AntibioticMech

Browse · ANTIFUNGAL

boscalid

CHEBI:81822 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A pyridinecarboxamide obtained by formal condensation of the carboxy group of 2-chloronicotinic acid with the amino group of 4'-chlorobiphenyl-2-amine. A fungicide active against a broad range of fungal pathogens including Botrytis spp., Alternaria spp. and Sclerotinia spp. for use on a wide range of crops including fruit, vegetables and ornamentals. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

fungal succinate dehydrogenase inhibitorARO:3009539

Strictly broader compounds or drug classes this molecule belongs to.

Chemical structure

Computed structure properties
Molecular formulaC18H12Cl2N2O
Charge0
Average mass343.213 Da
Monoisotopic mass342.03267 Da
SourceChEBI
InChIKeyWYEMLYFITZORAB-UHFFFAOYSA-N

SMILES

O=C(Nc1ccccc1-c1ccc(Cl)cc1)c1cccnc1Cl

InChI

InChI=1S/C18H12Cl2N2O/c19-13-9-7-12(8-10-13)14-4-1-2-6-16(14)22-18(23)15-5-3-11-21-17(15)20/h1-11H,(H,22,23)

Also called

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
SourceNative IDLabelMinted CURIEVersion
ARO ARO:3009186 boscalid antibioticmech:aro-64f9ab31fd 2026-08-30
CHEBI CHEBI:81822 boscalid antibioticmech:chebi-3c183d63fb 2026-08-30

Mechanism summary

Mode of action
ENERGY_METABOLISM_INHIBITION host shared target — Assigned from ChEBI role CHEBI:83072 (EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Resistance mechanisms

3 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 3
ANTIBIOTIC_TARGET_ALTERATION
DeterminantARO IDOrganismGene familiesEvidence
Aspergillus fumigatus Cyp51A with mutations conferring resistance to benomyl ARO:3009543 not organism-specific —
  • ARO:3009543 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009186 (boscalid); database assertion, not a primary citation.)
Aspergillus fumigatus Cyp51A with mutations conferring resistance to boscalid ARO:3009550 not organism-specific —
  • ARO:3009550 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009186 (boscalid); database assertion, not a primary citation.)
Aspergillus fumigatus beta-tubulin with mutations conferring resistance to boscalid ARO:3009481 not organism-specific —
  • ARO:3009481 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009186 (boscalid); database assertion, not a primary citation.)

Curation history

  1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Seeded from data/raw/ inventories (ARO, CHEBI)

  2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

  3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

    Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

Explore across X-Mech: MediaIngredientMech (boscalid) · CultureMech · NaturalProductMech · PathwayMech · TraitMech