baumannii NCBITaxon:470	—	32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2024 M100 S34 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0078	BioSample SAMN04014919	Evidence Page data (JSON.gz)
Acinetobacter baumannii NCBITaxon:470	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2020 M100 S30 per the CDC/FDA AR Isolate Bank Panel 1227 footnote.	0083	BioSample SAMN04014924	Evidence Page data (JSON.gz)
Salmonella enterica subsp. enterica serovar Typhimurium NCBITaxon:90371	—	>32.0 mg/L	—	Broth microdilution tetracycline MIC; modal MIC reported; interpreted using CLSI 2025 M100 S35 per the CDC/FDA AR Isolate Bank Panel 10 footnote.	0539	BioSample SAMN07688908	Evidence Page data (JSON.gz)

Resistance mechanisms

116 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_EFFLUX 69

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
AcrAB-TolC	ARO:3000384	not organism-specific	—	ARO:3000384 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
AdeABC	ARO:3000770	not organism-specific	—	ARO:3000770 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
AdeFGH	ARO:3000771	not organism-specific	—	ARO:3000771 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
AdeIJK	ARO:3000772	not organism-specific	—	ARO:3000772 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Corynebacterium striatum tetA	ARO:3004639	not organism-specific	—	ARO:3004639 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
EmrKY-TolC	ARO:3000373	not organism-specific	—	ARO:3000373 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance	ARO:3003374	not organism-specific	—	ARO:3003374 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Enterobacter cloacae rob	ARO:3004108	not organism-specific	—	ARO:3004108 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Escherichia coli AcrR with mutation associated with multidrug resistance	ARO:3003807	not organism-specific	—	ARO:3003807 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Escherichia coli MarR with mutation associated with multidrug resistance	ARO:3003378	not organism-specific	—	ARO:3003378 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Escherichia coli mdfA	ARO:3001328	not organism-specific	—	ARO:3001328 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Klebsiella pneumoniae KpnEF	ARO:3004585	not organism-specific	—	ARO:3004585 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
MexAB-OprM	ARO:3000386	not organism-specific	—	ARO:3000386 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
MexCD-OprJ	ARO:3000797	not organism-specific	—	ARO:3000797 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
MexGHI-OpmD	ARO:3000799	not organism-specific	—	ARO:3000799 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
MexJK-OprM	ARO:3003694	not organism-specific	—	ARO:3003694 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
MexPQ-OpmE	ARO:3003697	not organism-specific	—	ARO:3003697 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
MexVW-OprM	ARO:3003029	not organism-specific	—	ARO:3003029 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
MexXY-OprA	ARO:3003038	not organism-specific	—	ARO:3003038 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
MexXY-OprM	ARO:3003032	not organism-specific	—	ARO:3003032 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
MuxABC-OpmB	ARO:3004076	not organism-specific	—	ARO:3004076 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
SmeDEF	ARO:3003054	not organism-specific	—	ARO:3003054 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
aadT	ARO:3007669	not organism-specific	—	ARO:3007669 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
hp1165	ARO:3007061	not organism-specific	—	ARO:3007061 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
hp1181	ARO:3003964	not organism-specific	—	ARO:3003964 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
hp1184	ARO:3003965	not organism-specific	—	ARO:3003965 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
lmrP	ARO:3003969	not organism-specific	—	ARO:3003969 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
mdeA	ARO:3007011	not organism-specific	—	ARO:3007011 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
otr(B)	ARO:3002892	not organism-specific	—	ARO:3002892 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
otr(C)	ARO:3002894	not organism-specific	—	ARO:3002894 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tap	ARO:3000343	not organism-specific	—	ARO:3000343 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tcr3	ARO:3002893	not organism-specific	—	ARO:3002893 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(30)	ARO:3000561	not organism-specific	—	ARO:3000561 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(31)	ARO:3000476	not organism-specific	—	ARO:3000476 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(33)	ARO:3000478	not organism-specific	—	ARO:3000478 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(35)	ARO:3000481	not organism-specific	—	ARO:3000481 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(38)	ARO:3000565	not organism-specific	—	ARO:3000565 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(39)	ARO:3000566	not organism-specific	—	ARO:3000566 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(40)	ARO:3000567	not organism-specific	—	ARO:3000567 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(41)	ARO:3000569	not organism-specific	—	ARO:3000569 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(42)	ARO:3000572	not organism-specific	—	ARO:3000572 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(43)	ARO:3000573	not organism-specific	—	ARO:3000573 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(45)	ARO:3003196	not organism-specific	—	ARO:3003196 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(57)	ARO:3005006	not organism-specific	—	ARO:3005006 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(59)	ARO:3004441	not organism-specific	—	ARO:3004441 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(62)	ARO:3007492	not organism-specific	—	ARO:3007492 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(63)	ARO:3007493	not organism-specific	—	ARO:3007493 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(64)	ARO:3007494	not organism-specific	—	ARO:3007494 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(65)	ARO:3007838	not organism-specific	—	ARO:3007838 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(A)	ARO:3000165	not organism-specific	—	ARO:3000165 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(B)	ARO:3000166	not organism-specific	—	ARO:3000166 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(C)	ARO:3000167	not organism-specific	—	ARO:3000167 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(D)	ARO:3000168	not organism-specific	—	ARO:3000168 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(E)	ARO:3000173	not organism-specific	—	ARO:3000173 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(G)	ARO:3000174	not organism-specific	—	ARO:3000174 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(H)	ARO:3000175	not organism-specific	—	ARO:3000175 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(J)	ARO:3000177	not organism-specific	—	ARO:3000177 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(K)	ARO:3000178	not organism-specific	—	ARO:3000178 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(L)	ARO:3000179	not organism-specific	—	ARO:3000179 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(V)	ARO:3000181	not organism-specific	—	ARO:3000181 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(Y)	ARO:3000182	not organism-specific	—	ARO:3000182 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(Z)	ARO:3000183	not organism-specific	—	ARO:3000183 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tetA(58)	ARO:3003980	not organism-specific	—	ARO:3003980 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tetA(P)	ARO:3000180	not organism-specific	—	ARO:3000180 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tetAB(46)	ARO:3004031	not organism-specific	—	ARO:3004031 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tetAB(60)	ARO:3004034	not organism-specific	—	ARO:3004034 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tetB(58)	ARO:3003981	not organism-specific	—	ARO:3003981 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tetR(G)	ARO:3004653	not organism-specific	—	ARO:3004653 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
ykkCD	ARO:3003062	not organism-specific	—	ARO:3003062 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_PROTECTION 21

ANTIBIOTIC_TARGET_PROTECTION
Determinant	ARO ID	Organism	Gene families	Evidence
Streptomyces lividans otr(A)	ARO:3007127	not organism-specific	—	ARO:3007127 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
poxtA	ARO:3004470	not organism-specific	—	ARO:3004470 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
rpsJ	ARO:3003930	not organism-specific	—	ARO:3003930 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(32)	ARO:3000196	not organism-specific	—	ARO:3000196 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(36)	ARO:3000197	not organism-specific	—	ARO:3000197 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(44)	ARO:3000556	not organism-specific	—	ARO:3000556 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(61)	ARO:3004576	not organism-specific	—	ARO:3004576 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(M)	ARO:3000186	not organism-specific	—	ARO:3000186 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(O)	ARO:3000190	not organism-specific	—	ARO:3000190 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(O/32/O)	ARO:3007119	not organism-specific	—	ARO:3007119 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(O/M/O)	ARO:3007120	not organism-specific	—	ARO:3007120 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(O/W)	ARO:3007121	not organism-specific	—	ARO:3007121 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(O/W/32/O)	ARO:3007122	not organism-specific	—	ARO:3007122 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(O/W/O)	ARO:3007123	not organism-specific	—	ARO:3007123 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(Q)	ARO:3000191	not organism-specific	—	ARO:3000191 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(S)	ARO:3000192	not organism-specific	—	ARO:3000192 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(T)	ARO:3000193	not organism-specific	—	ARO:3000193 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(W)	ARO:3000194	not organism-specific	—	ARO:3000194 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(W/32/O)	ARO:3007124	not organism-specific	—	ARO:3007124 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(W/N/W)	ARO:3004442	not organism-specific	—	ARO:3004442 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tetB(P)	ARO:3000195	not organism-specific	—	ARO:3000195 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)

ANTIBIOTIC_INACTIVATION 18

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
tet(34)	ARO:3002870	not organism-specific	—	ARO:3002870 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(37)	ARO:3002871	not organism-specific	—	ARO:3002871 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(47)	ARO:3004613	not organism-specific	—	ARO:3004613 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(48)	ARO:3004581	not organism-specific	—	ARO:3004581 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(49)	ARO:3004582	not organism-specific	—	ARO:3004582 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(50)	ARO:3004584	not organism-specific	—	ARO:3004584 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(51)	ARO:3004586	not organism-specific	—	ARO:3004586 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(52)	ARO:3004587	not organism-specific	—	ARO:3004587 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(53)	ARO:3004589	not organism-specific	—	ARO:3004589 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(54)	ARO:3004590	not organism-specific	—	ARO:3004590 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(55)	ARO:3004591	not organism-specific	—	ARO:3004591 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(56)	ARO:3004603	not organism-specific	—	ARO:3004603 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(X)	ARO:3000205	not organism-specific	—	ARO:3000205 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(X1)	ARO:3005166	not organism-specific	—	ARO:3005166 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(X3)	ARO:3004719	not organism-specific	—	ARO:3004719 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(X4)	ARO:3004720	not organism-specific	—	ARO:3004720 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(X5)	ARO:3005057	not organism-specific	—	ARO:3005057 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
tet(X6)	ARO:3005056	not organism-specific	—	ARO:3005056 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_ALTERATION 4

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Cutibacterium acnes 16S rRNA mutation conferring resistance to tetracycline	ARO:3003499	not organism-specific	—	ARO:3003499 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to tetracycline	ARO:3003411	not organism-specific	—	ARO:3003411 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tetracycline	ARO:3003410	not organism-specific	—	ARO:3003410 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Helicobacter pylori 16S rRNA mutation conferring resistance to tetracycline	ARO:3003510	not organism-specific	—	ARO:3003510 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)

REDUCED_PERMEABILITY 2

REDUCED_PERMEABILITY
Determinant	ARO ID	Organism	Gene families	Evidence
Neisseria gonorrhoeae porin PIB (por)	ARO:3000464	not organism-specific	—	ARO:3000464 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)
Serratia marcescens Omp1	ARO:3004128	not organism-specific	—	ARO:3004128 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_REPLACEMENT 1

ANTIBIOTIC_TARGET_REPLACEMENT
Determinant	ARO ID	Organism	Gene families	Evidence
dfrL	ARO:3007456	not organism-specific	—	ARO:3007456 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)

UNKNOWN 1

UNKNOWN
Determinant	ARO ID	Organism	Gene families	Evidence
PvrR	ARO:3003688	not organism-specific	—	ARO:3003688 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000051 (tetracycline); database assertion, not a primary citation.)

Record-level evidence

PMID:11163189 (Primary exact-tetracycline 30S ribosome structural mechanism study.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
REVIEWED 2026-09-02 · codex · LLM-assisted
Verified exact ChEBI/CARD identity, structure, roles, class, and provenance of 116 retained CARD resistance assertions; curator-confirmed protein synthesis inhibition and added the directly bound 30S target.
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories
CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted
Added one stable-URL CDC/FDA AR Isolate Bank tetracycline-resistant Escherichia coli isolate MIC observation.
CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted
Added one stable-URL CDC/FDA AR Isolate Bank tetracycline-resistant Klebsiella pneumoniae isolate MIC observation.
CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted
Added one stable-URL CDC/FDA AR Isolate Bank tetracycline-resistant Acinetobacter baumannii isolate MIC observation.
CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted
Corrected the CDC/FDA AR Isolate Bank 0349 breakpoint context from CLSI 2024 M100 S34 to CLSI 2025 M100 S35.
CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted
Added one stable-URL CDC/FDA AR Isolate Bank tetracycline-resistant Escherichia coli MIC observation from isolate 0346.
CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted
Added one stable-URL CDC/FDA AR Isolate Bank tetracycline-resistant Escherichia coli isolate MIC observation for AR-1305.
CURATED_RESISTANT_TAXA 2026-09-12 · codex · LLM-assisted
Added 7 stable-URL CDC/FDA AR Isolate Bank tetracycline-resistant Multi-Mechanism panel MIC observations for AR-1149, AR-1151, AR-1152, AR-1153, AR-1160, AR-1162, and AR-1163.
CURATED_RESISTANT_TAXA 2026-09-13 · codex · LLM-assisted
Added two stable-URL CDC/FDA AR Isolate Bank Panel 1125 tetracycline-resistant Staphylococcus aureus activity observations for AR-0701 and AR-0702.
CURATED_RESISTANT_TAXA 2026-09-13 · codex · LLM-assisted
Added two stable-URL CDC/FDA AR Isolate Bank Panel 10 tetracycline-resistant Neisseria gonorrhoeae MIC observations for AR-1280 and AR-1281.
CURATED_RESISTANT_TAXA 2026-09-17 · codex · LLM-assisted
Added one stable-URL CDC/FDA AR Isolate Bank Panel 10 tetracycline-resistant Escherichia coli MIC observation for AR-0495.
CURATED_RESISTANT_TAXA 2026-09-19 · codex · LLM-assisted
Added one stable-URL CDC/FDA AR Isolate Bank Panel 1227 tetracycline-resistant Acinetobacter baumannii MIC observation for AR-0078; preserved source Pus, BioSample SAMN04014919, Study ID CarbaNP-47, and MLST ST229(Pasteur)/ST203(Oxford) in evidence notes.
CURATED_RESISTANT_TAXA 2026-09-19 · codex · LLM-assisted
Added one stable-URL CDC/FDA AR Isolate Bank Panel 1227 tetracycline-resistant Acinetobacter baumannii MIC observation for AR-0083; preserved source Unknown, BioSample SAMN04014924, Study ID CarbaNP-52, and MLST ST1(Pasteur)/ST231/1604(Oxford) in evidence notes.
CURATED_RESISTANT_TAXA 2026-09-21 · codex · LLM-assisted
Added one stable-URL CDC/FDA AR Isolate Bank Panel 10 tetracycline-resistant Salmonella Typhimurium MIC observation for AR-0539; preserved source Stool, BioSample SAMN07688908, and Study ID NEW-23 in evidence notes.
STRUCTURED_ACTIVITY_BIOSAMPLE_ACCESSIONS 2026-09-26 · codex · LLM-assisted
Structured BioSample accessions on 20 activity_spectrum observation(s) where evidence notes already named exactly one accession.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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