triforine

CHEBI:9715 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A member of the class of N-alkylpiperazines in which the two amino groups of piperazine are replaced by 1-formamido-2,2,2-trichloroethyl groups. A fungicide active against a range of diseases including powdery mildew, scab and rust. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:24079
Label unavailable CHEBI:36683
Label unavailable CHEBI:46845
amide fungicide CHEBI:60600

Chemical structure

Computed structure properties
Molecular formula	C10H14Cl6N4O2
Charge	0
Average mass	434.966 Da
Monoisotopic mass	431.92479 Da
Source	ChEBI
InChIKey	RROQIUMZODEXOR-UHFFFAOYSA-N

SMILES

[H]C(=O)NC(N1CCN(C(NC([H])=O)C(Cl)(Cl)Cl)CC1)C(Cl)(Cl)Cl

InChI

InChI=1S/C10H14Cl6N4O2/c11-9(12,13)7(17-5-21)19-1-2-20(4-3-19)8(18-6-22)10(14,15)16/h5-8H,1-4H2,(H,17,21)(H,18,22)

Also called

Funginex (BRAND_NAME)— chebi
N,N'-[piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl)]diformamide (EXACT_SYNONYM)— chebi
1,4-Bis(1-formamido-2,2,2-trichloroethyl)piperazine (EXACT_SYNONYM)— chebi
1,4-Bis(2,2,2-trichloro-1-formamidoethyl)piperazine (EXACT_SYNONYM)— chebi
Biformylchlorazin (EXACT_SYNONYM)— chebi
N,N'-(1,4-Piperazinediylbis(2,2,2-trichloroethylidene))bisformamide (EXACT_SYNONYM)— chebi
N,N'-(Piperazine-1,4-diylbis((trichloromethyl)methylene))diformamide (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

fungicide CHEBI:24127
antifungal agent CHEBI:35718
EC 1.14.13.70 (sterol 14α-demethylase) inhibitor CHEBI:77884
antifungal agrochemical CHEBI:86328

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:9715`	triforine	`antibioticmech:chebi-140e97f4e4`	2026-08-30

Mechanism summary

Mode of action: ERGOSTEROL_PATHWAY_INHIBITION host shared target — Assigned from ChEBI role CHEBI:77884 (EC 1.14.13.70 (sterol 14α-demethylase) inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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