flutrimazole

CHEBI:82864 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

An imidazole antifungal agent that is imidazole in which the hydrogen attached to the nitrogen is replaced by a 2,4'-difluorotrityl group. A topical antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:24780 CHEBI:24780
CHEBI:83575 CHEBI:83575
CHEBI:87069 CHEBI:87069

Chemical structure

Computed structure properties
Molecular formula	C22H16F2N2
Charge	0
Average mass	346.38 Da
Monoisotopic mass	346.12815 Da
Source	ChEBI
InChIKey	QHMWCHQXCUNUAK-UHFFFAOYSA-N

SMILES

Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1

InChI

InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H

Also called

flutrimazol (INN)— chebi
flutrimazolum (INN)— chebi
1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole (EXACT_SYNONYM)— chebi
1-(2,4'-difluorotrityl)imidazole (EXACT_SYNONYM)— chebi
1-(o-Fluoro-alpha-(p-fluorophenyl)-alpha-phenylbenzyl)imidazole (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:119006-77-8
drugcentral:1227
kegg.drug:D07193
patent:WO9920271
reaxys:5383184
wikipedia.en:Flutrimazole

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:35718 CHEBI:35718
CHEBI:77884 CHEBI:77884
CHEBI:86327 CHEBI:86327

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:82864`	flutrimazole	`antibioticmech:chebi-b59073a325`	2026-08-30

Mechanism summary

Mode of action: ERGOSTEROL_PATHWAY_INHIBITION host shared target — Assigned from ChEBI role CHEBI:77884 (EC 1.14.13.70 (sterol 14α-demethylase) inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.