eflornithine

CHEBI:41948 ·resolve ·ANTIPROTOZOAL ·EXACT SEEDED

A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:24068 CHEBI:24068
CHEBI:33704 CHEBI:33704

Chemical structure

Computed structure properties
Molecular formula	C6H12F2N2O2
Charge	0
Average mass	182.17 Da
Monoisotopic mass	182.08668 Da
Source	ChEBI
InChIKey	VLCYCQAOQCDTCN-UHFFFAOYSA-N

SMILES

NCCCC(N)(C(=O)O)C(F)F

InChI

InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)

Also called

2,5-diamino-2-(difluoromethyl)pentanoic acid (EXACT_SYNONYM)— chebi
2-(difluoromethyl)ornithine (EXACT_SYNONYM)— chebi
ALPHA-DIFLUOROMETHYLORNITHINE (EXACT_SYNONYM)— chebi
DFMO (EXACT_SYNONYM)— chebi
DL-Ornithine, 2-(difluoromethyl)- (EXACT_SYNONYM)— chebi
Eflornithine (EXACT_SYNONYM)— chebi
alpha-(Difluoromethyl)-DL-ornithine (EXACT_SYNONYM)— chebi
α-difluoromethylornithine (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

beilstein:2250529
cas:67037-37-0
cas:70052-12-9
drugbank:DB03856
drugcentral:990
kegg.compound:C07997
kegg.drug:D07883
pdb-ccd:DMO
reaxys:2250529
wikipedia.en:Eflornithine

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:36335 CHEBI:36335

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:41948`	eflornithine	`antibioticmech:chebi-15dccd4582`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.