zoliflodacin
antibioticmech:aro-88c211f0f6
·ANTIBACTERIAL
·MINTED
SEEDED
Experimental antibiotic in phase two trial for Neisseria gonorrhoeae treatment. — PMID:31730160
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
zoliflodacin-like antibioticARO:3007160
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C22H22FN5O7 |
|---|
| Charge | 0 |
|---|
| Average mass | 487.4 Da |
|---|
| Monoisotopic mass | 487.15032622 Da |
|---|
| Source | PubChem · retrieved 2026-08-29 |
|---|
| InChIKey | ZSWMIFNWDQEXDT-ZESJGQACSA-N |
|---|
SMILES
C[C@@H]1CN2[C@H]([C@@H](O1)C)C3(CC4=CC5=C(C(=C42)F)ON=C5N6[C@H](COC6=O)C)C(=O)NC(=O)NC3=O
InChI
InChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3004858 |
zoliflodacin |
antibioticmech:aro-88c211f0f6 |
2026-08-30 |
Mechanism summary
- Clinical status
- APPROVED
Resistance mechanisms
1 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 1
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Neisseria gonorrhoeae gyrB conferring resistance to zoliflodacin |
ARO:3004859 |
not organism-specific |
— |
- ARO:3004859 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004858 (zoliflodacin); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.