tetroxoprim

CHEBI:135420 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

Tetroxoprim is a trimethoprim derivative that inhibits bacterial dihydrofolate reductase. — PMID:3043259

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

diaminopyrimidine antibioticARO:3000171

Strictly broader compounds or drug classes this molecule belongs to.

diaminopyrimidine antibiotic ARO:3000171

Chemical structure

Computed structure properties
Molecular formula	C16H22N4O4
Charge	0
Average mass	334.376 Da
Monoisotopic mass	334.16411 Da
Source	ChEBI
InChIKey	WSWJIZXMAUYHOE-UHFFFAOYSA-N

SMILES

COCCOc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC

InChI

InChI=1S/C16H22N4O4/c1-21-4-5-24-14-12(22-2)7-10(8-13(14)23-3)6-11-9-19-16(18)20-15(11)17/h7-9H,4-6H2,1-3H3,(H4,17,18,19,20)

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3000284`	tetroxoprim	`antibioticmech:aro-b7e441c49c`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive dihydrofolate reductase PROTEIN DIRECT_BINDING_TARGET

ARO:3000745

CARD/ARO database assertion; target organism, strain, and assay are not specified. Dihydrofolate reductase is asserted as the inhibited enzyme. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000745 (CARD/ARO asserts targeted_by_antibiotic ARO:3000284 (tetroxoprim); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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