lividomycin A

CHEBI:71961 ·resolve ·ANTIMYCOBACTERIAL ·EXACT SEEDED

A member of the class of lividomycins that is lividomycin B in which position 4 of the diamino-L-idopyranosyl moiety has been converted into its α-D-mannopyranoside. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

aminoglycoside antibioticARO:0000016

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:71960 CHEBI:71960
ARO:0000016 ARO:0000016

Chemical structure

Computed structure properties
Molecular formula	C29H55N5O18
Charge	0
Average mass	761.776 Da
Monoisotopic mass	761.35421 Da
Source	ChEBI
InChIKey	DBLVDAUGBTYDFR-SWMBIRFSSA-N

SMILES

NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)C[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O

InChI

InChI=1S/C29H55N5O18/c30-3-11-23(51-28-20(43)19(42)17(40)13(5-36)47-28)18(41)15(34)27(45-11)50-24-14(6-37)48-29(21(24)44)52-25-16(39)7(31)1-8(32)22(25)49-26-9(33)2-10(38)12(4-35)46-26/h7-29,35-44H,1-6,30-34H2/t7-,8+,9-,10+,11+,12-,13-,14-,15-,16+,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+/m1/s1

Also called

lividomicina (INN)— chebi
lividomycin (INN)— chebi
lividomycine (INN)— chebi
lividomycinum (INN)— chebi
(1R,2R,3S,4R,6S)-4,6-diamino-3-hydroxy-2-{[α-D-mannopyranosyl-(1→4)-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl]oxy}cyclohexyl 2-amino-2,3-dideoxy-α-D-ribo-hexopyranoside (EXACT_SYNONYM)— chebi
O-2-amino-2,3-dideoxy-α-D-ribo-hexopyranosyl-(1-4)-O-(O-α-D-mannopyranosyl-(1-4)-O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1-3)-β-D-ribofuranosyl-(1-5))-2-deoxy-D-streptamine (EXACT_SYNONYM)— chebi
SF 767 A (EXACT_SYNONYM)— chebi
antibiotic 503-2 (EXACT_SYNONYM)— chebi
antibiotic SF 767 A (EXACT_SYNONYM)— chebi
mannosyldeoxyparomomycin (EXACT_SYNONYM)— chebi
quintomycin B (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

ARO:3000658
ARO:3000700
cas:36441-41-5
drugbank:DB04728
kegg.compound:C17707
metacyc.compound:CPD-14175
pdb-ccd:LIV
reaxys:6763509
wikipedia.en:Lividomycin
chembl:CHEMBL389029
pubchem.compound:72394

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33231 CHEBI:33231
CHEBI:33281 CHEBI:33281
CHEBI:33282 CHEBI:33282

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:3000658`	lividomycin	`antibioticmech:aro-105b40883a`	2026-08-30
ARO	`ARO:3000700`	lividomycin A	`antibioticmech:aro-d6153d329b`	2026-08-30
CHEBI	`CHEBI:71961`	lividomycin A	`antibioticmech:chebi-5c7729a83c`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000755

CARD/ARO database assertion; target organism, strain, and assay are not specified. 16S rRNA is asserted as the target. Evidence status: PRIMARY_EVIDENCE_NEEDED. Source: CARD_ARO 2026-08-30 (retrieved 2026-08-30).

ARO:3000755 (CARD/ARO asserts targeted_by_antibiotic ARO:3000658 (lividomycin); database assertion, not a primary citation.)

antibiotic sensitive 16S rRNA NUCLEIC_ACID DIRECT_BINDING_TARGET

ARO:3000755

ARO:3000755 (CARD/ARO asserts targeted_by_antibiotic ARO:3000700 (lividomycin A); database assertion, not a primary citation.)

Resistance mechanisms

5 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_INACTIVATION 5

ANTIBIOTIC_INACTIVATION
Determinant	ARO ID	Organism	Gene families	Evidence
AAC(3)-IIIa	ARO:3002536	not organism-specific	—	ARO:3002536 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000658 (lividomycin); database assertion, not a primary citation.)
AAC(3)-IIIb	ARO:3002537	not organism-specific	—	ARO:3002537 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000658 (lividomycin); database assertion, not a primary citation.)
APH(3')-IIIa	ARO:3002647	not organism-specific	—	ARO:3002647 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000658 (lividomycin); database assertion, not a primary citation.)
APH(3')-Ia	ARO:3002641	not organism-specific	—	ARO:3002641 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000658 (lividomycin); database assertion, not a primary citation.)
APH(3')-Ib	ARO:3002642	not organism-specific	—	ARO:3002642 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3000658 (lividomycin); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO, CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.