FR171456

CHEBI:88298 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A steroid acid that is 9β,19-cyclo-5α-ergost-24(28)-ene-4α-carboxylic acid which is substituted by hydroxy groups at the 3β, 8α, and 11α positions, by a methyl group at the 4β position, and by oxo groups at positions 1 and 6. It is a cholesterol and ergosterol synthesis inhibitor isolated from the fungus Sporormiella minima that specifically targets the enzyme, sterol-4-alpha-carboxylate-3-dehydrogenase, encoded by ERG26 in budding yeast, and NSDHL in humans. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:139333
Label unavailable CHEBI:19129
Label unavailable CHEBI:36836
Label unavailable CHEBI:36883
Label unavailable CHEBI:47891
Label unavailable CHEBI:51454

Chemical structure

Computed structure properties
Molecular formula	C30H44O7
Charge	0
Average mass	516.675 Da
Monoisotopic mass	516.3087 Da
Source	ChEBI
InChIKey	JAHGNOXPMXOEJS-BSPLYONXSA-N

SMILES

[H][C@@]12CC[C@]([H])([C@H](C)CCC(=C)C(C)C)[C@@]1(C)C[C@@H](O)[C@@]13C[C@@]14C(=O)C[C@H](O)[C@@](C)(C(=O)O)[C@]4([H])C(=O)C[C@]23O

InChI

InChI=1S/C30H44O7/c1-15(2)16(3)7-8-17(4)18-9-10-20-26(18,5)13-23(34)29-14-28(29)22(33)11-21(32)27(6,25(35)36)24(28)19(31)12-30(20,29)37/h15,17-18,20-21,23-24,32,34,37H,3,7-14H2,1-2,4-6H3,(H,35,36)/t17-,18-,20-,21+,23-,24+,26-,27-,28+,29+,30+/m1/s1

Also called

3β,8α,11α-trihydroxy-4-methyl-1,6-dioxo-9β,19-cyclo-5α-ergost-24(28)-ene-4α-carboxylic acid (EXACT_SYNONYM)— chebi
(3β,4α,5α,8α,9β,11α)-3,8,11-trihydroxy-4-methyl-1,6-dioxo-9,19-cycloergost-24(28)-ene-4-carboxylic acid (EXACT_SYNONYM)— chebi

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antifungal agent CHEBI:35718

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:88298`	FR171456	`antibioticmech:chebi-133d18380b`	2026-08-30

Mechanism summary

Mode of action: ERGOSTEROL_PATHWAY_INHIBITION host shared target — Assigned from ChEBI role CHEBI:75282 (ergosterol biosynthesis inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Resistance mechanisms

1 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 1

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
ERG26-associated FR171456 resistance in laboratory yeast Gene-level functional evidence in laboratory derivatives, not a clinical or species-wide phenotype. Some resistant isolates lacked ERG26 changes and remain unexplained. UniProtKB:P53199 (S288c) is reference context, not an experimental allele. No exact allele, protein accession, derivative TaxID or genome is assigned. Named-compound scope does not independently re-identify the tested preparation.	—	Saccharomyces cerevisiae `NCBITaxon:4932`	ERG26	PMID:26456460 (Results, Figure 3a, Supplementary Figure 6 and Table 3; qualitative gene-level evidence.) Comparative growth dose-response assay

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
CURATED_RESISTANCE_EVIDENCE 2026-10-11 · codex · LLM-assisted
Added primary-supported qualitative ERG26 resistance evidence in laboratory yeast. Grounded species taxonomy while retaining UniProt as reference-only context. Preserved source fields and prior history; no exact alleles, genomes or numerical AST assigned. Whole-record review remains open.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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