AntibioticMech

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anidulafungin

CHEBI:55346 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

echinocandin antibioticARO:3007496

Strictly broader compounds or drug classes this molecule belongs to.

Chemical structure

Computed structure properties
Molecular formulaC58H73N7O17
Charge0
Average mass1140.254 Da
Monoisotopic mass1139.50629 Da
SourceChEBI
InChIKeyJHVAMHSQVVQIOT-MFAJLEFUSA-N

SMILES

[H][C@@]1([C@@H](C)O)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)c2ccc(-c3ccc(-c4ccc(OCCCCC)cc4)cc3)cc2)C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C1=O

InChI

InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42-,43+,44-,45-,46-,47-,48-,49-,50-,54+/m0/s1

Also called

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
SourceNative IDLabelMinted CURIEVersion
ARO ARO:3007503 anidulafungin antibioticmech:aro-f30e065178 2026-08-30
CHEBI CHEBI:55346 anidulafungin antibioticmech:chebi-4eac20bab5 2026-08-30

Mechanism summary

Mode of action
CELL_WALL_SYNTHESIS_INHIBITION microbial target — Assigned from ChEBI role CHEBI:230471 (EC 2.4.1.34 (1,3-β-glucan synthase) inhibitor). ChEBI asserts the role on the compound. The role names a target specific to the microbe or virus — see mode_of_action_target_scope. Not a curator's mechanistic review.
Clinical status
APPROVED

Resistance mechanisms

21 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 12
ANTIBIOTIC_TARGET_ALTERATION
DeterminantARO IDOrganismGene familiesEvidence
Candida albicans FKS1 with mutations conferring resistance to anidulafungin ARO:3009417 not organism-specific —
  • ARO:3009417 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Candida auris FKS1 beta-1,3-glucan synthase with mutations conferring resistance to anidulafungin ARO:3009419 not organism-specific —
  • ARO:3009419 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Candida dubliniensis FKS1 beta-1,3-glucan synthase with mutations conferring resistance to anidulafungin ARO:3009560 not organism-specific —
  • ARO:3009560 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Candida glabrata FKS1 with mutations conferring resistance to anidulafungin ARO:3009233 not organism-specific —
  • ARO:3009233 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Candida glabrata FKS2 with mutations conferring resistance to anidulafungin ARO:3009207 not organism-specific —
  • ARO:3009207 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Candida metapsilosis FKS1 beta-1,3-glucan with mutations conferring resistance to anidulafungin ARO:3009594 not organism-specific —
  • ARO:3009594 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Candida parapsilosis Erg3 with mutations conferring resistance to anidulafungin ARO:3009247 not organism-specific —
  • ARO:3009247 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Candida parapsilosis FSK1 beta-1,3-D-glucan synthase with mutations associated with resistance to anidulafungin ARO:3009597 not organism-specific —
  • ARO:3009597 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Candida tropicalis FKS1 beta-1,3-glucan synthase with mutations conferring resistance to anidulafungin ARO:3009600 not organism-specific —
  • ARO:3009600 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Kluyveromyces marxianus FKS1 beta-1,3-glucan synthase with mutations conferring resistance to anidulafungin ARO:3009604 not organism-specific —
  • ARO:3009604 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Pichia kudriavzevii Fks1 beta-1,3-glucan synthase with mutations associated with resistance to anidulafungin ARO:3009287 not organism-specific —
  • ARO:3009287 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
Saccharomyces cerevisiae FKS1 beta-1,3-D-glucan synthase with mutations conferring resistance to anidulafungin ARO:3009423 not organism-specific —
  • ARO:3009423 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007503 (anidulafungin); database assertion, not a primary citation.)
UNKNOWN 9
UNKNOWN
DeterminantARO IDOrganismGene familiesEvidence
FKS1(F641S) (amino acid mutation) [Not assayed] associated with resistance to anidulafungin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review balashov-2006-reference-context: The strain label denotes a parent background, not an individually resolved resistant derivative. Imported protein/strain identifiers are reference-only. AF027295 / AAC49870.1 maps explicitly to UniProtKB:O13383 (CaFKS1; CAI4 reference), not an experimental allele. Source notation remains unnormalized; aggregated zygosity and grouped MICs must not be assigned to individual isolates. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:A0A1D8PCT0.		 — Candida albicans NCBITaxon:5476
strain M70
PHIPO:0000586		 —
  • PMID:16723566 (PHI-base primary-literature antimicrobial interaction PHIG:1428; joined to this record by exact ChEBI identifier.)
  • DOI:10.1128/aac.01653-05 (Identifier-scope review: Results: resistant derivatives and cross-resistance, Table 3, Declared FKS1 reference accessions, UniProtKB release 2026_03: O13383 entry 50, sequence version 1; A0A1D8PCT0 entry 36, sequence version 1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
FKS1(L644F S645C) (amino acid mutation) [Not assayed] associated with resistance to anidulafungin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review balashov-2006-reference-context: The strain label denotes a parent background, not an individually resolved resistant derivative. Imported protein/strain identifiers are reference-only. AF027295 / AAC49870.1 maps explicitly to UniProtKB:O13383 (CaFKS1; CAI4 reference), not an experimental allele. Source notation remains unnormalized; aggregated zygosity and grouped MICs must not be assigned to individual isolates. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:A0A1D8PCT0.		 — Candida albicans NCBITaxon:5476
strain M70
PHIPO:0000586		 —
  • PMID:16723566 (PHI-base primary-literature antimicrobial interaction PHIG:1428; joined to this record by exact ChEBI identifier.)
  • DOI:10.1128/aac.01653-05 (Identifier-scope review: Results: resistant derivatives and cross-resistance, Table 3, Declared FKS1 reference accessions, UniProtKB release 2026_03: O13383 entry 50, sequence version 1; A0A1D8PCT0 entry 36, sequence version 1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
FKS1(P647A) (amino acid mutation) [Not assayed] associated with resistance to anidulafungin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review garcia-effron-2008-subject-context: BY4742-P649A is the derivative label printed in Table 1, whereas Results and the imported alteration use P647A. This discrepancy is preserved, not normalized. UniProtKB:P38631 / AAC48981.1 and the retained gene_id ground the reference FKS1 locus, not a verified derivative sequence. Reference strain identity, native Candida observations, whole-cell MICs and enzyme inhibition remain distinct. Original source background label: BY4742. Reference-only source identifiers: strain_taxon_id=NCBITaxon:559292; protein_accession=UniProtKB:P38631.		 — Saccharomyces cerevisiae NCBITaxon:4932
strain BY4742-P649A YLR342W_mRNA
PHIPO:0000586		 —
  • PMID:18443110 (PHI-base primary-literature antimicrobial interaction PHIG:2386; joined to this record by exact ChEBI identifier.)
  • DOI:10.1128/aac.00262-08 (Identifier-scope review: Table 1: parent and derivative rows, Results: Saccharomyces comparison, Figure 1: AAC48981 reference, UniProtKB release 2026_03: P38631 entry 209, sequence version 2; EnsemblFungi cross-reference. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
FKS1(S645F) (amino acid mutation) [Not assayed] associated with resistance to anidulafungin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review balashov-2006-reference-context: The strain label denotes a parent background, not an individually resolved resistant derivative. Imported protein/strain identifiers are reference-only. AF027295 / AAC49870.1 maps explicitly to UniProtKB:O13383 (CaFKS1; CAI4 reference), not an experimental allele. Source notation remains unnormalized; aggregated zygosity and grouped MICs must not be assigned to individual isolates. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:A0A1D8PCT0.		 — Candida albicans NCBITaxon:5476
strain M70
PHIPO:0000586		 —
  • PMID:16723566 (PHI-base primary-literature antimicrobial interaction PHIG:1428; joined to this record by exact ChEBI identifier.)
  • DOI:10.1128/aac.01653-05 (Identifier-scope review: Results: resistant derivatives and cross-resistance, Table 3, Declared FKS1 reference accessions, UniProtKB release 2026_03: O13383 entry 50, sequence version 1; A0A1D8PCT0 entry 36, sequence version 1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
FKS1(S645F) (amino acid mutation) [Not assayed] associated with resistance to anidulafungin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review balashov-2006-reference-context: The strain label denotes a parent background, not an individually resolved resistant derivative. Imported protein/strain identifiers are reference-only. AF027295 / AAC49870.1 maps explicitly to UniProtKB:O13383 (CaFKS1; CAI4 reference), not an experimental allele. Source notation remains unnormalized; aggregated zygosity and grouped MICs must not be assigned to individual isolates. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:A0A1D8PCT0.		 — Candida albicans NCBITaxon:5476
strain SC5314
PHIPO:0000586		 —
  • PMID:16723566 (PHI-base primary-literature antimicrobial interaction PHIG:1428; joined to this record by exact ChEBI identifier.)
  • DOI:10.1128/aac.01653-05 (Identifier-scope review: Results: resistant derivatives and cross-resistance, Table 3, Declared FKS1 reference accessions, UniProtKB release 2026_03: O13383 entry 50, sequence version 1; A0A1D8PCT0 entry 36, sequence version 1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
FKS1(S645P) (amino acid mutation) [Not assayed] associated with resistance to anidulafungin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review balashov-2006-reference-context: The strain label denotes a parent background, not an individually resolved resistant derivative. Imported protein/strain identifiers are reference-only. AF027295 / AAC49870.1 maps explicitly to UniProtKB:O13383 (CaFKS1; CAI4 reference), not an experimental allele. Source notation remains unnormalized; aggregated zygosity and grouped MICs must not be assigned to individual isolates. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:A0A1D8PCT0.		 — Candida albicans NCBITaxon:5476
strain M70
PHIPO:0000586		 —
  • PMID:16723566 (PHI-base primary-literature antimicrobial interaction PHIG:1428; joined to this record by exact ChEBI identifier.)
  • DOI:10.1128/aac.01653-05 (Identifier-scope review: Results: resistant derivatives and cross-resistance, Table 3, Declared FKS1 reference accessions, UniProtKB release 2026_03: O13383 entry 50, sequence version 1; A0A1D8PCT0 entry 36, sequence version 1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
FKS1(S645P) (amino acid mutation) [Not assayed] associated with resistance to anidulafungin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review balashov-2006-reference-context: The strain label denotes a parent background, not an individually resolved resistant derivative. Imported protein/strain identifiers are reference-only. AF027295 / AAC49870.1 maps explicitly to UniProtKB:O13383 (CaFKS1; CAI4 reference), not an experimental allele. Source notation remains unnormalized; aggregated zygosity and grouped MICs must not be assigned to individual isolates. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:A0A1D8PCT0.		 — Candida albicans NCBITaxon:5476
strain SC5314
PHIPO:0000586		 —
  • PMID:16723566 (PHI-base primary-literature antimicrobial interaction PHIG:1428; joined to this record by exact ChEBI identifier.)
  • DOI:10.1128/aac.01653-05 (Identifier-scope review: Results: resistant derivatives and cross-resistance, Table 3, Declared FKS1 reference accessions, UniProtKB release 2026_03: O13383 entry 50, sequence version 1; A0A1D8PCT0 entry 36, sequence version 1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
FKS1(S645Y) (amino acid mutation) [Not assayed] associated with resistance to anidulafungin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review balashov-2006-reference-context: The strain label denotes a parent background, not an individually resolved resistant derivative. Imported protein/strain identifiers are reference-only. AF027295 / AAC49870.1 maps explicitly to UniProtKB:O13383 (CaFKS1; CAI4 reference), not an experimental allele. Source notation remains unnormalized; aggregated zygosity and grouped MICs must not be assigned to individual isolates. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:A0A1D8PCT0.		 — Candida albicans NCBITaxon:5476
strain M70
PHIPO:0000586		 —
  • PMID:16723566 (PHI-base primary-literature antimicrobial interaction PHIG:1428; joined to this record by exact ChEBI identifier.)
  • DOI:10.1128/aac.01653-05 (Identifier-scope review: Results: resistant derivatives and cross-resistance, Table 3, Declared FKS1 reference accessions, UniProtKB release 2026_03: O13383 entry 50, sequence version 1; A0A1D8PCT0 entry 36, sequence version 1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay
FKS1(S645Y) (amino acid mutation) [Not assayed] associated with resistance to anidulafungin
This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review balashov-2006-reference-context: The strain label denotes a parent background, not an individually resolved resistant derivative. Imported protein/strain identifiers are reference-only. AF027295 / AAC49870.1 maps explicitly to UniProtKB:O13383 (CaFKS1; CAI4 reference), not an experimental allele. Source notation remains unnormalized; aggregated zygosity and grouped MICs must not be assigned to individual isolates. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:A0A1D8PCT0.		 — Candida albicans NCBITaxon:5476
strain SC5314
PHIPO:0000586		 —
  • PMID:16723566 (PHI-base primary-literature antimicrobial interaction PHIG:1428; joined to this record by exact ChEBI identifier.)
  • DOI:10.1128/aac.01653-05 (Identifier-scope review: Results: resistant derivatives and cross-resistance, Table 3, Declared FKS1 reference accessions, UniProtKB release 2026_03: O13383 entry 50, sequence version 1; A0A1D8PCT0 entry 36, sequence version 1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.)
Cell growth assay

Curation history

  1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Seeded from data/raw/ inventories (ARO, CHEBI)

  2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  6. RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  7. RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  8. RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  9. RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  10. RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  11. REVIEWED_RESISTANCE_IDENTIFIER_SCOPE 2026-10-08 · codex · LLM-assisted

    Scoped eight PHI-base FKS1 associations to parent-background context, withheld reference protein/strain IDs as experimental-subject identifiers, and retained the explicit AF027295-to-UniProtKB:O13383 reference crosswalk. Alleles, phenotypes, species, and mechanism unchanged; no isolate MIC inferred.

  12. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Applied 1 pinned subject-context reviews, retaining reference-locus grounding while withholding unverified experimental protein/strain identifiers. Source alterations, phenotypes, species, genes, and existing activities unchanged. Refreshed provenance checksums on any previously reviewed claims. Resolved the FKS1 table's derivative label with its explicit numbering discrepancy.

  13. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after Eddouzi subject reviews; all biological fields and prior decisions unchanged.

  14. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after Rybak reference-context reviews; all biological fields and previous decisions unchanged.

  15. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after carboxin reference-context reviews; all biological fields, activities and previous decisions unchanged.

  16. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after two additional carboxin identifier-scope corrections; all biological fields, activities and previous decisions unchanged.

  17. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after eleven additional identifier-scope corrections; biological fields, activities and decisions unchanged.

  18. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after seventeen additional identifier-scope corrections; biological fields, activities and decisions unchanged.

  19. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after one yeast identity-scope correction; biological fields, activities and prior decisions unchanged.

  20. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the whole-file PHI-base review checksum after twelve reference-scope corrections; biological fields, activities and prior decisions unchanged.

  21. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after nine identifier-scope corrections; previous decisions, biological fields and activities unchanged.

  22. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after six identifier-scope corrections; previous decisions, biological fields and activities unchanged.

  23. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after eight subject-identity corrections; previous decisions, biological fields and activities unchanged.

  24. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Darlington subject correction; prior review decisions, biological fields and activities unchanged.

  25. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Nakayama reference-scope review; prior decisions, biological fields and activities unchanged.

  26. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Duan reference-scope review; prior decisions, biological fields and activities unchanged.

  27. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Piotrowska parent-reference review; prior decisions, biological fields and activities unchanged.

  28. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Xu subject and species corrections; prior decisions, biological fields and activities unchanged.

  29. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Shima parent-reference review; prior decisions, biological fields and activities unchanged.

  30. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Mehrabi parent-reference review; prior decisions, biological fields and activities unchanged.

  31. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Huang parent-reference review; prior decisions, biological fields and activities unchanged.

  32. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-09 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the HDF1 subject-reference review; prior decisions, biological fields and activities unchanged.

  33. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-09 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the Fouche parent-cohort review; prior decisions, biological fields and activities unchanged.

  34. REVIEWED_RESISTANCE_REFERENCE_CONTEXT 2026-10-09 · codex · LLM-assisted

    Refreshed shared PHI-base review checksum after the SDH8 reference-alias correction; prior decisions, biological fields and activities unchanged.

  35. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-09 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after the Posteraro subject-context review; previous decisions, biological fields and activities unchanged.

  36. REVIEWED_RESISTANCE_REFERENCE_CONTEXT 2026-10-12 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after four reference-identifier scope corrections; previous decisions, biological fields and activities unchanged.

  37. REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-13 · codex · LLM-assisted

    Refreshed the shared PHI-base review checksum after one Neurospora subject-context correction; previous decisions, biological fields and activities unchanged.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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