dehydroemetine

CHEBI:149634 ·resolve ·ANTIPROTOZOAL ·EXACT SEEDED

A pyridoisoquinoline which was developed in response to the cardiovascular toxicity associated with emetine and results from the dehydrogenation of the heterotricylic ring of emetine. It is an antiprotozoal agent and displays antimalarial, antiamoebic, and antileishmanial properties. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:24922 CHEBI:24922
CHEBI:35618 CHEBI:35618
CHEBI:61692 CHEBI:61692

Chemical structure

Computed structure properties
Charge
Source	ChEBI
InChIKey	XXLZPUYGHQWHRN-RPBOFIJWSA-N

SMILES

[H][C@@]12CC(C[C@H]3NCCc4cc(OC)c(OC)cc43)=C(CC)CN1CCc1cc(OC)c(OC)cc12

InChI

InChI=1S/C29H38N2O4/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24/h13-16,24-25,30H,6-12,17H2,1-5H3/t24-,25+/m1/s1

Also called

Dametin (BRAND_NAME)— chebi
Mebadin (BRAND_NAME)— chebi
Mebadine (BRAND_NAME)— chebi
dehidroemetina (INN)— chebi
dehydroemetinum (INN)— chebi
déhydroémétine (INN)— chebi
6',7',10,11-tetramethoxy-2,3-didehydroemetan (EXACT_SYNONYM)— chebi
(−)-2,3-dehydroemetine (EXACT_SYNONYM)— chebi
(−)-R,S-dehydroemetine (EXACT_SYNONYM)— chebi
2,3-didehydro-6',7',10,11-tetramethoxyemetan (EXACT_SYNONYM)— chebi
2,3-didehydroemetine (EXACT_SYNONYM)— chebi
2-dehydroemetine (EXACT_SYNONYM)— chebi
BT 436 (EXACT_SYNONYM)— chebi
Ro 1-9334 (EXACT_SYNONYM)— chebi
Ro 1-9334/19 (EXACT_SYNONYM)— chebi
Ro-1-9334/19 (EXACT_SYNONYM)— chebi
Ro-1933419 (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:4914-30-1
drugbank:DB13865
drugcentral:3129
kegg.compound:C07996
kegg.drug:D00828
wikipedia.en:Dehydroemetine

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:35820 CHEBI:35820
CHEBI:38068 CHEBI:38068
CHEBI:70868 CHEBI:70868

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:149634`	dehydroemetine	`antibioticmech:chebi-18a3a93b5d`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.