phenamacril
antibioticmech:aro-2c567f176b
·ANTIFUNGAL
·MINTED
SEEDED
Phenamacril is a novel fungicide that has narrow spectrum activity against Fusarium species of fungi. It specifically blocks ATPase activity of myosin motor proteins required for transport of vesicles and organelles within a cell. — PMID:32163521
Machine-generated and unreviewed. Identity, structure and
cross-references come straight from ChEBI's and CARD's own data; no curator has
signed off on this record yet.
Classification
antibiotic without defined classificationARO:3000003
Strictly broader compounds or drug classes this molecule belongs to.
Chemical structure
Computed structure properties
| Molecular formula | C12H12N2O2 |
|---|
| Charge | 0 |
|---|
| Average mass | 216.24 Da |
|---|
| Monoisotopic mass | 216.08987763 Da |
|---|
| Source | PubChem · retrieved 2026-08-29 |
|---|
| InChIKey | YKRQBWKLHCEKQH-UHFFFAOYSA-N |
|---|
SMILES
CCOC(=O)C(=C(C1=CC=CC=C1)N)C#N
InChI
InChI=1S/C12H12N2O2/c1-2-16-12(15)10(8-13)11(14)9-6-4-3-5-7-9/h3-7H,2,14H2,1H3
Cross-references
Equivalent identifiers for this same structure in other resources.
Source concepts
Every upstream concept that resolved to this record. The merge is
the product: this is what shows ChEBI and CARD are describing the same structure.
Upstream concepts merged into this record
| Source | Native ID | Label | Minted CURIE | Version |
|---|
| ARO |
ARO:3009383 |
phenamacril |
antibioticmech:aro-2c567f176b |
2026-08-30 |
Resistance mechanisms
6 known routes by which microbes
resist this compound, grounded in ARO where CARD models them. Grouped by mechanism
type — expand a group to see its determinants.
ANTIBIOTIC_TARGET_ALTERATION 6
ANTIBIOTIC_TARGET_ALTERATION
| Determinant | ARO ID | Organism | Gene families | Evidence |
|---|
| Fusarium asiaticum myosin-5 with mutations conferring resistance against phenamacril |
ARO:3009382 |
not organism-specific |
— |
- ARO:3009382 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
|
| Fusarium fujikuroi myosin-5 with mutations conferring resistance against phenamacril |
ARO:3009386 |
not organism-specific |
— |
- ARO:3009386 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
|
| Fusarium graminearum myosin-5 with mutations conferring resistance against phenamacril |
ARO:3009388 |
not organism-specific |
— |
- ARO:3009388 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
|
| Fusarium incarnatum myosin-5 with mutations conferring resistance against phenamacril |
ARO:3009387 |
not organism-specific |
— |
- ARO:3009387 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
|
| Fusarium oxysporum f.sp. melonis myosin-5 with mutations conferring resistance against phenamacril |
ARO:3009389 |
not organism-specific |
— |
- ARO:3009389 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
|
| Fusarium solani myosin-5 with mutations conferring resistance against phenamacril |
ARO:3009385 |
not organism-specific |
— |
- ARO:3009385 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
|
Curation history
-
SEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
-
RESEEDED_FROM_SOURCES
2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
Provenance
Seeded by scripts/seed_from_sources.py from the committed
inventories in data/raw/.
View the record.