phenamacril

antibioticmech:aro-2c567f176b ·ANTIFUNGAL ·MINTED SEEDED

Phenamacril is a novel fungicide that has narrow spectrum activity against Fusarium species of fungi. It specifically blocks ATPase activity of myosin motor proteins required for transport of vesicles and organelles within a cell. — PMID:32163521

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

antibiotic without defined classificationARO:3000003

Strictly broader compounds or drug classes this molecule belongs to.

antibiotic without defined classification ARO:3000003

Chemical structure

Computed structure properties
Molecular formula	C12H12N2O2
Charge	0
Average mass	216.24 Da
Monoisotopic mass	216.08987763 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	YKRQBWKLHCEKQH-UHFFFAOYSA-N

SMILES

CCOC(=O)C(=C(C1=CC=CC=C1)N)C#N

InChI

InChI=1S/C12H12N2O2/c1-2-16-12(15)10(8-13)11(14)9-6-4-3-5-7-9/h3-7H,2,14H2,1H3

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

phenamacrilARO:3009383
pubchem.compound:66655715

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3009383`	phenamacril	`antibioticmech:aro-2c567f176b`	2026-08-30

Resistance mechanisms

6 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 6

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Fusarium asiaticum myosin-5 with mutations conferring resistance against phenamacril	ARO:3009382	not organism-specific	—	ARO:3009382 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
Fusarium fujikuroi myosin-5 with mutations conferring resistance against phenamacril	ARO:3009386	not organism-specific	—	ARO:3009386 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
Fusarium graminearum myosin-5 with mutations conferring resistance against phenamacril	ARO:3009388	not organism-specific	—	ARO:3009388 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
Fusarium incarnatum myosin-5 with mutations conferring resistance against phenamacril	ARO:3009387	not organism-specific	—	ARO:3009387 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
Fusarium oxysporum f.sp. melonis myosin-5 with mutations conferring resistance against phenamacril	ARO:3009389	not organism-specific	—	ARO:3009389 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)
Fusarium solani myosin-5 with mutations conferring resistance against phenamacril	ARO:3009385	not organism-specific	—	ARO:3009385 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009383 (phenamacril); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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