boscalid

CHEBI:81822 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A pyridinecarboxamide obtained by formal condensation of the carboxy group of 2-chloronicotinic acid with the amino group of 4'-chlorobiphenyl-2-amine. A fungicide active against a broad range of fungal pathogens including Botrytis spp., Alternaria spp. and Sclerotinia spp. for use on a wide range of crops including fruit, vegetables and ornamentals. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

fungal succinate dehydrogenase inhibitorARO:3009539

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:22888 CHEBI:22888
CHEBI:25529 CHEBI:25529
CHEBI:83403 CHEBI:83403
CHEBI:87015 CHEBI:87015
ARO:3009539 ARO:3009539

Chemical structure

Computed structure properties
Molecular formula	C18H12Cl2N2O
Charge	0
Average mass	343.213 Da
Monoisotopic mass	342.03267 Da
Source	ChEBI
InChIKey	WYEMLYFITZORAB-UHFFFAOYSA-N

SMILES

O=C(Nc1ccccc1-c1ccc(Cl)cc1)c1cccnc1Cl

InChI

InChI=1S/C18H12Cl2N2O/c19-13-9-7-12(8-10-13)14-4-1-2-6-16(14)22-18(23)15-5-3-11-21-17(15)20/h1-11H,(H,22,23)

Also called

2-chloro-N-(4'-chlorobiphenyl-2-yl)nicotinamide (EXACT_SYNONYM)— chebi
2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)-3-pyridinecarboxamide (EXACT_SYNONYM)— chebi
2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)pyridine-3-carboxamide (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:24127 CHEBI:24127
CHEBI:35718 CHEBI:35718
CHEBI:86328 CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3009186`	boscalid	`antibioticmech:aro-64f9ab31fd`	2026-08-30
CHEBI	`CHEBI:81822`	boscalid	`antibioticmech:chebi-3c183d63fb`	2026-08-30

Mechanism summary

Mode of action: ENERGY_METABOLISM_INHIBITION host shared target — Assigned from ChEBI role CHEBI:83072 (EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Resistance mechanisms

3 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 3

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Aspergillus fumigatus Cyp51A with mutations conferring resistance to benomyl	ARO:3009543	not organism-specific	—	ARO:3009543 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009186 (boscalid); database assertion, not a primary citation.)
Aspergillus fumigatus Cyp51A with mutations conferring resistance to boscalid	ARO:3009550	not organism-specific	—	ARO:3009550 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009186 (boscalid); database assertion, not a primary citation.)
Aspergillus fumigatus beta-tubulin with mutations conferring resistance to boscalid	ARO:3009481	not organism-specific	—	ARO:3009481 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009186 (boscalid); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.