ferrostatin-1

CHEBI:173086 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

An ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:23990 CHEBI:23990
CHEBI:48975 CHEBI:48975
CHEBI:50471 CHEBI:50471

Chemical structure

Computed structure properties
Molecular formula	C15H22N2O2
Charge	0
Average mass	262.353 Da
Monoisotopic mass	262.16813 Da
Source	ChEBI
InChIKey	UJHBVMHOBZBWMX-UHFFFAOYSA-N

SMILES

CCOC(=O)c1ccc(NC2CCCCC2)c(N)c1

InChI

InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3

Also called

ethyl 3-amino-4-(cyclohexylamino)benzoate (EXACT_SYNONYM)— chebi
3-amino-4-cyclohexylaminobenzoic acid ethyl ester (EXACT_SYNONYM)— chebi
Fer-1 (EXACT_SYNONYM)— chebi
ferrrostatin 1 (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:347174-05-4

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:35718 CHEBI:35718

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:173086`	ferrostatin-1	`antibioticmech:chebi-8db000c353`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.