ticarcillin

CHEBI:9587 ·resolve ·ANTIBACTERIAL ·EXACT SEEDED

A penicillin compound having a 6β-[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino side-group. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

penicillin beta-lactamARO:3000008

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:17334 CHEBI:17334
CHEBI:88187 CHEBI:88187
ARO:3000008 ARO:3000008

Chemical structure

Computed structure properties
Molecular formula	C15H16N2O6S2
Charge	0
Average mass	384.435 Da
Monoisotopic mass	384.04498 Da
Source	ChEBI
InChIKey	OHKOGUYZJXTSFX-KZFFXBSXSA-N

SMILES

[H][C@](C(=O)O)(C(=O)N[C@@H]1C(=O)N2[C@@H](C(=O)O)C(C)(C)S[C@]12[H])c1ccsc1

InChI

InChI=1S/C15H16N2O6S2/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23)/t7-,8-,9+,12-/m1/s1

Also called

ticarcilina (INN)— chebi
ticarcilline (INN)— chebi
ticarcillinum (INN)— chebi
6β-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-2,2-dimethylpenam-3α-carboxylic acid (EXACT_SYNONYM)— chebi
(2S,5R,6R)-6-{[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (EXACT_SYNONYM)— chebi
α-carboxy-3-thienylmethylpenicillin (EXACT_SYNONYM)— chebi
Ticarcilina (EXACT_SYNONYM)— aro
Ticarcilline (EXACT_SYNONYM)— aro
Ticarcillinum (EXACT_SYNONYM)— aro

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3003832
cas:34787-01-4
drugbank:DB01607
drugcentral:2656
kegg.compound:C07139
kegg.drug:D08593
patent:BE646991
patent:US3282926
reaxys:6009447
wikipedia.en:Ticarcillin
chembl:CHEMBL1449
pubchem.compound:36921

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281
CHEBI:36047 CHEBI:36047

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3003832`	ticarcillin	`antibioticmech:aro-2ab5f0633c`	2026-08-30
CHEBI	`CHEBI:9587`	ticarcillin	`antibioticmech:chebi-3a2e3987ad`	2026-08-30

Resistance mechanisms

15 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_INACTIVATION 13

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
ACI-1	ARO:3004359	not organism-specific	—	ARO:3004359 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
CDA-1	ARO:3007650	not organism-specific	—	ARO:3007650 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
LAP-1	ARO:3004825	not organism-specific	—	ARO:3004825 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
LAP-2	ARO:3004826	not organism-specific	—	ARO:3004826 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
MAB	ARO:3007180	not organism-specific	—	ARO:3007180 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
MUS-1	ARO:3000843	not organism-specific	—	ARO:3000843 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
MUS-2	ARO:3003842	not organism-specific	—	ARO:3003842 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
NDM-4	ARO:3002355	not organism-specific	—	ARO:3002355 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
SCO-1	ARO:3004856	not organism-specific	—	ARO:3004856 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
SED-1	ARO:3003561	not organism-specific	—	ARO:3003561 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
TUS-1	ARO:3000844	not organism-specific	—	ARO:3000844 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
blaC	ARO:3007182	not organism-specific	—	ARO:3007182 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
y56 beta-lactamase	ARO:3003558	not organism-specific	—	ARO:3003558 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)

ANTIBIOTIC_EFFLUX 2

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
AdeIJK	ARO:3000772	not organism-specific	—	ARO:3000772 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)
Klebsiella pneumoniae KpnGH-TolC	ARO:3004598	not organism-specific	—	ARO:3004598 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3003832 (ticarcillin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.