voriconazole

CHEBI:10023 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

triazole antifungalARO:3007499

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:26878
Label unavailable CHEBI:38582
Label unavailable CHEBI:39447
conazole antifungal drug CHEBI:87071
triazole antifungal drug CHEBI:87101
triazole antifungal ARO:3007499

Chemical structure

Computed structure properties
Molecular formula	C16H14F3N5O
Charge	0
Average mass	349.316 Da
Monoisotopic mass	349.11504 Da
Source	ChEBI
InChIKey	BCEHBSKCWLPMDN-MGPLVRAMSA-N

SMILES

C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F

InChI

InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1

Also called

Vfend (BRAND_NAME)— chebi
voriconazol (INN)— chebi
voriconazolum (INN)— chebi
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (EXACT_SYNONYM)— chebi
(R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (EXACT_SYNONYM)— chebi
(αR,βS)-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (EXACT_SYNONYM)— chebi
VCZ (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antifungal agent CHEBI:35718
antifungal drug CHEBI:86327

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3007512`	voriconazole	`antibioticmech:aro-7c51b80ef5`	2026-08-30
CHEBI	`CHEBI:10023`	voriconazole	`antibioticmech:chebi-35a61b95ae`	2026-08-30

Mechanism summary

Mode of action: ERGOSTEROL_PATHWAY_INHIBITION host shared target — Assigned from ChEBI role CHEBI:75282 (ergosterol biosynthesis inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.
Clinical status: APPROVED

Activity spectrum

Measured or curated activity against specific taxa. A number without a method is not an observation — every row here carries an assay.

3 observations · Browse all observations · Complete record (JSON.gz)

Activity observations
Organism	Activity	MIC	Disk diffusion	Assay	Strain	Sample/genome	Evidence
Aspergillus flavus NCBITaxon:5059	RESISTANT	8.0 mg/L	—	CLSI M38-A2 broth microdilution	BMU29791	—	Evidence Page data (JSON.gz)
Candida albicans NCBITaxon:5476	—	<0.0078 mg/L	—	EUCAST broth microdilution, source RPMI 1640 condition	JEY355	—	Evidence Page data (JSON.gz)
Candida tropicalis NCBITaxon:5482	RESISTANT	>16.0 mg/L	—	EUCAST broth microdilution, source RPMI 1640 condition	JEY162	—	Evidence Page data (JSON.gz)

Resistance mechanisms

62 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 31

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Aspergillus flavus Cyp51B with mutations conferring resistance to voriconazole	ARO:3009485	not organism-specific	—	ARO:3009485 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus flavus Cyp51a with mutations conferring resistance to voriconazole	ARO:3009498	not organism-specific	—	ARO:3009498 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus flavus Cyp51c with mutations conferring resistance to voriconazole	ARO:3009283	not organism-specific	—	ARO:3009283 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus Cyp51B with mutations conferring resistance to voriconazole	ARO:3009483	not organism-specific	—	ARO:3009483 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus Cyp51a with mutations conferring resistance to voriconazole	ARO:3009503	not organism-specific	—	ARO:3009503 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus Hmg1 with mutations conferring resistance to voriconazole	ARO:3009235	not organism-specific	—	ARO:3009235 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus Hmg2 with mutations conferring resistance to voriconazole	ARO:3009369	not organism-specific	—	ARO:3009369 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus ase1 with mutations conferring resistance to voriconazole	ARO:3009274	not organism-specific	—	ARO:3009274 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus cyp51a with mutations conferring resistance to voriconazole	ARO:3009201	not organism-specific	—	ARO:3009201 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus niger Cyp51a with mutations conferring resistance to voriconazole	ARO:3009508	not organism-specific	—	ARO:3009508 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus spp. Hmg1 with mutations conferring resistance to triazoles antibiotics	ARO:3007670	not organism-specific	—	ARO:3007670 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus spp. cyp51A with mutations conferring resistance to triazoles antibiotics	ARO:3007565	not organism-specific	—	ARO:3007565 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus terreus cyp51a with mutations conferring resistance to voriconazole	ARO:3009205	not organism-specific	—	ARO:3009205 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida albicans Cyp51 with mutations conferring resistance to voriconazole	ARO:3009526	not organism-specific	—	ARO:3009526 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida albicans Erg11 with mutations conferring resistance to voriconazole	ARO:3009415	not organism-specific	—	ARO:3009415 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida auris Erg11 lanosterol 14-alpha-demethylase with mutations associated with resistance to voriconazole	ARO:3009221	not organism-specific	—	ARO:3009221 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida auris FKS1 beta-1,3-glucan synthase with mutations conferring resistance to voriconazole	ARO:3009613	not organism-specific	—	ARO:3009613 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida orthopsilosis ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole	ARO:3009581	not organism-specific	—	ARO:3009581 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida parapsilosis Erg11 lanosterol 14-alpha-demethylase with mutations associated with resistance to voriconazole	ARO:3009582	not organism-specific	—	ARO:3009582 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida parapsilosis Erg3 C-5 sterol desaturase with mutations conferring resistance to itraconazole	ARO:3009243	not organism-specific	—	ARO:3009243 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida parapsilosis Erg3 C-5 sterol desaturase with mutations conferring resistance to voriconazole	ARO:3009245	not organism-specific	—	ARO:3009245 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida spp. ERG11 with mutations conferring resistance to azole antibiotics	ARO:3007524	not organism-specific	—	ARO:3007524 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida tropicalis Erg11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole	ARO:3009227	not organism-specific	—	ARO:3009227 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Colletotrichum truncatum cyp51a with mutations associated with resistance to voriconazole	ARO:3009218	not organism-specific	—	ARO:3009218 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Cryptococcus neoformans Erg11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole	ARO:3009229	not organism-specific	—	ARO:3009229 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Histoplasma capsulatum Erg11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole	ARO:3009223	not organism-specific	—	ARO:3009223 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Nakaseomyces glabratus FKS1 beta-1,3-glucan synthase with mutations associated with resistance to voriconazole	ARO:3009616	not organism-specific	—	ARO:3009616 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Nakaseomyces glabratus FKS2 beta-1,3-glucan synthase with mutations associated with resistance to voriconazole	ARO:3009620	not organism-specific	—	ARO:3009620 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Pichia kudriavzevii ERG11 with mutations conferring resistance to voriconazole	ARO:3009399	not organism-specific	—	ARO:3009399 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Saccharomyces cerevisiae ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole	ARO:3009591	not organism-specific	—	ARO:3009591 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
antifungal resistance-associated MSH	ARO:3009134	not organism-specific	—	ARO:3009134 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)

UNKNOWN 24

UNKNOWN
Determinant	ARO ID	Organism	Gene families	Evidence
CYP51A transformant(CM2627-CYP51Apromoter(2x34bp tandem repeat) and CM2627-CYP51A(L98H)) (transformant) [Overexpression] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review mellado-2007-fumigatus-reference-context: The strain label denotes a parent background, not an individual tested derivative or clinical donor. UniProtKB:Q4WNT5 and the retained gene_id denote the Af293 reference locus; TaxID 330879 is reference-only. The combined source alteration remains intact, without assigning its effect to each component. Source phenotypes are unchanged; exact subject protein, strain TaxID and genome remain unresolved. Reference-only source identifiers: strain_taxon_id=NCBITaxon:330879; protein_accession=UniProtKB:Q4WNT5.	—	Aspergillus fumigatus `NCBITaxon:746128` strain CM237 Afu4g06890-T `PHIPO:0000590`	—	PMID:17371828 (PHI-base primary-literature antimicrobial interaction PHIG:1837; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.01092-06 (Identifier-scope review: Results: clinical isolates and separate recipient backgrounds, Table 4 and its subject-identity footnote, UniProtKB release 2026_03: Q4WNT5 entry 146, sequence version 1; EnsemblFungi cross-reference and reference taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
Candida albicans TAC1 with mutations conferring resistance to voriconazole	ARO:3009429	not organism-specific	—	ARO:3009429 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Clinical ERG3 association with voriconazole resistance Same-isolate genotype-phenotype co-occurrence, not independent causality for this component of the reported combined ERG3/ERG11 genotype. Source alteration notation retained; no reference-coordinate equivalence or laboratory-derivative identity inferred.	—	Candida tropicalis `NCBITaxon:5482` strain JEY162 `UniProtKB:N0A5G3`	ERG3	PMID:23629718 (Results: clinical susceptibility and CtERG3 sequence analysis; Table 3. The genotype and measured phenotype share the named clinical isolate. Laboratory functional evidence remains separate.) UniProtKB:N0A5G3 (Release 2026_03, entry version 42, sequence version 1, inspected 2026-10-08. Paper-declared deposit KC676662 / AGK44786.1 has protein-specific JEY162 strain evidence in citation CI-DK7KGAGGARC54. That citation has no indexed PMID; linkage uses the declared accession and strain, not bibliography alone. A different reference's ATCC strain label is not transferred.)
ERG11 transformant(JEY162-ERG11(824-955bpdelta + D275V) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review eddouzi-2013-erg11-reference-context: UniProtKB:P14263 and the retained gene_id identify a reference ERG11 locus, not the deposited clinical allele or tested derivative. The imported subject label remains unresolved. Source notation, compound-specific phenotype and species are retained without coordinate normalization, subject reassignment or independent attribution of combined-genotype effects. Reference-only source identifiers: protein_accession=UniProtKB:P14263.	—	Candida tropicalis `NCBITaxon:5482` strain 1909 CTRG_05283-t43_1 `PHIPO:0000590`	—	PMID:23629718 (PHI-base primary-literature antimicrobial interaction PHIG:8774; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.00555-13 (Identifier-scope review: Results, Tables 1 and 3, UniProtKB release 2026_03: P14263 entry 126, sequence version 2; EnsemblFungi cross-reference. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
ERG11 transformant(MRL862-ERG11(Y145F)) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review sionov-2012-parent-and-deposit-context: H99 is the parent/reference background, distinct from the clinical isolate and tested derivatives. Q870D1 has species-level taxonomy and a deposit cross-reference different from those reported in this paper; it does not resolve an exact subject allele. Source biological fields remain unchanged. No replacement protein, strain TaxID, genome or measurement is inferred. Reference-only source identifiers: protein_accession=UniProtKB:Q870D1.	—	Cryptococcus neoformans `NCBITaxon:5207` strain H99 `PHIPO:0000590`	—	PMID:22155829 (PHI-base primary-literature antimicrobial interaction PHIG:1668; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.05502-11 (Identifier-scope review: Results and Discussion, Table 1: reference parent, clinical isolate and tested derivatives, Nucleotide accession statement: paper deposits differ from the imported entry cross-reference, UniProtKB release 2026_03: Q870D1 entry 121, sequence version 1; species taxonomy and EMBL cross-reference. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
ERG11(Y132F F145L) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review flowers-2015-reference-context: The strain label denotes the susceptible parent background, not either tested replicate or a clinical donor. UniProtKB:P10613 and the retained gene_id identify the reference ERG11 locus, not an exact experimental allele. Deposited clinical-source proteins are separate evidence; no isolate join, coordinate normalization or attribution of a combined genotype's effect to each component is inferred. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:P10613.	—	Candida albicans `NCBITaxon:5476` strain SC5314 C5_00660C_A-T `PHIPO:0000590`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.03470-14 (Identifier-scope review: Table 1, Results and Figure 2, Table 3: separate clinical cohort, UniProtKB release 2026_03: P10613 entry 179, sequence version 2; EnsemblFungi cross-reference. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
ERG11(Y132F K143R) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review flowers-2015-reference-context: The strain label denotes the susceptible parent background, not either tested replicate or a clinical donor. UniProtKB:P10613 and the retained gene_id identify the reference ERG11 locus, not an exact experimental allele. Deposited clinical-source proteins are separate evidence; no isolate join, coordinate normalization or attribution of a combined genotype's effect to each component is inferred. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:P10613.	—	Candida albicans `NCBITaxon:5476` strain SC5314 C5_00660C_A-T `PHIPO:0000590`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.03470-14 (Identifier-scope review: Table 1, Results and Figure 2, Table 3: separate clinical cohort, UniProtKB release 2026_03: P10613 entry 179, sequence version 2; EnsemblFungi cross-reference. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
ERG3 transformant(JEY162-ERG3(S258F)) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review eddouzi-2013-erg3-donor-context: UniProtKB:N0A5G3 explicitly links the clinical donor JEY162 deposit KC676662 / AGK44786.1, not the imported subject label, which remains unresolved. Clinical, heterologous-host and native-derivative observations remain distinct; combined-genotype effects are not attributed independently to this component. Reference-only source identifiers: protein_accession=UniProtKB:N0A5G3.	—	Candida tropicalis `NCBITaxon:5482` strain 1909 `PHIPO:0000590`	—	PMID:23629718 (PHI-base primary-literature antimicrobial interaction PHIG:8773; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.00555-13 (Identifier-scope review: Results: clinical and laboratory subjects, Tables 1 and 3, Declared deposits, UniProtKB release 2026_03: N0A5G3 entry 42, sequence version 1; KC676662 / AGK44786.1 strain evidence. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
ERG3delta (deletion) associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review rybak-2017-albicans-reference-context: The retained strain label is parent background, not the tested deletion derivative. UniProtKB:Q59VG6 and the retained gene_id ground the reference ERG3 locus. Reference protein and strain TaxID are not derivative identifiers. Native clinical-isolate and laboratory observations remain separate; no MIC or exact derivative identifier is inferred. Reference-only source identifiers: strain_taxon_id=NCBITaxon:237561; protein_accession=UniProtKB:Q59VG6.	—	Candida albicans `NCBITaxon:5476` strain SC5314 C1_04770C_A-T `PHIPO:0000590`	—	PMID:28630186 (PHI-base primary-literature antimicrobial interaction PHIG:1133; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.00651-17 (Identifier-scope review: Results: ERG3 disruption comparisons, Strain table: parent and derivative rows, UniProtKB release 2026_03: Q59VG6 entry 109, sequence version 1; EnsemblFungi cross-reference. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
ERG3delta (deletion) associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review rybak-2017-parapsilosis-reference-context: UniProtKB:G8B7T4 / CPAR2_105550 and strain TaxID 578454 identify CDC 317 reference context, not a clinical isolate or tested derivative. The source row does not uniquely resolve either tested background. Its deletion claim is not the native clinical variant; no individual isolate, clinical protein, genome or MIC is assigned. Reference-only source identifiers: strain_taxon_id=NCBITaxon:578454; protein_accession=UniProtKB:G8B7T4.	—	Candida parapsilosis `NCBITaxon:5480` strain Unknown strain `PHIPO:0000590`	—	PMID:28630186 (PHI-base primary-literature antimicrobial interaction PHIG:8772; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.00651-17 (Identifier-scope review: Results: clinical isolates and ERG3 disruption comparisons, Strain table: two clinical backgrounds and their derivatives, UniProtKB release 2026_03: G8B7T4 entry 50, sequence version 1; EMBL and CGD cross-references. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
HapE transformant(Isolate3-HapE(P88L)) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review camps-2012-fumigatus-reference-context: The strain label denotes a parent background, not either later tested replicate or the native clinical isolate. UniProtKB:Q4WDM9 / AFUA_6G05300 and TaxID 330879 denote Af293 reference context. Reference-guided sequence analysis does not identify a clinical or experimental subject as Af293. Source alterations and phenotypes are unchanged; exact subject protein, strain TaxID and genome remain unresolved. Reference-only source identifiers: strain_taxon_id=NCBITaxon:330879; protein_accession=UniProtKB:Q4WDM9.	—	Aspergillus fumigatus `NCBITaxon:746128` strain akuBKU80 `PHIPO:0000590`	—	PMID:23226235 (PHI-base primary-literature antimicrobial interaction PHIG:8691; joined to this record by exact ChEBI identifier.) DOI:10.1371/journal.pone.0050034 (Identifier-scope review: Results sections s3a-s3b: clinical series and reference genomes, Results section s3d and Table 7: later experimental groups, UniProtKB release 2026_03: Q4WDM9 entry 125, sequence version 1; AFUA_6G05300 reference crosswalk and taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
cox10 transformant(W004-cox10(R243Q)) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review wei-2016-reference-context-followup: The source strain label denotes a parent background, not an individual tested derivative. Af293 and A1163/CEA10 UniProt entries and strain TaxIDs describe reference context. The retained gene_id is a reference-locus identifier, not an experimental allele. Increased frequency of later colonies is distinct from baseline susceptibility, and plate growth is not a broth MIC or a clinical resistance category. These endpoint distinctions remain review limitations, not new activity observations. Source alterations, phenotypes and assays are unchanged; exact subject protein, strain TaxID and genome remain unresolved. Reference-only source identifiers: strain_taxon_id=NCBITaxon:451804; protein_accession=UniProtKB:B0Y628.	—	Aspergillus fumigatus `NCBITaxon:746128` strain A1160C `PHIPO:0000590`	—	PMID:27799210 (PHI-base primary-literature antimicrobial interaction PHIG:8689; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.02101-16 (Identifier-scope review: Results and Figures 1-4: baseline parent versus separate tested groups, Tables 1-2: subject identity and distinct assay endpoints, UniProtKB release 2026_03: Q4WNT5 entry 146; B0XYD8 entry 86; B0Y628 entry 66; all sequence version 1; reference taxonomy. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
cyp51A transformant(F33-cyp51A (G448S)) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain F55064 `NCBITaxon:330879` `UniProtKB:Q4WNT5` Afu4g06890-T `PHIPO:0000590`	—	PMID:22897872 (PHI-base primary-literature antimicrobial interaction PHIG:1837; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A(G448S) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain H27023 `NCBITaxon:330879` `UniProtKB:Q4WNT5` Afu4g06890-T `PHIPO:0000590`	—	PMID:22897872 (PHI-base primary-literature antimicrobial interaction PHIG:1837; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A(G448S) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain W73355 `NCBITaxon:330879` `UniProtKB:Q4WNT5` Afu4g06890-T `PHIPO:0000590`	—	PMID:22897872 (PHI-base primary-literature antimicrobial interaction PHIG:1837; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A(G448S) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain F55064 `NCBITaxon:330879` `UniProtKB:Q4WNT5` Afu4g06890-T `PHIPO:0000590`	—	PMID:22897872 (PHI-base primary-literature antimicrobial interaction PHIG:1837; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A(K197N) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review krishnan-natesan-2008-reference-context: The strain label denotes the susceptible parent, not the resistant isolate. NRRL 3357 identifiers are reference-only; source coordinates remain unnormalized. Reference-only source identifiers: strain_taxon_id=NCBITaxon:332952; protein_accession=UniProtKB:B8N2C8.	—	Aspergillus flavus `NCBITaxon:5059` strain X26728 AFLA_001488_t1 `PHIPO:0000590`	—	PMID:18775650 (PHI-base primary-literature antimicrobial interaction PHIG:338; joined to this record by exact ChEBI identifier.) DOI:10.1016/j.ijantimicag.2008.06.018 (Identifier-scope review: Table 1, Section 3.1, Discussion. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
cyp51A(K197N, D282E, M288L) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review krishnan-natesan-2008-reference-context: The strain label denotes the susceptible parent, not the resistant isolate. NRRL 3357 identifiers are reference-only; source coordinates remain unnormalized. Reference-only source identifiers: strain_taxon_id=NCBITaxon:332952; protein_accession=UniProtKB:B8N2C8.	—	Aspergillus flavus `NCBITaxon:5059` strain X26728 AFLA_001488_t1 `PHIPO:0000590`	—	PMID:18775650 (PHI-base primary-literature antimicrobial interaction PHIG:338; joined to this record by exact ChEBI identifier.) DOI:10.1016/j.ijantimicag.2008.06.018 (Identifier-scope review: Table 1, Section 3.1, Discussion. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
cyp51A(Y132N, T469S) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review krishnan-natesan-2008-reference-context: The strain label denotes the susceptible parent, not the resistant isolate. NRRL 3357 identifiers are reference-only; source coordinates remain unnormalized. Reference-only source identifiers: strain_taxon_id=NCBITaxon:332952; protein_accession=UniProtKB:B8N2C8.	—	Aspergillus flavus `NCBITaxon:5059` strain X26728 AFLA_001488_t1 `PHIPO:0000590`	—	PMID:18775650 (PHI-base primary-literature antimicrobial interaction PHIG:338; joined to this record by exact ChEBI identifier.) DOI:10.1016/j.ijantimicag.2008.06.018 (Identifier-scope review: Table 1, Section 3.1, Discussion. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
cyp51A+ (wild type) [Overexpression] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review liu-2012-cyp51a-subject-context: AF-A is the tested derivative, not clinical isolate BMU29791. NRRL 3357 is reference/donor context. UniProtKB:B8N2C8 and the retained gene_id ground a reference locus, not an independently resolved experimental protein accession. Original source background label: NRRL 3357. Reference-only source identifiers: strain_taxon_id=NCBITaxon:332952; protein_accession=UniProtKB:B8N2C8.	—	Aspergillus flavus `NCBITaxon:5059` strain AF-A AFLA_001488_t1 `PHIPO:0000590`	—	PMID:22314539 (PHI-base primary-literature antimicrobial interaction PHIG:338; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.05477-11 (Identifier-scope review: Table 2, Results: expression-level comparison, UniProtKB release 2026_03: B8N2C8 entry 90, sequence version 1. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
cyp51B(H399P, D411N) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review krishnan-natesan-2008-reference-context: The strain label denotes the susceptible parent, not the resistant isolate. NRRL 3357 identifiers are reference-only; source coordinates remain unnormalized. Reference-only source identifiers: strain_taxon_id=NCBITaxon:332952; protein_accession=UniProtKB:B8NFL5.	—	Aspergillus flavus `NCBITaxon:5059` strain X26728 AFLA_005443_t1 `PHIPO:0000590`	—	PMID:18775650 (PHI-base primary-literature antimicrobial interaction PHIG:336; joined to this record by exact ChEBI identifier.) DOI:10.1016/j.ijantimicag.2008.06.018 (Identifier-scope review: Table 1, Section 3.1, Discussion. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
cyp51B(T454P, T486P) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review krishnan-natesan-2008-reference-context: The strain label denotes the susceptible parent, not the resistant isolate. NRRL 3357 identifiers are reference-only; source coordinates remain unnormalized. Reference-only source identifiers: strain_taxon_id=NCBITaxon:332952; protein_accession=UniProtKB:B8NFL5.	—	Aspergillus flavus `NCBITaxon:5059` strain X26728 AFLA_005443_t1 `PHIPO:0000590`	—	PMID:18775650 (PHI-base primary-literature antimicrobial interaction PHIG:336; joined to this record by exact ChEBI identifier.) DOI:10.1016/j.ijantimicag.2008.06.018 (Identifier-scope review: Table 1, Section 3.1, Discussion. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
cyp51B+ (wild type) [Overexpression] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review liu-2012-cyp51b-subject-context: AF-B is the tested derivative, not clinical isolate BMU29791. NRRL 3357 is reference/donor context. UniProtKB:B8NFL5 and the retained gene_id ground a reference locus, not a verified historical experimental protein sequence. Original source background label: NRRL 3357. Reference-only source identifiers: strain_taxon_id=NCBITaxon:332952; protein_accession=UniProtKB:B8NFL5.	—	Aspergillus flavus `NCBITaxon:5059` strain AF-B AFLA_005443_t1 `PHIPO:0000590`	—	PMID:22314539 (PHI-base primary-literature antimicrobial interaction PHIG:336; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.05477-11 (Identifier-scope review: Table 2, Results: expression-level comparison, UniProtKB release 2026_03: B8NFL5 entry 92, sequence version 3. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay
cyp51C-T788G(S240A) (amino acid mutation) [Wild type product level] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism. Grounding review liu-2012-cyp51c-subject-context: AflavC-788 is the tested derivative, not clinical isolate BMU29791. UniProtKB:B8NUK6 supports the cited reference-protein feature, not an isolate-specific accession. The retained gene_id denotes the reference locus; source coordinates remain unnormalized. Original source background label: NRRL 3357. Reference-only source identifiers: strain_taxon_id=NCBITaxon:332952; protein_accession=UniProtKB:B8NUK6.	—	Aspergillus flavus `NCBITaxon:5059` strain AflavC-788 AFLA_010303_t1 `PHIPO:0000590`	—	PMID:22314539 (PHI-base primary-literature antimicrobial interaction PHIG:337; joined to this record by exact ChEBI identifier.) DOI:10.1128/aac.05477-11 (Identifier-scope review: Table 2, Results: cyp51C variant comparison, UniProtKB release 2026_03: B8NUK6 entry 87, sequence version 1; PMID 22314539 feature. Reviewed 2026-10-08 by codex; curation/phibase_grounding_reviews.json SHA-256 1f5d50346b2916fce10969afa8d6409ea836dd15e8cf7fe3cfa3a78d6289b4ed.) Cell growth assay

ANTIBIOTIC_EFFLUX 7

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
Aspergillus flavus MFS1 with mutations conferring resistance to voriconazole	ARO:3009458	not organism-specific	—	ARO:3009458 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus flavus Mdr2 with mutations conferring resistance to voriconazole	ARO:3009451	not organism-specific	—	ARO:3009451 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mdr1 with mutations associated with resistance to voriconazole	ARO:3009252	not organism-specific	—	ARO:3009252 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mdr3 with mutations associated with resistance to voriconazole	ARO:3009257	not organism-specific	—	ARO:3009257 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mfs1 with mutations associated with resistance to voriconazole	ARO:3009265	not organism-specific	—	ARO:3009265 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mfs2 with mutations associated with resistance to voriconazole	ARO:3009267	not organism-specific	—	ARO:3009267 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
fungal MDR	ARO:3009425	not organism-specific	—	ARO:3009425 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
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RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources
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RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources
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RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories
REVIEWED_RESISTANCE_IDENTIFIER_SCOPE 2026-10-08 · codex · LLM-assisted
Applied pinned PHI-base identifier-scope review to five associations; withheld reference-only protein and strain identifiers without replacing source claims.
REVIEWED_RESISTANCE_IDENTIFIER_SCOPE 2026-10-08 · codex · LLM-assisted
Refreshed the whole-file PHI-base review checksum after an additional review; all biological fields and previous identifier-scope decisions unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Resolved three PHI-base tested-derivative labels, retained reference-only UniProt grounding, withheld parent strain/protein identity, and added one independently reported clinical-isolate MIC with its historical source interpretation. Refreshed review checksums without changing prior decisions.
REVIEWED_RESISTANCE_IDENTIFIER_SCOPE 2026-10-08 · codex · LLM-assisted
Refreshed the whole-file PHI-base review checksum after the FKS1 review; all biological fields and previous identifier-scope decisions unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Applied 2 pinned subject-context reviews, retaining reference-locus grounding while withholding unverified experimental protein/strain identifiers. Source alterations, phenotypes, species, genes, and existing activities unchanged. Refreshed provenance checksums on any previously reviewed claims. ERG11 parent, replicate and clinical-donor contexts remain separate.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Scoped 2 imported associations without conflating reference, donor and unresolved tested-subject identities. Preserved source alterations and phenotypes; refreshed older review checksums without biological changes. Added two independently reported clinical MICs in mg/L, preserving qualifiers and historical interpretation, and one deposit-grounded ERG3 same-isolate association without independent component causality.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Scoped two imported ERG3 associations: reference proteins and strain TaxIDs are not experimental-subject identifiers. Retained source species, background labels, alterations and phenotypes; clinical isolates remain separate. Existing activities and curator claims unchanged; refreshed older review checksums.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed the whole-file PHI-base review checksum after carboxin reference-context reviews; all biological fields, activities and previous decisions unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed the whole-file PHI-base review checksum after two additional carboxin identifier-scope corrections; all biological fields, activities and previous decisions unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed the whole-file PHI-base review checksum after eleven additional identifier-scope corrections; biological fields, activities and decisions unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Scoped imported associations to the reported parent background: Af293 reference protein and strain TaxID are not tested-subject identities. Source alterations, phenotypes, assays and clinical activities unchanged; no exact allele or genome inferred.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed the whole-file PHI-base review checksum after one yeast identity-scope correction; biological fields, activities and prior decisions unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Scoped imported reference protein and strain TaxID to provenance, not tested-subject identity. Source parent labels, alterations, phenotypes and assays preserved; no experimental allele, genome or activity measurement inferred.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Scoped source protein and reference-strain identifiers to provenance, not exact experimental subjects, after primary-paper review. Parent labels and source biological fields preserved; no new allele, measurement or genome inferred.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed the shared PHI-base review checksum after six identifier-scope corrections; previous decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed the shared PHI-base review checksum after eight subject-identity corrections; previous decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the Darlington subject correction; prior review decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the Nakayama reference-scope review; prior decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the Duan reference-scope review; prior decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the Piotrowska parent-reference review; prior decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the Xu subject and species corrections; prior decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the Shima parent-reference review; prior decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the Mehrabi parent-reference review; prior decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-08 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the Huang parent-reference review; prior decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-09 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the HDF1 subject-reference review; prior decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-09 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the Fouche parent-cohort review; prior decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_REFERENCE_CONTEXT 2026-10-09 · codex · LLM-assisted
Refreshed shared PHI-base review checksum after the SDH8 reference-alias correction; prior decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-09 · codex · LLM-assisted
Refreshed the shared PHI-base review checksum after the Posteraro subject-context review; previous decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_REFERENCE_CONTEXT 2026-10-12 · codex · LLM-assisted
Refreshed the shared PHI-base review checksum after four reference-identifier scope corrections; previous decisions, biological fields and activities unchanged.
REVIEWED_RESISTANCE_SUBJECT_CONTEXT 2026-10-13 · codex · LLM-assisted
Refreshed the shared PHI-base review checksum after one Neurospora subject-context correction; previous decisions, biological fields and activities unchanged.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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