tuberactinomycin

antibioticmech:aro-4c6e0c1ff0 ·ANTIBACTERIAL ·MINTED SEEDED

Tuberactinomycins are a family of cyclic peptide antibiotics that are important in the treatment of tuberculosis. Tuberactinomycins contain nonproteinogenic amino acids and inhibit group I self-splicing RNA to disrupt prokaryotic protein synthesis. — PMID:7509881

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

nonribosomal peptide antibioticsARO:3009657

Strictly broader compounds or drug classes this molecule belongs to.

nonribosomal peptide antibiotics ARO:3009657

Chemical structure

Computed structure properties
Molecular formula	C25H43N13O11
Charge	0
Average mass	701.7 Da
Monoisotopic mass	701.32049924 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	JCTPGOAHEVLZAB-KIXAZQDESA-N

SMILES

C1[C@@H](NC(=N[C@H]1O)N)C2C(=O)NCC(C(=O)NC(C(=O)NC(C(=O)N/C(=C\NC(=O)N)/C(=O)N2)CO)CO)NC(=O)CC(C(CCN)O)N

InChI

InChI=1S/C25H43N13O11/c26-2-1-15(41)9(27)3-16(42)32-11-5-30-23(48)18(10-4-17(43)37-24(28)36-10)38-20(45)12(6-31-25(29)49)33-21(46)13(7-39)35-22(47)14(8-40)34-19(11)44/h6,9-11,13-15,17-18,39-41,43H,1-5,7-8,26-27H2,(H,30,48)(H,32,42)(H,33,46)(H,34,44)(H,35,47)(H,38,45)(H3,28,36,37)(H3,29,31,49)/b12-6-/t9?,10-,11?,13?,14?,15?,17+,18?/m1/s1

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

tuberactinomycinARO:3000490
pubchem.compound:24847446

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3000490`	tuberactinomycin	`antibioticmech:aro-4c6e0c1ff0`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

ribosomal complex PROTEIN_COMPLEX DIRECT_BINDING_TARGET

ARO:3000729

CARD/ARO database assertion; target organism, strain, and assay are not specified. ARO asserts stabilization of the ribosomal complex by antibiotics. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000729 (CARD/ARO asserts targeted_by_antibiotic ARO:3000490 (tuberactinomycin); database assertion, not a primary citation.)

RNA guanosine binding site NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000739

CARD/ARO database assertion; target organism, strain, and assay are not specified. ARO asserts competition at the RNA guanosine-binding site. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000739 (CARD/ARO asserts targeted_by_antibiotic ARO:3000490 (tuberactinomycin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

Explore across X-Mech: MediaIngredientMech (tuberactinomycin) · CultureMech · NaturalProductMech · PathwayMech · TraitMech