artemether

CHEBI:195280 ·resolve ·ANTIPROTOZOAL ·EXACT SEEDED

An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:25702 CHEBI:25702
CHEBI:26658 CHEBI:26658
CHEBI:59770 CHEBI:59770
CHEBI:63920 CHEBI:63920
CHEBI:72588 CHEBI:72588

Chemical structure

Computed structure properties
Molecular formula	C16H26O5
Charge	0
Average mass	298.379 Da
Monoisotopic mass	298.17802 Da
Source	ChEBI
InChIKey	SXYIRMFQILZOAM-HVNFFKDJSA-N

SMILES

[H][C@]12O[C@H](OC)[C@H](C)[C@]3([H])CC[C@@H](C)[C@]4([H])CC[C@@](C)(OO[C@]143)O2

InChI

InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1

Also called

artemetero (INN)— chebi
artemetherum (INN)— chebi
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine (EXACT_SYNONYM)— chebi
(1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane (EXACT_SYNONYM)— chebi
10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane (EXACT_SYNONYM)— chebi
artemisininelactol methyl ether (EXACT_SYNONYM)— chebi
dihydroartemisinin methyl ether (EXACT_SYNONYM)— chebi
methyl-dihydroartemisinine (EXACT_SYNONYM)— chebi
β-artemether (EXACT_SYNONYM)— chebi
β-dihydroartemisinin methyl ether (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

beilstein:6569878
cas:71963-77-4
drugbank:DB06697
drugcentral:245
kegg.drug:D02483
lincs.smallmolecule:LSM-5519
wikipedia.en:Artemether

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:38068 CHEBI:38068

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:195280`	artemether	`antibioticmech:chebi-4ee5919c05`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.