metconazole

CHEBI:81773 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A member of the class of cyclopentanols carrying 1,2,4-triazol-1-ylmethyl and 4-chlorobenzyl and geminal dimethyl substituents at positions 1, 2 and 5 respectively. Used to control a range of fungal infections including alternaria, rusts, fusarium and septoria diseases. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

triazole antifungalARO:3007499

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:23495
Label unavailable CHEBI:26878
Label unavailable CHEBI:35727
Label unavailable CHEBI:83403
conazole fungicide CHEBI:87067
triazole fungicide CHEBI:87100
triazole antifungal ARO:3007499

Chemical structure

Computed structure properties
Molecular formula	C17H22ClN3O
Charge	0
Average mass	319.836 Da
Monoisotopic mass	319.14514 Da
Source	ChEBI
InChIKey	XWPZUHJBOLQNMN-UHFFFAOYSA-N

SMILES

CC1(C)CCC(Cc2ccc(Cl)cc2)C1(O)Cn1cncn1

InChI

InChI=1S/C17H22ClN3O/c1-16(2)8-7-14(9-13-3-5-15(18)6-4-13)17(16,22)10-21-12-19-11-20-21/h3-6,11-12,14,22H,7-10H2,1-2H3

Also called

5-(4-chlorobenzyl)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

fungicide CHEBI:24127
antifungal agent CHEBI:35718
EC 1.14.13.70 (sterol 14α-demethylase) inhibitor CHEBI:77884
antifungal agrochemical CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3009302`	metconazole	`antibioticmech:aro-aa9d0683ae`	2026-08-30
CHEBI	`CHEBI:81773`	metconazole	`antibioticmech:chebi-ba4eb6ff77`	2026-08-30

Mechanism summary

Mode of action: ERGOSTEROL_PATHWAY_INHIBITION host shared target — Assigned from ChEBI role CHEBI:75282 (ergosterol biosynthesis inhibitor), CHEBI:77884 (EC 1.14.13.70 (sterol 14α-demethylase) inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Resistance mechanisms

6 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 5

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Aspergillus flavus Cyp51c with mutations conferring resistance to metconazole	ARO:3009491	not organism-specific	—	ARO:3009491 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009302 (metconazole); database assertion, not a primary citation.)
Colletotrichum truncatum cyp51a with mutations associated with resistance to metconazole	ARO:3009214	not organism-specific	—	ARO:3009214 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009302 (metconazole); database assertion, not a primary citation.)
Fusarium graminearum Cyp51A with mutations associated with resistance to metconazole	ARO:3009520	not organism-specific	—	ARO:3009520 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009302 (metconazole); database assertion, not a primary citation.)
Phakospora pachyrhizi Cyp51 with mutations conferring resistance to metconazole	ARO:3009531	not organism-specific	—	ARO:3009531 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009302 (metconazole); database assertion, not a primary citation.)
Pyrenopeziza brassicae Cyp51 with mutations conferring resistance to metconazole	ARO:3009536	not organism-specific	—	ARO:3009536 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009302 (metconazole); database assertion, not a primary citation.)

ANTIBIOTIC_EFFLUX 1

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
Zymoseptoria tritici mfs1 with mutations conferring resistance to metconazole	ARO:3009460	not organism-specific	—	ARO:3009460 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009302 (metconazole); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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