fludioxonil
A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria .
Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.
Classification
antibiotic without defined classificationARO:3000003
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CHEBI:18379 -
CHEBI:26455 -
CHEBI:37143 -
CHEBI:38298 - antibiotic without defined classification
ARO:3000003
Chemical structure
| Molecular formula | C12H6F2N2O2 |
|---|---|
| Charge | 0 |
| Average mass | 248.188 Da |
| Monoisotopic mass | 248.03973 Da |
| Source | ChEBI |
| InChIKey | MUJOIMFVNIBMKC-UHFFFAOYSA-N |
N#Cc1cncc1-c1cccc2c1OC(F)(F)O2
InChI=1S/C12H6F2N2O2/c13-12(14)17-10-3-1-2-8(11(10)18-12)9-6-16-5-7(9)4-15/h1-3,5-6,16H
Also called
- 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile
Cross-references
- fludioxinil
ARO:3009167 - cas:131341-86-1
- kegg.compound:C18462
- pesticides:fludioxonil
- ppdb:330
- reaxys:8393936
- CHEBI:191042
- chembl:CHEMBL485833
- pubchem.compound:86398
Activity roles
- antifungal agrochemical
CHEBI:86328
Source concepts
| Source | Native ID | Label | Minted CURIE | Version |
|---|---|---|---|---|
| ARO | ARO:3009167 |
fludioxinil | antibioticmech:aro-d96d84da79 |
2026-08-30 |
| CHEBI | CHEBI:81763 |
fludioxonil | antibioticmech:chebi-260b6ee3f5 |
2026-08-30 |
Resistance mechanisms
UNKNOWN 13
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|---|---|---|---|
| Bos1(18.3 (55bp) duplication 835 + 838stop) (amino acid insertion and mutation) [Not assayed] associated with resistance to fludioxonil |
— | Botrytis cinerea NCBITaxon:40559PHIPO:0000592 |
— | |
| Bos1(E253D) (amino acid mutation) [Not assayed] associated with resistance to fludioxonil |
— | Botrytis cinerea NCBITaxon:40559PHIPO:0000592 |
— | |
| Bos1(G415D) (amino acid mutation) [Not assayed] associated with resistance to fludioxonil |
— | Botrytis cinerea NCBITaxon:40559PHIPO:0000592 |
— | |
| Bos1(Q846stop) (nonsense mutation) [Not assayed] associated with resistance to fludioxonil |
— | Botrytis cinerea NCBITaxon:40559PHIPO:0000592 |
— | |
| FgSch9delta (deletion) associated with resistance to fludioxonil |
— | Fusarium graminearum NCBITaxon:5518NCBITaxon:229533UniProtKB:I1RAE5PHIPO:0000592 |
— | |
| HOG1delta (deletion) associated with resistance to fludioxonil |
— | Fusarium graminearum NCBITaxon:5518NCBITaxon:229533UniProtKB:P0C431 PHIPO:0000592 |
— | |
| Hog1::Hyg (disruption) [Not assayed] associated with resistance to fludioxonil |
— | Zymoseptoria tritici NCBITaxon:1047171PHIPO:0000592 |
— | |
| Hog1delta (deletion) associated with resistance to fludioxonil |
— | Fusarium verticillioides NCBITaxon:117187PHIPO:0000592 |
— | |
| Hog1delta (deletion) associated with resistance to fludioxonil |
— | Sclerotinia sclerotiorum NCBITaxon:5180PHIPO:0000592 |
— | |
| OS-2delta (deletion) associated with resistance to fludioxonil |
— | Fusarium graminearum NCBITaxon:5518NCBITaxon:229533UniProtKB:P0C431 PHIPO:0000592 |
— | |
| Pbs2delta (deletion) associated with resistance to fludioxonil |
— | Fusarium verticillioides NCBITaxon:117187PHIPO:0000592 |
— | |
| Shk1delta (deletion) associated with resistance to fludioxonil |
— | Sclerotinia sclerotiorum NCBITaxon:5180PHIPO:0000592 |
— | |
| Ssk2delta (deletion) associated with resistance to fludioxonil |
— | Fusarium verticillioides NCBITaxon:117187PHIPO:0000592 |
— |
Curation history
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SEEDED_FROM_SOURCES
Seeded from data/raw/ inventories (ARO, CHEBI)
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RESEEDED_FROM_SOURCES
Re-seeded from updated data/raw/ inventories
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RESEEDED_FROM_SOURCES
Re-seeded from updated data/raw/ inventories
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RESEEDED_FROM_SOURCES
Re-seeded from updated data/raw/ inventories
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RESEEDED_FROM_SOURCES
Re-seeded from updated data/raw/ inventories
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RESEEDED_FROM_SOURCES
Re-seeded from updated data/raw/ inventories
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Resolved three fludioxonil subject labels from primary Results, retaining unresolved individual clones and parent lineage. Reference proteins and 7600 TaxID withheld from subject fields; no new allele, MIC or genome inferred.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed the whole-file PHI-base review checksum after seventeen additional identifier-scope corrections; biological fields, activities and decisions unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed the whole-file PHI-base review checksum after one yeast identity-scope correction; biological fields, activities and prior decisions unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed the whole-file PHI-base review checksum after twelve reference-scope corrections; biological fields, activities and prior decisions unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed the shared PHI-base review checksum after nine identifier-scope corrections; previous decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed the shared PHI-base review checksum after six identifier-scope corrections; previous decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Corrected parental labels to primary-table tested-subject labels; moved B05.10 reference identifiers into provenance. Source biological fields and activities unchanged. No exact experimental allele, genome or measurement inferred.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed shared PHI-base review checksum after the Darlington subject correction; prior review decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed shared PHI-base review checksum after the Nakayama reference-scope review; prior decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed shared PHI-base review checksum after the Duan reference-scope review; prior decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed shared PHI-base review checksum after the Piotrowska parent-reference review; prior decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed shared PHI-base review checksum after the Xu subject and species corrections; prior decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed shared PHI-base review checksum after the Shima parent-reference review; prior decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Scoped IPO323 reference protein and strain TaxID to provenance after primary identity review. Parent label, reference locus, source flags, phenotype and activities preserved; grouped subjects not assigned individual accessions.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed shared PHI-base review checksum after the Huang parent-reference review; prior decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed shared PHI-base review checksum after the HDF1 subject-reference review; prior decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed shared PHI-base review checksum after the Fouche parent-cohort review; prior decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_REFERENCE_CONTEXT
Refreshed shared PHI-base review checksum after the SDH8 reference-alias correction; prior decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed the shared PHI-base review checksum after the Posteraro subject-context review; previous decisions, biological fields and activities unchanged.
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REVIEWED_RESISTANCE_REFERENCE_CONTEXT
Moved reference protein and strain TaxID into provenance for two PHI-base associations after a limited primary-supplement and UniProt identity review. Retained species and source strain label with unresolved subject context; no allele, phenotype, assay, measurement or mechanism changed. Exact experimental accessions remain unresolved.
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REVIEWED_RESISTANCE_SUBJECT_CONTEXT
Refreshed the shared PHI-base review checksum after one Neurospora subject-context correction; previous decisions, biological fields and activities unchanged.