mebendazole
antibioticmech:aro-adaab5b65b
·ANTIFUNGAL
·MINTED
SEEDED
Mebendazole has a role as an antinematodal drug, a tubulin modulator, and a fungal microtubule-destabilising agent. — PMID:35149760
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
benzimidazole antifungalARO:3009317
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C16H13N3O3 |
|---|
| Charge | 0 |
|---|
| Average mass | 295.29 Da |
|---|
| Monoisotopic mass | 295.09569129 Da |
|---|
| Source | PubChem · retrieved 2026-08-29 |
|---|
| InChIKey | OPXLLQIJSORQAM-UHFFFAOYSA-N |
|---|
SMILES
COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3
InChI
InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3009184 |
mebendazole |
antibioticmech:aro-adaab5b65b |
2026-08-30 |
Mechanism summary
- Clinical status
- APPROVED
Resistance mechanisms
1 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 1
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Saccharomyces cerevisiae with mutations conferring resistance to mebendazole |
ARO:3009477 |
not organism-specific |
— |
- ARO:3009477 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009184 (mebendazole); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.