benznidazole

CHEBI:133833 ·resolve ·ANTIPROTOZOAL ·EXACT SEEDED

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:24780 CHEBI:24780
CHEBI:29347 CHEBI:29347
CHEBI:35716 CHEBI:35716

Chemical structure

Computed structure properties
Molecular formula	C12H12N4O3
Charge	0
Average mass	260.253 Da
Monoisotopic mass	260.09094 Da
Source	ChEBI
InChIKey	CULUWZNBISUWAS-UHFFFAOYSA-N

SMILES

O=C(Cn1ccnc1[N+](=O)[O-])NCc1ccccc1

InChI

InChI=1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)

Also called

benznidazol (INN)— chebi
benznidazolum (INN)— chebi
N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide (EXACT_SYNONYM)— chebi
2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide (EXACT_SYNONYM)— chebi
N-Benzyl-2-nitroimidazol-1-yl-acetamide (EXACT_SYNONYM)— chebi
N-Benzyl-2-nitroimidazole-1-acetamide (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:22994-85-0
drugcentral:322
kegg.drug:D02489
reaxys:551486
wikipedia.en:Benznidazole

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:35820 CHEBI:35820

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:133833`	benznidazole	`antibioticmech:chebi-63888122bb`	2026-08-30

Mechanism summary

Clinical status: APPROVED

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.