virginiamycin M1

antibioticmech:aro-88dda0e2d9 ·ANTIBACTERIAL ·MINTED SEEDED

Virginiamycin M1 is a streptogramin A antibiotic. — PMID:15700955

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

streptogramin antibioticARO:0000026

Strictly broader compounds or drug classes this molecule belongs to.

streptogramin antibiotic ARO:0000026

Chemical structure

Computed structure properties
Molecular formula	C28H35N3O7
Charge	0
Average mass	525.6 Da
Monoisotopic mass	525.24750046 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	DAIKHDNSXMZDCU-ZFPSYPIXSA-N

SMILES

C[C@@H]1/C=C\C(=O)NC/C=C\C(=C/[C@H](CC(=O)CC2=NC(=CO2)C(=O)N3CCC=C3C(=O)O[C@H]1C(C)C)O)\C

InChI

InChI=1S/C28H35N3O7/c1-17(2)26-19(4)9-10-24(34)29-11-5-7-18(3)13-20(32)14-21(33)15-25-30-22(16-37-25)27(35)31-12-6-8-23(31)28(36)38-26/h5,7-10,13,16-17,19-20,26,32H,6,11-12,14-15H2,1-4H3,(H,29,34)/b7-5-,10-9-,18-13-/t19-,20-,26+/m1/s1

Also called

Pristinamycin IIA (EXACT_SYNONYM)— aro
Pristinamycin IIB (EXACT_SYNONYM)— aro
Virginiamycin IIB (EXACT_SYNONYM)— aro

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3000669`	virginiamycin M1	`antibioticmech:aro-88dda0e2d9`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive peptidyl transferase (23S rRNA) NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000754

CARD/ARO database assertion; target organism, strain, and assay are not specified. 23S rRNA peptidyl-transferase center is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000754 (CARD/ARO asserts targeted_by_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)

Resistance mechanisms

50 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 26

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Erm(33)	ARO:3000599	not organism-specific	—	ARO:3000599 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
Erm(34)	ARO:3000600	not organism-specific	—	ARO:3000600 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
Erm(35)	ARO:3000604	not organism-specific	—	ARO:3000604 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
Erm(36)	ARO:3000605	not organism-specific	—	ARO:3000605 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
Erm(37)	ARO:3000392	not organism-specific	—	ARO:3000392 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
Erm(38)	ARO:3000601	not organism-specific	—	ARO:3000601 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
Erm(39)	ARO:3000602	not organism-specific	—	ARO:3000602 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
Erm(41)	ARO:3000603	not organism-specific	—	ARO:3000603 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmA	ARO:3000347	not organism-specific	—	ARO:3000347 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmB	ARO:3000375	not organism-specific	—	ARO:3000375 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmC	ARO:3000250	not organism-specific	—	ARO:3000250 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmD	ARO:3000495	not organism-specific	—	ARO:3000495 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmE	ARO:3000326	not organism-specific	—	ARO:3000326 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmF	ARO:3000498	not organism-specific	—	ARO:3000498 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmG	ARO:3000522	not organism-specific	—	ARO:3000522 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmN	ARO:3000592	not organism-specific	—	ARO:3000592 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmQ	ARO:3000593	not organism-specific	—	ARO:3000593 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmR	ARO:3000594	not organism-specific	—	ARO:3000594 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmT	ARO:3000595	not organism-specific	—	ARO:3000595 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
ErmX	ARO:3000596	not organism-specific	—	ARO:3000596 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
Streptococcus pneumoniae 23S rRNA mutation conferring resistance to macrolides and streptogramins antibiotics	ARO:3004181	not organism-specific	—	ARO:3004181 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
cfrA	ARO:3003441	not organism-specific	—	ARO:3003441 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
cipA	ARO:3003907	not organism-specific	—	ARO:3003907 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
clbA	ARO:3002814	not organism-specific	—	ARO:3002814 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
clbB	ARO:3002815	not organism-specific	—	ARO:3002815 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
clbC	ARO:3002816	not organism-specific	—	ARO:3002816 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_PROTECTION 15

ANTIBIOTIC_TARGET_PROTECTION
Determinant	ARO ID	Organism	Gene families	Evidence
Clostridioides difficile cplR	ARO:3007637	not organism-specific	—	ARO:3007637 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
Clostridium perfringes cplR	ARO:3007644	not organism-specific	—	ARO:3007644 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
Neobacillus vireti vmlR2	ARO:3007646	not organism-specific	—	ARO:3007646 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
lsaD	ARO:3005121	not organism-specific	—	ARO:3005121 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
salA	ARO:3003749	not organism-specific	—	ARO:3003749 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
salB	ARO:3007026	not organism-specific	—	ARO:3007026 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
salC	ARO:3007027	not organism-specific	—	ARO:3007027 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
salD	ARO:3007028	not organism-specific	—	ARO:3007028 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vga(E) Staphylococcus cohnii	ARO:3004715	not organism-specific	—	ARO:3004715 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vgaA	ARO:3002829	not organism-specific	—	ARO:3002829 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vgaALC	ARO:3002830	not organism-specific	—	ARO:3002830 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vgaB	ARO:3000118	not organism-specific	—	ARO:3000118 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vgaC	ARO:3002831	not organism-specific	—	ARO:3002831 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vgaE	ARO:3002833	not organism-specific	—	ARO:3002833 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vmlR	ARO:3004476	not organism-specific	—	ARO:3004476 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)

ANTIBIOTIC_INACTIVATION 9

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
VatI	ARO:3003987	not organism-specific	—	ARO:3003987 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
streptogramin vat acetyltransferase	ARO:3000453	not organism-specific	—	ARO:3000453 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vatA	ARO:3002840	not organism-specific	—	ARO:3002840 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vatB	ARO:3002841	not organism-specific	—	ARO:3002841 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vatC	ARO:3002842	not organism-specific	—	ARO:3002842 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vatD	ARO:3002843	not organism-specific	—	ARO:3002843 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vatE	ARO:3002844	not organism-specific	—	ARO:3002844 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vatF	ARO:3003744	not organism-specific	—	ARO:3003744 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)
vatH	ARO:3002845	not organism-specific	—	ARO:3002845 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000669 (virginiamycin M1); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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