4-aminosalicylic acid

CHEBI:27565 ·resolve ·ANTIMYCOBACTERIAL ·EXACT SEEDED

An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

salicylic acid antibioticARO:3007159

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:22495
Label unavailable CHEBI:33853
salicylic acid antibiotic ARO:3007159

Chemical structure

Computed structure properties
Molecular formula	C7H7NO3
Charge	0
Average mass	153.137 Da
Monoisotopic mass	153.04259 Da
Source	ChEBI
InChIKey	WUBBRNOQWQTFEX-UHFFFAOYSA-N

SMILES

Nc1ccc(C(=O)O)c(O)c1

InChI

InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

Also called

Paser (BRAND_NAME)— chebi
4-amino-2-hydroxybenzoic acid (EXACT_SYNONYM)— chebi
2-HYDROXY-4-AMINOBENZOIC ACID (EXACT_SYNONYM)— chebi
4-Aminosalicylate (EXACT_SYNONYM)— chebi
4-Aminosalicylic acid (EXACT_SYNONYM)— chebi
Aminosalicylic acid (EXACT_SYNONYM)— chebi
PAS (EXACT_SYNONYM)— chebi
Para-amino salicylic acid (EXACT_SYNONYM)— chebi
p-aminosalicylic acid (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antitubercular agent CHEBI:33231

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3004019`	para-aminosalicylic acid	`antibioticmech:aro-00d24b7d96`	2026-08-30
CHEBI	`CHEBI:27565`	4-aminosalicylic acid	`antibioticmech:chebi-6e0c7e01d8`	2026-08-30

Mechanism summary

Clinical status: APPROVED

Activity spectrum

Measured or curated activity against specific taxa. A number without a method is not an observation — every row here carries an assay.

163 observations · Browse all observations · Complete record (JSON.gz)

Observations 1–20 of 163

Activity observations
Organism	Activity	MIC	Disk diffusion	Assay	Strain	Sample/genome	Evidence
Mycobacterium tuberculosis complex	RESISTANT	—	—	CRyPTIC DST; CLIRES2020; liquid media; MGIT; MGIT960	—	269 source isolates 269 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	SUSCEPTIBLE	—	—	CRyPTIC DST; CLIRES2020; liquid media; MGIT; MGIT960	—	4112 source isolates 4112 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	RESISTANT	—	—	CRyPTIC DST; CLIRES2020; not specified	—	1 source isolates 1 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	SUSCEPTIBLE	—	—	CRyPTIC DST; CLIRES2020; not specified	—	7 source isolates 7 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	INTERMEDIATE	—	—	CRyPTIC DST; CLIRES2020; solid media	—	3 source isolates 3 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	RESISTANT	—	—	CRyPTIC DST; CLIRES2020; solid media	—	88 source isolates 88 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	SUSCEPTIBLE	—	—	CRyPTIC DST; CLIRES2020; solid media	—	1959 source isolates 1959 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	RESISTANT	—	—	CRyPTIC DST; CLIRES2023; liquid media; MGIT; MGIT960	—	33 source isolates 33 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	SUSCEPTIBLE	—	—	CRyPTIC DST; CLIRES2023; liquid media; MGIT; MGIT960	—	854 source isolates 854 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	INTERMEDIATE	—	—	CRyPTIC DST; CLIRES2023; not specified	—	1 source isolates 1 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	SUSCEPTIBLE	—	—	CRyPTIC DST; CLIRES2023; not specified	—	1 source isolates 1 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	INTERMEDIATE	—	—	CRyPTIC DST; CLIRES2023; solid media	—	2 source isolates 2 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	RESISTANT	—	—	CRyPTIC DST; CLIRES2023; solid media	—	11 source isolates 11 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	SUSCEPTIBLE	—	—	CRyPTIC DST; CLIRES2023; solid media	—	839 source isolates 839 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	—	0.25 mg/L	—	CRyPTIC DST; CRyPTIC; liquid media; microdilution plate; UKMYC5	—	539 source isolates 539 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	—	0.25 mg/L	—	CRyPTIC DST; CRyPTIC; liquid media; microdilution plate; UKMYC5	—	386 source isolates 386 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	—	0.25 mg/L	—	CRyPTIC DST; CRyPTIC; liquid media; microdilution plate; UKMYC5	—	248 source isolates 248 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	—	0.5 mg/L	—	CRyPTIC DST; CRyPTIC; liquid media; microdilution plate; UKMYC5	—	384 source isolates 384 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	—	0.5 mg/L	—	CRyPTIC DST; CRyPTIC; liquid media; microdilution plate; UKMYC5	—	390 source isolates 390 measurements	Evidence Page data (JSON.gz)
Mycobacterium tuberculosis complex	—	0.5 mg/L	—	CRyPTIC DST; CRyPTIC; liquid media; microdilution plate; UKMYC5	—	148 source isolates 148 measurements	Evidence Page data (JSON.gz)

Resistance mechanisms

3 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_TARGET_ALTERATION 2

ANTIBIOTIC_TARGET_ALTERATION
Determinant	ARO ID	Organism	Gene families	Evidence
Mycobacterium tuberculosis folC with mutation conferring resistance to para-aminosalicylic acid	ARO:3004157	not organism-specific	—	ARO:3004157 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004019 (para-aminosalicylic acid); database assertion, not a primary citation.)
Mycobacterium tuberculosis thyA with mutation conferring resistance to para-aminosalicylic acid	ARO:3004153	not organism-specific	—	ARO:3004153 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004019 (para-aminosalicylic acid); database assertion, not a primary citation.)

ANTIBIOTIC_TARGET_REPLACEMENT 1

ANTIBIOTIC_TARGET_REPLACEMENT
Determinant	ARO ID	Organism	Gene families	Evidence
Mycobacterium tuberculosis ribD with mutation conferring resistance to para-aminosalicylic acid	ARO:3004184	not organism-specific	—	ARO:3004184 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3004019 (para-aminosalicylic acid); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-26 · seed_from_sources
Re-seeded; changed: activity_spectrum (CRYPTIC 3.4.0). Upstream retrieval date 2026-08-30, unchanged.
RESEEDED_FROM_SOURCES 2026-10-05 · seed_from_sources
Re-seeded; changed: activity_membership_collections (CRYPTIC 3.4.0). Upstream retrieval date 2026-08-30, unchanged.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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