AntibioticMech

4-aminosalicylic acid

CHEBI:27565 ·resolve ·ANTIMYCOBACTERIAL ·EXACT SEEDED

An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4. — ChEBI

Classification

salicylic acid antibioticARO:3007159

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:22495 CHEBI:22495
• CHEBI:33853 CHEBI:33853
• ARO:3007159 ARO:3007159

Chemical structure

Computed structure properties

Molecular formula	C7H7NO3
Charge	0
Average mass	153.137 Da
Monoisotopic mass	153.04259 Da
Source	ChEBI
InChIKey	WUBBRNOQWQTFEX-UHFFFAOYSA-N

SMILES

Nc1ccc(C(=O)O)c(O)c1

InChI

InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

Also called

• Paser (BRAND_NAME)— chebi
• 4-amino-2-hydroxybenzoic acid (EXACT_SYNONYM)— chebi
• 2-HYDROXY-4-AMINOBENZOIC ACID (EXACT_SYNONYM)— chebi
• 4-Aminosalicylate (EXACT_SYNONYM)— chebi
• 4-Aminosalicylic acid (EXACT_SYNONYM)— chebi
• Aminosalicylic acid (EXACT_SYNONYM)— chebi
• PAS (EXACT_SYNONYM)— chebi
• Para-amino salicylic acid (EXACT_SYNONYM)— chebi
• p-aminosalicylic acid (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• ARO:3004019
• cas:65-49-6
• drugbank:DB00233
• drugcentral:2050
• gmelin:306153
• hmdb:HMDB0014378
• kegg.compound:C02518
• kegg.drug:D00162
• lincs.smallmolecule:LSM-5862
• patent:DE50835
• patent:US2844625
• patent:US427564
• pdb-ccd:BHA
• reaxys:473071
• wikipedia.en:Aminosalicylic_Acid
• chembl:CHEMBL1169
• pubchem.compound:4649

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:33231 CHEBI:33231

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
ARO	ARO:3004019	para-aminosalicylic acid	antibioticmech:aro-00d24b7d96	2026-08-30
CHEBI	CHEBI:27565	4-aminosalicylic acid	antibioticmech:chebi-6e0c7e01d8	2026-08-30

Mechanism summary

Clinical status

APPROVED

Resistance mechanisms

3 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_TARGET_ALTERATION 2

ANTIBIOTIC_TARGET_ALTERATION

Determinant	ARO ID	Organism	Gene families	Evidence
Mycobacterium tuberculosis folC with mutation conferring resistance to para-aminosalicylic acid	ARO:3004157	not organism-specific	—	ARO:3004157 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004019 (para-aminosalicylic acid); database assertion, not a primary citation.)
Mycobacterium tuberculosis thyA with mutation conferring resistance to para-aminosalicylic acid	ARO:3004153	not organism-specific	—	ARO:3004153 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004019 (para-aminosalicylic acid); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_REPLACEMENT 1

ANTIBIOTIC_TARGET_REPLACEMENT

Determinant	ARO ID	Organism	Gene families	Evidence
Mycobacterium tuberculosis ribD with mutation conferring resistance to para-aminosalicylic acid	ARO:3004184	not organism-specific	—	ARO:3004184 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004019 (para-aminosalicylic acid); database assertion, not a primary citation.)

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO, CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.