flusilazole

CHEBI:81922 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

An organosilicon compound that is dimethylsilane in which the hydrogens attached to the silicon are replaced by p-fluorophenyl groups and a hydrogen attached to one of the methyl groups is replaced by a 1H-1,2,4-triazol-1-yl group. It is a broad-sepctrum fungicide used to protect a variety of crops. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

triazole antifungalARO:3007499

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:25713
Label unavailable CHEBI:35727
Label unavailable CHEBI:83575
conazole fungicide CHEBI:87067
triazole fungicide CHEBI:87100
triazole antifungal ARO:3007499

Chemical structure

Computed structure properties
Molecular formula	C16H15F2N3Si
Charge	0
Average mass	315.399 Da
Monoisotopic mass	315.10033 Da
Source	ChEBI
InChIKey	FQKUGOMFVDPBIZ-UHFFFAOYSA-N

SMILES

C[Si](Cn1cncn1)(c1ccc(F)cc1)c1ccc(F)cc1

InChI

InChI=1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3

Also called

Nustar (BRAND_NAME)— chebi
1-{[bis(4-fluorophenyl)(methyl)silyl]methyl}-1H-1,2,4-triazole (EXACT_SYNONYM)— chebi
1-[[bis(4-fluorophenyl)methylsilyl]methyl]-1H-1,2,4-triazole (EXACT_SYNONYM)— chebi
DPX-H 6573 (EXACT_SYNONYM)— chebi
bis(4-fluorophenyl)(methyl)(1H-1,2,4-triazol-1-ylmethyl)silane (EXACT_SYNONYM)— chebi
di(4-fluorophenyl)(1,2,4-triazole-2-ylmethyl)methylsilane (EXACT_SYNONYM)— chebi
flusilazol (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

fungicide CHEBI:24127
antifungal agent CHEBI:35718
EC 1.14.13.70 (sterol 14α-demethylase) inhibitor CHEBI:77884
antifungal agrochemical CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3009408`	flusilazole	`antibioticmech:aro-88092e6731`	2026-08-30
CHEBI	`CHEBI:81922`	flusilazole	`antibioticmech:chebi-7110ab8610`	2026-08-30

Mechanism summary

Mode of action: ERGOSTEROL_PATHWAY_INHIBITION host shared target — Assigned from ChEBI role CHEBI:75282 (ergosterol biosynthesis inhibitor), CHEBI:77884 (EC 1.14.13.70 (sterol 14α-demethylase) inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Resistance mechanisms

4 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 4

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Pyrenopeziza brassicae Cyp51 with mutations conferring resistance to flusilazole	ARO:3009535	not organism-specific	—	ARO:3009535 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009408 (flusilazole); database assertion, not a primary citation.)
Tapesia acuformis Cyp51 with mutations conferring resistance to flusilazole	ARO:3009541	not organism-specific	—	ARO:3009541 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009408 (flusilazole); database assertion, not a primary citation.)
Tapesia yallundae Cyp51 with mutations conferring resistance to flusilazole	ARO:3009542	not organism-specific	—	ARO:3009542 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009408 (flusilazole); database assertion, not a primary citation.)
Zymoseptoria tritici Cyp51 with mutations conferring resistance to flusilazole	ARO:3009409	not organism-specific	—	ARO:3009409 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009408 (flusilazole); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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