flusilazole

CHEBI:81922 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

An organosilicon compound that is dimethylsilane in which the hydrogens attached to the silicon are replaced by p-fluorophenyl groups and a hydrogen attached to one of the methyl groups is replaced by a 1H-1,2,4-triazol-1-yl group. It is a broad-sepctrum fungicide used to protect a variety of crops. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

triazole antifungalARO:3007499

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:25713 CHEBI:25713
CHEBI:35727 CHEBI:35727
CHEBI:83575 CHEBI:83575
CHEBI:87067 CHEBI:87067
CHEBI:87100 CHEBI:87100
ARO:3007499 ARO:3007499

Chemical structure

Computed structure properties
Molecular formula	C16H15F2N3Si
Charge	0
Average mass	315.399 Da
Monoisotopic mass	315.10033 Da
Source	ChEBI
InChIKey	FQKUGOMFVDPBIZ-UHFFFAOYSA-N

SMILES

C[Si](Cn1cncn1)(c1ccc(F)cc1)c1ccc(F)cc1

InChI

InChI=1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3

Also called

Nustar (BRAND_NAME)— chebi
1-{[bis(4-fluorophenyl)(methyl)silyl]methyl}-1H-1,2,4-triazole (EXACT_SYNONYM)— chebi
1-[[bis(4-fluorophenyl)methylsilyl]methyl]-1H-1,2,4-triazole (EXACT_SYNONYM)— chebi
DPX-H 6573 (EXACT_SYNONYM)— chebi
bis(4-fluorophenyl)(methyl)(1H-1,2,4-triazol-1-ylmethyl)silane (EXACT_SYNONYM)— chebi
di(4-fluorophenyl)(1,2,4-triazole-2-ylmethyl)methylsilane (EXACT_SYNONYM)— chebi
flusilazol (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3009408
cas:85509-19-9
cas:96827-34-8
hmdb:HMDB0039815
kegg.compound:C18733
patent:EP68813
patent:US4510136
pesticides:flusilazole
ppdb:350
reaxys:5824097
wikipedia.en:Flusilazole
chembl:CHEMBL1900522
pubchem.compound:73675

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:24127 CHEBI:24127
CHEBI:35718 CHEBI:35718
CHEBI:77884 CHEBI:77884
CHEBI:86328 CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3009408`	flusilazole	`antibioticmech:aro-88092e6731`	2026-08-30
CHEBI	`CHEBI:81922`	flusilazole	`antibioticmech:chebi-7110ab8610`	2026-08-30

Mechanism summary

Mode of action: ERGOSTEROL_PATHWAY_INHIBITION host shared target — Assigned from ChEBI role CHEBI:75282 (ergosterol biosynthesis inhibitor), CHEBI:77884 (EC 1.14.13.70 (sterol 14α-demethylase) inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Resistance mechanisms

4 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 4

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Pyrenopeziza brassicae Cyp51 with mutations conferring resistance to flusilazole	ARO:3009535	not organism-specific	—	ARO:3009535 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009408 (flusilazole); database assertion, not a primary citation.)
Tapesia acuformis Cyp51 with mutations conferring resistance to flusilazole	ARO:3009541	not organism-specific	—	ARO:3009541 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009408 (flusilazole); database assertion, not a primary citation.)
Tapesia yallundae Cyp51 with mutations conferring resistance to flusilazole	ARO:3009542	not organism-specific	—	ARO:3009542 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009408 (flusilazole); database assertion, not a primary citation.)
Zymoseptoria tritici Cyp51 with mutations conferring resistance to flusilazole	ARO:3009409	not organism-specific	—	ARO:3009409 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009408 (flusilazole); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.