AntibioticMech

5-Fluorouracil

CHEBI:46345 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

5-Fluorouracil (5FU) is an antimetabolite typically used as a cancer treatment and is cytotoxic. It is a pyrimidine analogue inhibits thymidylate synthase which halts the DNA synthesis. Its cytotoxic effects on eukaryotic cells have also allowed the drug to be explored for fungal infection treatment as well. — PMID:20823283

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

pyrimidine antifungalARO:3007560

Strictly broader compounds or drug classes this molecule belongs to.

Chemical structure

Computed structure properties
Molecular formulaC4H3FN2O2
Charge0
Average mass130.078 Da
Monoisotopic mass130.01786 Da
SourceChEBI
InChIKeyGHASVSINZRGABV-UHFFFAOYSA-N

SMILES

O=c1ncc(F)c(=O)n1

InChI

InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

Cross-references

Equivalent identifiers for this same structure in other resources.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
SourceNative IDLabelMinted CURIEVersion
ARO ARO:3009138 5-Fluorouracil antibioticmech:aro-48b83a8ef7 2026-08-30

Mechanism summary

Clinical status
APPROVED

Curation history

  1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Seeded from data/raw/ inventories (ARO)

  2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.