virginiamycin S2
antibioticmech:aro-2a1d8b8631
·ANTIBACTERIAL
·MINTED
SEEDED
Virginiamycin S2 is a streptogramin B antibiotic. — PMID:15700955
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
streptogramin antibioticARO:0000026
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C42H49N7O10 |
|---|
| Charge | 0 |
|---|
| Average mass | 811.9 Da |
|---|
| Monoisotopic mass | 811.35409079 Da |
|---|
| Source | PubChem · retrieved 2026-08-29 |
|---|
| InChIKey | LRSRCZBNIGNEHL-NTXCPLLSSA-N |
|---|
SMILES
CC[C@@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N3CC[C@@H](C[C@H]3C(=O)N[C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)O)CC6=CC=CC=C6
InChI
InChI=1S/C42H49N7O10/c1-3-28-40(56)48-20-11-16-30(48)36(52)45-29(22-25-12-6-4-7-13-25)41(57)49-21-18-27(50)23-31(49)37(53)47-34(26-14-8-5-9-15-26)42(58)59-24(2)33(38(54)44-28)46-39(55)35-32(51)17-10-19-43-35/h4-10,12-15,17,19,24,27-31,33-34,50-51H,3,11,16,18,20-23H2,1-2H3,(H,44,54)(H,45,52)(H,46,55)(H,47,53)/t24-,27+,28-,29+,30+,31+,33+,34+/m1/s1
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3000677 |
virginiamycin S2 |
antibioticmech:aro-2a1d8b8631 |
2026-08-30 |
Molecular targets
The molecular entity or process this compound acts on. Each target
carries evidence — this is a mechanistic claim, not a classification.
antibiotic sensitive peptidyl transferase (23S rRNA) NUCLEIC_ACID DIRECT_BINDING_TARGET
ARO:3000754
CARD/ARO database assertion; target organism, strain, and assay are not specified. 23S rRNA peptidyl-transferase center is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).
- ARO:3000754 (CARD/ARO asserts targeted_by_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
Resistance mechanisms
24 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 20
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Erm(33) |
ARO:3000599 |
not organism-specific |
— |
- ARO:3000599 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| Erm(34) |
ARO:3000600 |
not organism-specific |
— |
- ARO:3000600 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| Erm(35) |
ARO:3000604 |
not organism-specific |
— |
- ARO:3000604 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| Erm(36) |
ARO:3000605 |
not organism-specific |
— |
- ARO:3000605 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| Erm(37) |
ARO:3000392 |
not organism-specific |
— |
- ARO:3000392 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| Erm(38) |
ARO:3000601 |
not organism-specific |
— |
- ARO:3000601 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| Erm(39) |
ARO:3000602 |
not organism-specific |
— |
- ARO:3000602 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| Erm(41) |
ARO:3000603 |
not organism-specific |
— |
- ARO:3000603 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmA |
ARO:3000347 |
not organism-specific |
— |
- ARO:3000347 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmB |
ARO:3000375 |
not organism-specific |
— |
- ARO:3000375 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmC |
ARO:3000250 |
not organism-specific |
— |
- ARO:3000250 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmD |
ARO:3000495 |
not organism-specific |
— |
- ARO:3000495 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmE |
ARO:3000326 |
not organism-specific |
— |
- ARO:3000326 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmF |
ARO:3000498 |
not organism-specific |
— |
- ARO:3000498 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmG |
ARO:3000522 |
not organism-specific |
— |
- ARO:3000522 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmN |
ARO:3000592 |
not organism-specific |
— |
- ARO:3000592 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmQ |
ARO:3000593 |
not organism-specific |
— |
- ARO:3000593 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmR |
ARO:3000594 |
not organism-specific |
— |
- ARO:3000594 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmT |
ARO:3000595 |
not organism-specific |
— |
- ARO:3000595 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| ErmX |
ARO:3000596 |
not organism-specific |
— |
- ARO:3000596 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
ANTIBIOTIC_INACTIVATION 3
ANTIBIOTIC_INACTIVATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| vgbA |
ARO:3001307 |
not organism-specific |
— |
- ARO:3001307 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| vgbB |
ARO:3001308 |
not organism-specific |
— |
- ARO:3001308 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
| vgbC |
ARO:3003990 |
not organism-specific |
— |
- ARO:3003990 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
ANTIBIOTIC_TARGET_PROTECTION 1
ANTIBIOTIC_TARGET_PROTECTION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| vmlR |
ARO:3004476 |
not organism-specific |
— |
- ARO:3004476 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000677 (virginiamycin S2); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.