(16R,19E)-isositsirikine

CHEBI:70508 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

An indole alkaloid with formula C21H26N2O3. It is a natural product found in several plant species including Alstonia spatulata and Catharanthus roseus. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:15734
Label unavailable CHEBI:25248
Label unavailable CHEBI:38163
Label unavailable CHEBI:38958

Chemical structure

Computed structure properties
Molecular formula	C21H26N2O3
Charge	0
Average mass	354.45 Da
Monoisotopic mass	354.19434 Da
Source	ChEBI
InChIKey	RGXKJLTVROJBKZ-LZNZQLKFSA-N

SMILES

[H][C@]1([C@H](CO)C(=O)OC)C[C@@]2([H])c3nc4ccccc4c3CCN2C/C1=C/C

InChI

InChI=1S/C21H26N2O3/c1-3-13-11-23-9-8-15-14-6-4-5-7-18(14)22-20(15)19(23)10-16(13)17(12-24)21(25)26-2/h3-7,16-17,19,22,24H,8-12H2,1-2H3/b13-3-/t16-,17-,19-/m0/s1

Also called

methyl (2R)-2-[(2R,3E,12bS)-3-ethylidene-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-hydroxypropanoate (EXACT_SYNONYM)— chebi
(16R)-E-isositsirikine (EXACT_SYNONYM)— chebi
16(R)-19,20-E-isositsirikine (EXACT_SYNONYM)— chebi
16(R)-E-isositsirikine (EXACT_SYNONYM)— chebi
16R,19E-isositsirikine (EXACT_SYNONYM)— chebi
16R-19,20-E-isositsirikine (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antifungal agent CHEBI:35718

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:70508`	(16R,19E)-isositsirikine	`antibioticmech:chebi-5bfb8ce56a`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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