hookerianamide H

CHEBI:66020 ·resolve ·ANTIPROTOZOAL ·EXACT SEEDED

A steroid alkaloid that is 5α-pregn-2-ene-4-one substituted by a N-formylamino group at position 3 and a N,N-dimethylamino group at position 20. Isolated from Sarcococca hookeriana, it exhibits antiplasmodial activity and inhibitory activity against cholinesterase. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:24079 CHEBI:24079
CHEBI:26767 CHEBI:26767
CHEBI:51689 CHEBI:51689

Chemical structure

Computed structure properties
Molecular formula	C24H38N2O2
Charge	0
Average mass	386.58 Da
Monoisotopic mass	386.29333 Da
Source	ChEBI
InChIKey	BRKREXSOPCTPTI-BLXLMBLLSA-N

SMILES

[H][C@@]12CC[C@@]3([H])C(=O)C(NC=O)=CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1([H])[C@H](C)N(C)C

InChI

InChI=1S/C24H38N2O2/c1-15(26(4)5)17-8-9-18-16-6-7-20-22(28)21(25-14-27)11-13-24(20,3)19(16)10-12-23(17,18)2/h11,14-20H,6-10,12-13H2,1-5H3,(H,25,27)/t15-,16-,17+,18-,19-,20-,23+,24+/m0/s1

Also called

N-[(5α,20S)-20-(dimethylamino)-4-oxopregn-2-en-3-yl]formamide (EXACT_SYNONYM)— chebi
20(N,N-dimethylamino)-3-(N-formylamino)-5α-pregn-2-ene-4-one (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

reaxys:18885920

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:64915 CHEBI:64915

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:66020`	hookerianamide H	`antibioticmech:chebi-eea0e87d94`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.