kresoxim-methyl

CHEBI:2962 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A carboxylic ester that is the methyl ester of (2E)-(methoxyimino){2-[(2-methylphenoxy)methyl]phenyl}acetic acid. A fungicide for the control of scab on apples and pears and other fungal diseases on a wide range of crops. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

strobilurin fungicideARO:3009305

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:25248 CHEBI:25248
CHEBI:35618 CHEBI:35618
CHEBI:36816 CHEBI:36816
CHEBI:86488 CHEBI:86488
ARO:3009305 ARO:3009305

Chemical structure

Computed structure properties
Molecular formula	C18H19NO4
Charge	0
Average mass	313.353 Da
Monoisotopic mass	313.13141 Da
Source	ChEBI
InChIKey	ZOTBXTZVPHCKPN-HTXNQAPBSA-N

SMILES

CO/N=C(/C(=O)OC)c1ccccc1COc1ccccc1C

InChI

InChI=1S/C18H19NO4/c1-13-8-4-7-11-16(13)23-12-14-9-5-6-10-15(14)17(19-22-3)18(20)21-2/h4-11H,12H2,1-3H3/b19-17+

Also called

methyl (2E)-(methoxyimino){2-[(2-methylphenoxy)methyl]phenyl}acetate (EXACT_SYNONYM)— chebi
BAS 490 F (EXACT_SYNONYM)— chebi
Methyl (E)-alpha-(methoxyimino)-2-((2-methylphenoxy)methyl)benzeneacetate (EXACT_SYNONYM)— chebi
methyl (E)-methoxyimino[α-(o-tolyloxy)-o-tolyl]acetate (EXACT_SYNONYM)— chebi
methyl (αE)-α-(methoxyimino)-2-[(2-methylphenoxy)methyl]benzeneacetate (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3009307
cas:143390-89-0
kegg.compound:C11017
pesticides:kresoxim-methyl
ppdb:414
reaxys:8330581
chembl:CHEMBL203191
pubchem.compound:6112114

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:35718 CHEBI:35718
CHEBI:86328 CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3009307`	kresoxim-methyl	`antibioticmech:aro-560ad1417d`	2026-08-30
CHEBI	`CHEBI:2962`	kresoxim-methyl	`antibioticmech:chebi-6715ce8bf2`	2026-08-30

Mechanism summary

Mode of action: ENERGY_METABOLISM_INHIBITION host shared target — Assigned from ChEBI role CHEBI:38499 (mitochondrial cytochrome-bc1 complex inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Resistance mechanisms

1 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 1

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Colletotrichum gloeosporioides cytochrome b protein with mutations associated with resistance to kresoxim-methyl	ARO:3009281	not organism-specific	—	ARO:3009281 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009307 (kresoxim-methyl); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.