methylparaben

CHEBI:31835 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blueberries. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:85122 CHEBI:85122

Chemical structure

Computed structure properties
Molecular formula	C8H8O3
Charge	0
Average mass	152.149 Da
Monoisotopic mass	152.04734 Da
Source	ChEBI
InChIKey	LXCFILQKKLGQFO-UHFFFAOYSA-N

SMILES

COC(=O)c1ccc(O)cc1

InChI

InChI=1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3

Also called

Maseptol (BRAND_NAME)— chebi
Metaben (BRAND_NAME)— chebi
Methaben (BRAND_NAME)— chebi
Methyl butex (BRAND_NAME)— chebi
Methyl chemosept (BRAND_NAME)— chebi
Metoxyde (BRAND_NAME)— chebi
Moldex (BRAND_NAME)— chebi
Nipagin (BRAND_NAME)— chebi
Paridol (BRAND_NAME)— chebi
Preserval (BRAND_NAME)— chebi
Septos (BRAND_NAME)— chebi
Solbrol (BRAND_NAME)— chebi
Tegosept M (BRAND_NAME)— chebi
methyl 4-hydroxybenzoate (EXACT_SYNONYM)— chebi
4-hydroxybenzoic acid methyl ester (EXACT_SYNONYM)— chebi
E 218 (EXACT_SYNONYM)— chebi
E218 (EXACT_SYNONYM)— chebi
FEMA No. 2710 (EXACT_SYNONYM)— chebi
INS No. 218 (EXACT_SYNONYM)— chebi
INS number 218 (EXACT_SYNONYM)— chebi
Methyl parahydroxybenzoate (EXACT_SYNONYM)— chebi
methyl p-hydroxybenzoate (EXACT_SYNONYM)— chebi
methyl paraben (EXACT_SYNONYM)— chebi
p-Oxybenzoesauremethylester (EXACT_SYNONYM)— chebi
p-carbomethoxyphenol (EXACT_SYNONYM)— chebi
p-hydroxybenzoic acid methyl ester (EXACT_SYNONYM)— chebi
p-methoxycarbonylphenol (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:99-76-3
drugcentral:1766
hmdb:HMDB0032572
kegg.drug:D01400
pdb-ccd:MPB
wikipedia.en:Methylparaben

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:35718 CHEBI:35718
CHEBI:65256 CHEBI:65256

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:31835`	methylparaben	`antibioticmech:chebi-205df798f0`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.