(E,E)-germacrone

CHEBI:80830 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A germacrane sesquiterpenoid that has formula C15H22O. It is a natural product found in traditional medicinal plants of the family Zingiberaceae. The compound exhibits a range of pharmacological activities including anti-inflammatory, anticancer, antiviral, anti-androgenic, antioxidant, antimicrobial, antifungal, neuroprotective and insecticidal activities. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:68588 CHEBI:68588
CHEBI:78840 CHEBI:78840

Chemical structure

Computed structure properties
Molecular formula	C15H22O
Charge	0
Average mass	218.34 Da
Monoisotopic mass	218.16707 Da
Source	ChEBI
InChIKey	CAULGCQHVOVVRN-SWZPTJTJSA-N

SMILES

CC(C)=C1C/C=C(\C)CC/C=C(\C)CC1=O

InChI

InChI=1S/C15H22O/c1-11(2)14-9-8-12(3)6-5-7-13(4)10-15(14)16/h7-8H,5-6,9-10H2,1-4H3/b12-8+,13-7+

Also called

(3E,7E)-3,7-dimethyl-10-(propan-2-ylidene)cyclodeca-3,7-dien-1-one (EXACT_SYNONYM)— chebi
(3E,7E)-3,7-dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one (EXACT_SYNONYM)— chebi
germacron (EXACT_SYNONYM)— chebi
germacrone (EXACT_SYNONYM)— chebi
trans,trans-3,7-dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:6902-91-6
chemspider:4940991
foodb.food:FDB005347
kegg.compound:C16966
knapsack:C00011728
reaxys:2047453
wikipedia.en:Germacrone

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:22587 CHEBI:22587
CHEBI:33281 CHEBI:33281
CHEBI:35718 CHEBI:35718

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:80830`	(E,E)-germacrone	`antibioticmech:chebi-aec16cc3e9`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.