pyraclostrobin

CHEBI:78780 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A carbamate ester that is the methyl ester of [2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]methoxycarbamic acid. A fungicide used to control major plant pathogens including Septoria tritici, Puccinia spp. and Pyrenophora teres. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

strobilurin fungicideARO:3009305

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:23003 CHEBI:23003
CHEBI:26410 CHEBI:26410
CHEBI:35618 CHEBI:35618
CHEBI:83403 CHEBI:83403
CHEBI:86485 CHEBI:86485
CHEBI:87066 CHEBI:87066
ARO:3009305 ARO:3009305

Chemical structure

Computed structure properties
Molecular formula	C19H18ClN3O4
Charge	0
Average mass	387.823 Da
Monoisotopic mass	387.09858 Da
Source	ChEBI
InChIKey	HZRSNVGNWUDEFX-UHFFFAOYSA-N

SMILES

COC(=O)N(OC)c1ccccc1COc1ccn(-c2ccc(Cl)cc2)n1

InChI

InChI=1S/C19H18ClN3O4/c1-25-19(24)23(26-2)17-6-4-3-5-14(17)13-27-18-11-12-22(21-18)16-9-7-15(20)8-10-16/h3-12H,13H2,1-2H3

Also called

methyl [2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]methoxycarbamate (EXACT_SYNONYM)— chebi
Pyraclostrobine (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3009304
cas:175013-18-0
kegg.compound:C18561
pesticides:pyraclostrobin
ppdb:564
reaxys:10095527
chembl:CHEMBL519873
pubchem.compound:6422843

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:24127 CHEBI:24127
CHEBI:35718 CHEBI:35718
CHEBI:86328 CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3009304`	pyraclostrobin	`antibioticmech:aro-52f6a5d5ae`	2026-08-30
CHEBI	`CHEBI:78780`	pyraclostrobin	`antibioticmech:chebi-f9c5067de2`	2026-08-30

Mechanism summary

Mode of action: ENERGY_METABOLISM_INHIBITION host shared target — Assigned from ChEBI role CHEBI:38499 (mitochondrial cytochrome-bc1 complex inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Resistance mechanisms

3 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 3

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Aspergillus fumigatus Cyp51A with mutations conferring resistance to pyraclostrobin	ARO:3009548	not organism-specific	—	ARO:3009548 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009304 (pyraclostrobin); database assertion, not a primary citation.)
Aspergillus fumigatus beta-tubulin with mutations conferring resistance to pyraclostrobin	ARO:3009479	not organism-specific	—	ARO:3009479 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009304 (pyraclostrobin); database assertion, not a primary citation.)
Colletotrichum gloeosporioides cytochrome b protein with mutations conferring resistance to pyraclostrobin	ARO:3009278	not organism-specific	—	ARO:3009278 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009304 (pyraclostrobin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.