2,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone

CHEBI:66265 ·resolve ·ANTIPROTOZOAL ·EXACT SEEDED

A member of the class of chalcones that is 3',5'-dimethylchalcone substituted by hydroxy groups at positions 2, 2' and 4' and a methoxy group at position 6'. Isolated from Psorothamnus polydenius, it exhibits antiparasitic activity. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:23086 CHEBI:23086
CHEBI:25235 CHEBI:25235
CHEBI:26195 CHEBI:26195

Chemical structure

Computed structure properties
Molecular formula	C18H18O5
Charge	0
Average mass	314.337 Da
Monoisotopic mass	314.11542 Da
Source	ChEBI
InChIKey	SPWBEELZNSXNME-CMDGGOBGSA-N

SMILES

COc1c(C)c(O)c(C)c(O)c1C(=O)/C=C/c1ccccc1O

InChI

InChI=1S/C18H18O5/c1-10-16(21)11(2)18(23-3)15(17(10)22)14(20)9-8-12-6-4-5-7-13(12)19/h4-9,19,21-22H,1-3H3/b9-8+

Also called

(2E)-1-(2,4-dihydroxy-6-methoxy-3,5-dimethylphenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

reaxys:10194818

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:36335 CHEBI:36335
CHEBI:70868 CHEBI:70868

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:66265`	2,2',4'-trihydroxy-6'-methoxy-3',5'-dimethylchalcone	`antibioticmech:chebi-2600a3293e`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.