tolclofos-methyl

CHEBI:81731 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for controlling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:23697 CHEBI:23697
CHEBI:37512 CHEBI:37512

Chemical structure

Computed structure properties
Molecular formula	C9H11Cl2O3PS
Charge	0
Average mass	301.131 Da
Monoisotopic mass	299.95436 Da
Source	ChEBI
InChIKey	OBZIQQJJIKNWNO-UHFFFAOYSA-N

SMILES

COP(=S)(OC)Oc1c(Cl)cc(C)cc1Cl

InChI

InChI=1S/C9H11Cl2O3PS/c1-6-4-7(10)9(8(11)5-6)14-15(16,12-2)13-3/h4-5H,1-3H3

Also called

Basilex (BRAND_NAME)— chebi
Grancer (BRAND_NAME)— chebi
Risolex (BRAND_NAME)— chebi
Rizolex (BRAND_NAME)— chebi
O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl phosphorothioate (EXACT_SYNONYM)— chebi
O-(2,6-dichloro-4-methylphenyl)phosphorothioic acid O,O-dimethyl ester (EXACT_SYNONYM)— chebi
O-2,6-dichloro-p-tolyl O,O-dimethyl phosphorothioate (EXACT_SYNONYM)— chebi
S-3349 (EXACT_SYNONYM)— chebi
tolclofos-Me (EXACT_SYNONYM)— chebi
tolclofos-méthyl (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:57018-04-9
kegg.compound:C18407
patent:DE2501040
patent:GB1467561
pesticides:tolclofos-methyl
ppdb:644
reaxys:2136521

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:86328 CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:81731`	tolclofos-methyl	`antibioticmech:chebi-7fc74626e3`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.