tetroxoprim
CHEBI:135420
·resolve ·ANTIBACTERIAL
·EXACT
SEEDED
Tetroxoprim is a trimethoprim derivative that inhibits bacterial dihydrofolate reductase. — PMID:3043259
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
diaminopyrimidine antibioticARO:3000171
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C16H22N4O4 |
|---|
| Charge | 0 |
|---|
| Average mass | 334.376 Da |
|---|
| Monoisotopic mass | 334.16411 Da |
|---|
| Source | ChEBI |
|---|
| InChIKey | WSWJIZXMAUYHOE-UHFFFAOYSA-N |
|---|
SMILES
COCCOc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC
InChI
InChI=1S/C16H22N4O4/c1-21-4-5-24-14-12(22-2)7-10(8-13(14)23-3)6-11-9-19-16(18)20-15(11)17/h7-9H,4-6H2,1-3H3,(H4,17,18,19,20)
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3000284 |
tetroxoprim |
antibioticmech:aro-b7e441c49c |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
antibiotic sensitive dihydrofolate reductase PROTEIN DIRECT_BINDING_TARGET
ARO:3000745
CARD/ARO database assertion; target organism, strain, and assay are not specified. Dihydrofolate reductase is asserted as the inhibited enzyme. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000745 (CARD/ARO asserts targeted_by_antibiotic ARO:3000284 (tetroxoprim); database assertion, not a primary citation.)
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.