thiabendazole

CHEBI:45979 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

benzimidazole antifungalARO:3009317

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:22715
Label unavailable CHEBI:38418
benzimidazole fungicide CHEBI:87036
benzimidazole antifungal ARO:3009317

Chemical structure

Computed structure properties
Molecular formula	C10H7N3S
Charge	0
Average mass	201.254 Da
Monoisotopic mass	201.03607 Da
Source	ChEBI
InChIKey	WJCNZQLZVWNLKY-UHFFFAOYSA-N

SMILES

c1ccc2nc(-c3cscn3)nc2c1

InChI

InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)

Also called

Equizole (BRAND_NAME)— chebi
Mintezol (BRAND_NAME)— chebi
Thibenzole (BRAND_NAME)— chebi
2-(1,3-thiazol-4-yl)-1H-benzimidazole (EXACT_SYNONYM)— chebi
2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE (EXACT_SYNONYM)— chebi
2-(1,3-thiazol-4-yl)benzimidazole (EXACT_SYNONYM)— chebi
2-(4-thiazolyl)-1H-benzimidazole (EXACT_SYNONYM)— chebi
2-(thiazol-4-yl)benzimidazole (EXACT_SYNONYM)— chebi
4-(2-benzimidazolyl)thiazole (EXACT_SYNONYM)— chebi
MK 360 (EXACT_SYNONYM)— chebi
TBZ (EXACT_SYNONYM)— chebi
Thiabendazole (EXACT_SYNONYM)— chebi
Tiabendazole (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

fungicide CHEBI:24127
antifungal agrochemical CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3009432`	thiabendazole	`antibioticmech:aro-4eb528f7f5`	2026-08-30
CHEBI	`CHEBI:45979`	thiabendazole	`antibioticmech:chebi-ecc41d494a`	2026-08-30

Mechanism summary

Clinical status: APPROVED

Resistance mechanisms

9 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

UNKNOWN 6

UNKNOWN
Determinant	ARO ID	Organism	Gene families	Evidence
benA(E198D) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay
benA(E198K) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay
benA(E198Q) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay
benA(F200Y) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay
benA(H6L) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay
benA(H6Y) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay

ANTIBIOTIC_TARGET_ALTERATION 3

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Colletotrichum gloeosporioides beta tubulin with mutations conferring resistance to thiabendazole	ARO:3009433	not organism-specific	—	ARO:3009433 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009432 (thiabendazole); database assertion, not a primary citation.)
Colletotrichum musae beta-tubulin with mutations conferring resistance to thiabendazole	ARO:3009473	not organism-specific	—	ARO:3009473 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009432 (thiabendazole); database assertion, not a primary citation.)
Fusarium graminearum beta-tubulin with mutations conferring resistance to thiabendazole	ARO:3009431	not organism-specific	—	ARO:3009431 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009432 (thiabendazole); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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