AntibioticMech

fludioxonil

CHEBI:81763 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria . — ChEBI

Classification

antibiotic without defined classificationARO:3000003

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:18379 CHEBI:18379
• CHEBI:26455 CHEBI:26455
• CHEBI:37143 CHEBI:37143
• CHEBI:38298 CHEBI:38298
• ARO:3000003 ARO:3000003

Chemical structure

Computed structure properties

Molecular formula	C12H6F2N2O2
Charge	0
Average mass	248.188 Da
Monoisotopic mass	248.03973 Da
Source	ChEBI
InChIKey	MUJOIMFVNIBMKC-UHFFFAOYSA-N

SMILES

N#Cc1cncc1-c1cccc2c1OC(F)(F)O2

InChI

InChI=1S/C12H6F2N2O2/c13-12(14)17-10-3-1-2-8(11(10)18-12)9-6-16-5-7(9)4-15/h1-3,5-6,16H

Also called

• 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• ARO:3009167
• cas:131341-86-1
• kegg.compound:C18462
• pesticides:fludioxonil
• ppdb:330
• reaxys:8393936
• CHEBI:191042
• chembl:CHEMBL485833
• pubchem.compound:86398

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:86328 CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
ARO	ARO:3009167	fludioxinil	antibioticmech:aro-d96d84da79	2026-08-30
CHEBI	CHEBI:81763	fludioxonil	antibioticmech:chebi-260b6ee3f5	2026-08-30

Resistance mechanisms

13 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

UNKNOWN 13

UNKNOWN

Determinant	ARO ID	Organism	Gene families	Evidence
Bos1(18.3 (55bp) duplication 835 + 838stop) (amino acid insertion and mutation) [Not assayed] associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Botrytis cinerea NCBITaxon:40559 strain Bt6-4 NCBITaxon:332648 UniProtKB:A0A384J5Y1 PHIPO:0000592	—	PMID:30686204 (PHI-base primary-literature antimicrobial interaction PHIG:4721; joined to this record by exact ChEBI identifier.) Cell growth assay
Bos1(E253D) (amino acid mutation) [Not assayed] associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Botrytis cinerea NCBITaxon:40559 strain Bt3-4 NCBITaxon:332648 UniProtKB:A0A384J5Y1 PHIPO:0000592	—	PMID:30686204 (PHI-base primary-literature antimicrobial interaction PHIG:4721; joined to this record by exact ChEBI identifier.) Cell growth assay
Bos1(G415D) (amino acid mutation) [Not assayed] associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Botrytis cinerea NCBITaxon:40559 strain Yc-6 NCBITaxon:332648 UniProtKB:A0A384J5Y1 PHIPO:0000592	—	PMID:30686204 (PHI-base primary-literature antimicrobial interaction PHIG:4721; joined to this record by exact ChEBI identifier.) Cell growth assay
Bos1(Q846stop) (nonsense mutation) [Not assayed] associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Botrytis cinerea NCBITaxon:40559 strain Nj5-10 NCBITaxon:332648 UniProtKB:A0A384J5Y1 PHIPO:0000592	—	PMID:30686204 (PHI-base primary-literature antimicrobial interaction PHIG:4721; joined to this record by exact ChEBI identifier.) Cell growth assay
FgSch9delta (deletion) associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Fusarium graminearum NCBITaxon:5518 strain PH-1 NCBITaxon:229533 UniProtKB:I1RAE5 PHIPO:0000592	—	PMID:24903410 (PHI-base primary-literature antimicrobial interaction PHIG:11; joined to this record by exact ChEBI identifier.) Cell growth assay
HOG1delta (deletion) associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Fusarium graminearum NCBITaxon:5518 strain PH-1 NCBITaxon:229533 UniProtKB:P0C431 FGRAMPH1_01T26671 PHIPO:0000592	—	PMID:24903410 (PHI-base primary-literature antimicrobial interaction PHIG:7590; joined to this record by exact ChEBI identifier.) Cell growth assay
Hog1::Hyg (disruption) [Not assayed] associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Zymoseptoria tritici NCBITaxon:1047171 strain IPO323 NCBITaxon:336722 UniProtKB:Q1KTF2 Mycgr3T76502 PHIPO:0000592	—	PMID:17073308 (PHI-base primary-literature antimicrobial interaction PHIG:9481; joined to this record by exact ChEBI identifier.) Cell growth assay
Hog1delta (deletion) associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Fusarium verticillioides NCBITaxon:117187 strain Unknown strain NCBITaxon:334819 UniProtKB:W7M468 PHIPO:0000592	—	PMID:41649761 (PHI-base primary-literature antimicrobial interaction PHIG:11392; joined to this record by exact ChEBI identifier.) Cell growth assay
Hog1delta (deletion) associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Sclerotinia sclerotiorum NCBITaxon:5180 strain Scl02-05 NCBITaxon:665079 UniProtKB:A7EQI8 PHIPO:0000592	—	PMID:38374637 (PHI-base primary-literature antimicrobial interaction PHIG:10483; joined to this record by exact ChEBI identifier.) Cell growth assay
OS-2delta (deletion) associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Fusarium graminearum NCBITaxon:5518 strain PH-1 NCBITaxon:229533 UniProtKB:P0C431 FGRAMPH1_01T26671 PHIPO:0000592	—	PMID:22591226 (PHI-base primary-literature antimicrobial interaction PHIG:7590; joined to this record by exact ChEBI identifier.) Cell growth assay
Pbs2delta (deletion) associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Fusarium verticillioides NCBITaxon:117187 strain Unknown strain NCBITaxon:334819 UniProtKB:W7LTW3 PHIPO:0000592	—	PMID:41649761 (PHI-base primary-literature antimicrobial interaction PHIG:11388; joined to this record by exact ChEBI identifier.) Cell growth assay
Shk1delta (deletion) associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Sclerotinia sclerotiorum NCBITaxon:5180 strain Scl02-05 NCBITaxon:665079 UniProtKB:A7F519 PHIPO:0000592	—	PMID:38374637 (PHI-base primary-literature antimicrobial interaction PHIG:7818; joined to this record by exact ChEBI identifier.) Cell growth assay
Ssk2delta (deletion) associated with resistance to fludioxonil This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Fusarium verticillioides NCBITaxon:117187 strain Unknown strain NCBITaxon:334819 UniProtKB:W7LX41 PHIPO:0000592	—	PMID:41649761 (PHI-base primary-literature antimicrobial interaction PHIG:11389; joined to this record by exact ChEBI identifier.) Cell growth assay

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO, CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

6. RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.