thiabendazole

CHEBI:45979 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

benzimidazole antifungalARO:3009317

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:22715 CHEBI:22715
CHEBI:38418 CHEBI:38418
CHEBI:87036 CHEBI:87036
ARO:3009317 ARO:3009317

Chemical structure

Computed structure properties
Molecular formula	C10H7N3S
Charge	0
Average mass	201.254 Da
Monoisotopic mass	201.03607 Da
Source	ChEBI
InChIKey	WJCNZQLZVWNLKY-UHFFFAOYSA-N

SMILES

c1ccc2nc(-c3cscn3)nc2c1

InChI

InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)

Also called

Equizole (BRAND_NAME)— chebi
Mintezol (BRAND_NAME)— chebi
Thibenzole (BRAND_NAME)— chebi
2-(1,3-thiazol-4-yl)-1H-benzimidazole (EXACT_SYNONYM)— chebi
2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE (EXACT_SYNONYM)— chebi
2-(1,3-thiazol-4-yl)benzimidazole (EXACT_SYNONYM)— chebi
2-(4-thiazolyl)-1H-benzimidazole (EXACT_SYNONYM)— chebi
2-(thiazol-4-yl)benzimidazole (EXACT_SYNONYM)— chebi
4-(2-benzimidazolyl)thiazole (EXACT_SYNONYM)— chebi
MK 360 (EXACT_SYNONYM)— chebi
TBZ (EXACT_SYNONYM)— chebi
Thiabendazole (EXACT_SYNONYM)— chebi
Tiabendazole (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3009432
beilstein:611403
cas:148-79-8
drugbank:DB00730
drugcentral:2621
hmdb:HMDB0014868
kegg.drug:D00372
lincs.smallmolecule:LSM-3741
metacyc.compound:THIABENDAZOLE
patent:US3017415
pdb-ccd:TMG
pesticides:thiabendazole
ppdb:629
reaxys:611403
vsdb:629
wikipedia.en:Thiabendazole
chembl:CHEMBL625
pubchem.compound:5430

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:24127 CHEBI:24127
CHEBI:86328 CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3009432`	thiabendazole	`antibioticmech:aro-4eb528f7f5`	2026-08-30
CHEBI	`CHEBI:45979`	thiabendazole	`antibioticmech:chebi-ecc41d494a`	2026-08-30

Mechanism summary

Clinical status: APPROVED

Resistance mechanisms

9 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

UNKNOWN 6

UNKNOWN
Determinant	ARO ID	Organism	Gene families	Evidence
benA(E198D) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay
benA(E198K) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay
benA(E198Q) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay
benA(F200Y) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay
benA(H6L) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay
benA(H6Y) (amino acid mutation) [Not assayed] associated with resistance to thiabendazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus nidulans `NCBITaxon:162425` strain G191 `NCBITaxon:227321` `UniProtKB:P10653` CBF87981 `PHIPO:0000673`	—	PMID:1423663 (PHI-base primary-literature antimicrobial interaction PHIG:833; joined to this record by exact ChEBI identifier.) Cell growth assay

ANTIBIOTIC_TARGET_ALTERATION 3

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Colletotrichum gloeosporioides beta tubulin with mutations conferring resistance to thiabendazole	ARO:3009433	not organism-specific	—	ARO:3009433 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009432 (thiabendazole); database assertion, not a primary citation.)
Colletotrichum musae beta-tubulin with mutations conferring resistance to thiabendazole	ARO:3009473	not organism-specific	—	ARO:3009473 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009432 (thiabendazole); database assertion, not a primary citation.)
Fusarium graminearum beta-tubulin with mutations conferring resistance to thiabendazole	ARO:3009431	not organism-specific	—	ARO:3009431 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009432 (thiabendazole); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.