voriconazole

CHEBI:10023 ·resolve ·ANTIFUNGAL ·EXACT SEEDED

A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

triazole antifungalARO:3007499

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:26878 CHEBI:26878
CHEBI:38582 CHEBI:38582
CHEBI:39447 CHEBI:39447
CHEBI:87071 CHEBI:87071
CHEBI:87101 CHEBI:87101
ARO:3007499 ARO:3007499

Chemical structure

Computed structure properties
Molecular formula	C16H14F3N5O
Charge	0
Average mass	349.316 Da
Monoisotopic mass	349.11504 Da
Source	ChEBI
InChIKey	BCEHBSKCWLPMDN-MGPLVRAMSA-N

SMILES

C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F

InChI

InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1

Also called

Vfend (BRAND_NAME)— chebi
voriconazol (INN)— chebi
voriconazolum (INN)— chebi
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (EXACT_SYNONYM)— chebi
(R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (EXACT_SYNONYM)— chebi
(αR,βS)-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (EXACT_SYNONYM)— chebi
VCZ (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3007512
beilstein:7694998
cas:137234-62-9
drugbank:DB00582
drugcentral:2846
kegg.compound:C07622
kegg.drug:D00578
lincs.smallmolecule:LSM-5244
patent:EP440372
patent:US5278175
wikipedia.en:Voriconazole
chembl:CHEMBL638
pubchem.compound:71616

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:35718 CHEBI:35718
CHEBI:86327 CHEBI:86327

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3007512`	voriconazole	`antibioticmech:aro-7c51b80ef5`	2026-08-30
CHEBI	`CHEBI:10023`	voriconazole	`antibioticmech:chebi-35a61b95ae`	2026-08-30

Mechanism summary

Mode of action: ERGOSTEROL_PATHWAY_INHIBITION host shared target — Assigned from ChEBI role CHEBI:75282 (ergosterol biosynthesis inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.
Clinical status: APPROVED

Resistance mechanisms

61 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 31

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Aspergillus flavus Cyp51B with mutations conferring resistance to voriconazole	ARO:3009485	not organism-specific	—	ARO:3009485 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus flavus Cyp51a with mutations conferring resistance to voriconazole	ARO:3009498	not organism-specific	—	ARO:3009498 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus flavus Cyp51c with mutations conferring resistance to voriconazole	ARO:3009283	not organism-specific	—	ARO:3009283 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus Cyp51B with mutations conferring resistance to voriconazole	ARO:3009483	not organism-specific	—	ARO:3009483 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus Cyp51a with mutations conferring resistance to voriconazole	ARO:3009503	not organism-specific	—	ARO:3009503 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus Hmg1 with mutations conferring resistance to voriconazole	ARO:3009235	not organism-specific	—	ARO:3009235 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus Hmg2 with mutations conferring resistance to voriconazole	ARO:3009369	not organism-specific	—	ARO:3009369 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus ase1 with mutations conferring resistance to voriconazole	ARO:3009274	not organism-specific	—	ARO:3009274 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus fumigatus cyp51a with mutations conferring resistance to voriconazole	ARO:3009201	not organism-specific	—	ARO:3009201 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus niger Cyp51a with mutations conferring resistance to voriconazole	ARO:3009508	not organism-specific	—	ARO:3009508 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus spp. Hmg1 with mutations conferring resistance to triazoles antibiotics	ARO:3007670	not organism-specific	—	ARO:3007670 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus spp. cyp51A with mutations conferring resistance to triazoles antibiotics	ARO:3007565	not organism-specific	—	ARO:3007565 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus terreus cyp51a with mutations conferring resistance to voriconazole	ARO:3009205	not organism-specific	—	ARO:3009205 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida albicans Cyp51 with mutations conferring resistance to voriconazole	ARO:3009526	not organism-specific	—	ARO:3009526 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida albicans Erg11 with mutations conferring resistance to voriconazole	ARO:3009415	not organism-specific	—	ARO:3009415 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida auris Erg11 lanosterol 14-alpha-demethylase with mutations associated with resistance to voriconazole	ARO:3009221	not organism-specific	—	ARO:3009221 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida auris FKS1 beta-1,3-glucan synthase with mutations conferring resistance to voriconazole	ARO:3009613	not organism-specific	—	ARO:3009613 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida orthopsilosis ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole	ARO:3009581	not organism-specific	—	ARO:3009581 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida parapsilosis Erg11 lanosterol 14-alpha-demethylase with mutations associated with resistance to voriconazole	ARO:3009582	not organism-specific	—	ARO:3009582 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida parapsilosis Erg3 C-5 sterol desaturase with mutations conferring resistance to itraconazole	ARO:3009243	not organism-specific	—	ARO:3009243 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida parapsilosis Erg3 C-5 sterol desaturase with mutations conferring resistance to voriconazole	ARO:3009245	not organism-specific	—	ARO:3009245 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida spp. ERG11 with mutations conferring resistance to azole antibiotics	ARO:3007524	not organism-specific	—	ARO:3007524 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Candida tropicalis Erg11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole	ARO:3009227	not organism-specific	—	ARO:3009227 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Colletotrichum truncatum cyp51a with mutations associated with resistance to voriconazole	ARO:3009218	not organism-specific	—	ARO:3009218 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Cryptococcus neoformans Erg11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole	ARO:3009229	not organism-specific	—	ARO:3009229 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Histoplasma capsulatum Erg11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole	ARO:3009223	not organism-specific	—	ARO:3009223 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Nakaseomyces glabratus FKS1 beta-1,3-glucan synthase with mutations associated with resistance to voriconazole	ARO:3009616	not organism-specific	—	ARO:3009616 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Nakaseomyces glabratus FKS2 beta-1,3-glucan synthase with mutations associated with resistance to voriconazole	ARO:3009620	not organism-specific	—	ARO:3009620 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Pichia kudriavzevii ERG11 with mutations conferring resistance to voriconazole	ARO:3009399	not organism-specific	—	ARO:3009399 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Saccharomyces cerevisiae ERG11 lanosterol 14-alpha-demethylase with mutations conferring resistance to voriconazole	ARO:3009591	not organism-specific	—	ARO:3009591 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
antifungal resistance-associated MSH	ARO:3009134	not organism-specific	—	ARO:3009134 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)

UNKNOWN 23

UNKNOWN
Determinant	ARO ID	Organism	Gene families	Evidence
CYP51A transformant(CM2627-CYP51Apromoter(2x34bp tandem repeat) and CM2627-CYP51A(L98H)) (transformant) [Overexpression] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain CM237 `NCBITaxon:330879` `UniProtKB:Q4WNT5` Afu4g06890-T `PHIPO:0000590`	—	PMID:17371828 (PHI-base primary-literature antimicrobial interaction PHIG:1837; joined to this record by exact ChEBI identifier.) Cell growth assay
Candida albicans TAC1 with mutations conferring resistance to voriconazole	ARO:3009429	not organism-specific	—	ARO:3009429 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
ERG11 transformant(JEY162-ERG11(824-955bpdelta + D275V) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida tropicalis `NCBITaxon:5482` strain 1909 `UniProtKB:P14263` CTRG_05283-t43_1 `PHIPO:0000590`	—	PMID:23629718 (PHI-base primary-literature antimicrobial interaction PHIG:8774; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11 transformant(MRL862-ERG11(Y145F)) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Cryptococcus neoformans `NCBITaxon:5207` strain H99 `UniProtKB:Q870D1` `PHIPO:0000590`	—	PMID:22155829 (PHI-base primary-literature antimicrobial interaction PHIG:1668; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(Y132F F145L) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000590`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG11(Y132F K143R) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:P10613` C5_00660C_A-T `PHIPO:0000590`	—	PMID:25385095 (PHI-base primary-literature antimicrobial interaction PHIG:1132; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG3 transformant(JEY162-ERG3(S258F)) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida tropicalis `NCBITaxon:5482` strain 1909 `UniProtKB:N0A5G3` `PHIPO:0000590`	—	PMID:23629718 (PHI-base primary-literature antimicrobial interaction PHIG:8773; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG3delta (deletion) associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida albicans `NCBITaxon:5476` strain SC5314 `NCBITaxon:237561` `UniProtKB:Q59VG6` C1_04770C_A-T `PHIPO:0000590`	—	PMID:28630186 (PHI-base primary-literature antimicrobial interaction PHIG:1133; joined to this record by exact ChEBI identifier.) Cell growth assay
ERG3delta (deletion) associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Candida parapsilosis `NCBITaxon:5480` strain Unknown strain `NCBITaxon:578454` `UniProtKB:G8B7T4` `PHIPO:0000590`	—	PMID:28630186 (PHI-base primary-literature antimicrobial interaction PHIG:8772; joined to this record by exact ChEBI identifier.) Cell growth assay
HapE transformant(Isolate3-HapE(P88L)) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain akuBKU80 `NCBITaxon:330879` `UniProtKB:Q4WDM9` `PHIPO:0000590`	—	PMID:23226235 (PHI-base primary-literature antimicrobial interaction PHIG:8691; joined to this record by exact ChEBI identifier.) Cell growth assay
cox10 transformant(W004-cox10(R243Q)) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain A1160C `NCBITaxon:451804` `UniProtKB:B0Y628` `PHIPO:0000590`	—	PMID:27799210 (PHI-base primary-literature antimicrobial interaction PHIG:8689; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A transformant(F33-cyp51A (G448S)) (transformant) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain F55064 `NCBITaxon:330879` `UniProtKB:Q4WNT5` Afu4g06890-T `PHIPO:0000590`	—	PMID:22897872 (PHI-base primary-literature antimicrobial interaction PHIG:1837; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A(G448S) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain H27023 `NCBITaxon:330879` `UniProtKB:Q4WNT5` Afu4g06890-T `PHIPO:0000590`	—	PMID:22897872 (PHI-base primary-literature antimicrobial interaction PHIG:1837; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A(G448S) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain W73355 `NCBITaxon:330879` `UniProtKB:Q4WNT5` Afu4g06890-T `PHIPO:0000590`	—	PMID:22897872 (PHI-base primary-literature antimicrobial interaction PHIG:1837; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A(G448S) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus fumigatus `NCBITaxon:746128` strain F55064 `NCBITaxon:330879` `UniProtKB:Q4WNT5` Afu4g06890-T `PHIPO:0000590`	—	PMID:22897872 (PHI-base primary-literature antimicrobial interaction PHIG:1837; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A(K197N) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus flavus `NCBITaxon:5059` strain X26728 `NCBITaxon:332952` `UniProtKB:B8N2C8` AFLA_001488_t1 `PHIPO:0000590`	—	PMID:18775650 (PHI-base primary-literature antimicrobial interaction PHIG:338; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A(K197N, D282E, M288L) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus flavus `NCBITaxon:5059` strain X26728 `NCBITaxon:332952` `UniProtKB:B8N2C8` AFLA_001488_t1 `PHIPO:0000590`	—	PMID:18775650 (PHI-base primary-literature antimicrobial interaction PHIG:338; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A(Y132N, T469S) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus flavus `NCBITaxon:5059` strain X26728 `NCBITaxon:332952` `UniProtKB:B8N2C8` AFLA_001488_t1 `PHIPO:0000590`	—	PMID:18775650 (PHI-base primary-literature antimicrobial interaction PHIG:338; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51A+ (wild type) [Overexpression] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus flavus `NCBITaxon:5059` strain NRRL 3357 `NCBITaxon:332952` `UniProtKB:B8N2C8` AFLA_001488_t1 `PHIPO:0000590`	—	PMID:22314539 (PHI-base primary-literature antimicrobial interaction PHIG:338; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51B(H399P, D411N) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus flavus `NCBITaxon:5059` strain X26728 `NCBITaxon:332952` `UniProtKB:B8NFL5` AFLA_005443_t1 `PHIPO:0000590`	—	PMID:18775650 (PHI-base primary-literature antimicrobial interaction PHIG:336; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51B(T454P, T486P) (amino acid mutation) [Not assayed] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus flavus `NCBITaxon:5059` strain X26728 `NCBITaxon:332952` `UniProtKB:B8NFL5` AFLA_005443_t1 `PHIPO:0000590`	—	PMID:18775650 (PHI-base primary-literature antimicrobial interaction PHIG:336; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51B+ (wild type) [Overexpression] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus flavus `NCBITaxon:5059` strain NRRL 3357 `NCBITaxon:332952` `UniProtKB:B8NFL5` AFLA_005443_t1 `PHIPO:0000590`	—	PMID:22314539 (PHI-base primary-literature antimicrobial interaction PHIG:336; joined to this record by exact ChEBI identifier.) Cell growth assay
cyp51C-T788G(S240A) (amino acid mutation) [Wild type product level] associated with resistance to voriconazole This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Aspergillus flavus `NCBITaxon:5059` strain NRRL 3357 `NCBITaxon:332952` `UniProtKB:B8NUK6` AFLA_010303_t1 `PHIPO:0000590`	—	PMID:22314539 (PHI-base primary-literature antimicrobial interaction PHIG:337; joined to this record by exact ChEBI identifier.) Cell growth assay

ANTIBIOTIC_EFFLUX 7

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
Aspergillus flavus MFS1 with mutations conferring resistance to voriconazole	ARO:3009458	not organism-specific	—	ARO:3009458 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Aspergillus flavus Mdr2 with mutations conferring resistance to voriconazole	ARO:3009451	not organism-specific	—	ARO:3009451 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mdr1 with mutations associated with resistance to voriconazole	ARO:3009252	not organism-specific	—	ARO:3009252 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mdr3 with mutations associated with resistance to voriconazole	ARO:3009257	not organism-specific	—	ARO:3009257 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mfs1 with mutations associated with resistance to voriconazole	ARO:3009265	not organism-specific	—	ARO:3009265 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
Trychophyton rubrum Mfs2 with mutations associated with resistance to voriconazole	ARO:3009267	not organism-specific	—	ARO:3009267 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)
fungal MDR	ARO:3009425	not organism-specific	—	ARO:3009425 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3007512 (voriconazole); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
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RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
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RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources
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RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources
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RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources
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Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.